Association of cerebrospinal fluid ferritin levelwith preclinical cognitive decline in APOE-ϵ4 carriers

JAMA Neurology

Volumn 74, Issue 1, 2017, Pages 122-125

  Ayton, Scott ^a   Faux, Noel G ^a,b   Bush, Ashley I ^a,b,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b IBM RESEARCH   (United States)

^c Academic Centre for Community Mental Health   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; COMPLEMENT FACTOR H; FERRITIN; HEMOGLOBIN; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT;

AGED; ALZHEIMER DISEASE ASSESSMENT SCALE; APOE E4 GENE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HETEROZYGOTE; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; MILD COGNITIVE IMPAIRMENT; PREDICTION; PROTEIN CEREBROSPINAL FLUID LEVEL; REY AUDITORY VERBAL LEARNING TEST; CEREBROSPINAL FLUID; GENETICS; NEUROPSYCHOLOGICAL TEST; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AMYLOID BETA-PEPTIDES; APOLIPOPROTEIN E4; COGNITIVE DYSFUNCTION; FEMALE; FERRITINS; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PEPTIDE FRAGMENTS;

EID: 85011395623     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2016.4406     Document Type: Letter

References (6)

1. Ayton S, Faux NG, Bush AI; Alzheimer's Disease Neuroimaging Initiative. Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nat Commun. 2015;6:6760.
2. Alzheimer Disease Neuroimaging Initiative (ADNI) database http://adni.loni.usc .edu. Accessed July 15, 2014.
3. WeinerMW, Veitch DP, Aisen PS, et al; Alzheimer's Disease Neuroimaging Initiative. The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement. 2012;8(1)(suppl):S1-S68.
4. Estévez-González A, Kulisevsky J, Boltes A, Otermín P, García-Sánchez C. Rey verbal learning test is a useful tool for differential diagnosis in the preclinical phase of Alzheimer's disease: comparison with mild cognitive impairment and normal aging. Int J Geriatr Psychiatry. 2003;18(11):1021-1028.
5. Iturria-Medina Y, Sotero RC, Toussaint PJ, Mateos-Pérez JM, Evans AC; Alzheimer's Disease Neuroimaging Initiative. Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nat Commun. 2016;7:11934.
6. Ali-Rahmani F, Schengrund CL, Connor JR. HFE gene variants, iron, and lipids: a novel connection in Alzheimer's disease. Front Pharmacol. 2014;5:165.