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Volumn 61, Issue 2, 2017, Pages

Polymyxin B in combination with rifampin and meropenem against polymyxin B-resistant KPC-producing Klebsiella pneumoniae

Author keywords

Carbapenemase; Klebsiella pneumoniae; Pharmacodynamics; Polymyxin B; Triple combination

Indexed keywords

BACTERIAL ENZYME; CARBAPENEMASE; MEROPENEM; POLYMYXIN B; RIFAMPICIN; ANTIINFECTIVE AGENT; BETA LACTAMASE; THIENAMYCIN DERIVATIVE;

EID: 85011066639     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02121-16     Document Type: Article
Times cited : (29)

References (54)
  • 1
    • 34547422759 scopus 로고    scopus 로고
    • Carbapenemases: The versatile betalactamases
    • Queenan AM, Bush K. 2007. Carbapenemases: the versatile betalactamases. Clin Microbiol Rev 20:440-458. https://doi.org/10.1128/ CMR.00001-07.
    • (2007) Clin Microbiol Rev , vol.20 , pp. 440-458
    • Queenan, A.M.1    Bush, K.2
  • 2
    • 77957770819 scopus 로고    scopus 로고
    • Alarming beta-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae
    • Bush K. 2010. Alarming beta-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae. Curr Opin Microbiol 13: 558-564. https://doi.org/10.1016/j.mib.2010.09.006.
    • (2010) Curr Opin Microbiol , vol.13 , pp. 558-564
    • Bush, K.1
  • 3
    • 84930486688 scopus 로고    scopus 로고
    • Global spread of carbapenemaseproducing Enterobacteriaceae
    • Nordmann P, Naas T, Poirel L. 2011. Global spread of carbapenemaseproducing Enterobacteriaceae. Emerg Infect Dis 17:1791-1798. https:// doi.org/10.3201/eid1710.110655.
    • (2011) Emerg Infect Dis , vol.17 , pp. 1791-1798
    • Nordmann, P.1    Naas, T.2    Poirel, L.3
  • 4
    • 78349311509 scopus 로고    scopus 로고
    • Multiresistant Gram-negative infections: A global perspective
    • Ho J, Tambyah PA, Paterson DL. 2010. Multiresistant Gram-negative infections: a global perspective. Curr Opin Infect Dis 23:546-553. https:// doi.org/10.1097/QCO.0b013e32833f0d3e.
    • (2010) Curr Opin Infect Dis , vol.23 , pp. 546-553
    • Ho, J.1    Tambyah, P.A.2    Paterson, D.L.3
  • 5
    • 85011064618 scopus 로고    scopus 로고
    • Anonymous Centers for Disease Control and Prevention, Atlanta, GA Accessed 2 October 2015
    • Anonymous. 2013. Antibiotic/antimicrobial resistance: biggest threats. Centers for Disease Control and Prevention, Atlanta, GA. http:// www.cdc.gov/drugresistance/biggest-threats.html. Accessed 2 October 2015.
    • (2013) Antibiotic/antimicrobial Resistance: Biggest Threats
  • 9
    • 17644389620 scopus 로고    scopus 로고
    • Colistin: The revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections
    • Falagas ME, Kasiakou SK. 2005. Colistin: the revival of polymyxins for the management of multidrug-resistant Gram-negative bacterial infections. Clin Infect Dis 40:1333-1341. https://doi.org/10.1086/429323.
    • (2005) Clin Infect Dis , vol.40 , pp. 1333-1341
    • Falagas, M.E.1    Kasiakou, S.K.2
  • 10
    • 70349135927 scopus 로고    scopus 로고
    • Multidrug-resistant Gram-negative infections: What are the treatment options?
    • Giamarellou H, Poulakou G. 2009. Multidrug-resistant Gram-negative infections: what are the treatment options? Drugs 69:1879-1901. https://doi.org/10.2165/11315690-000000000-00000.
    • (2009) Drugs , vol.69 , pp. 1879-1901
    • Giamarellou, H.1    Poulakou, G.2
  • 11
    • 84905394181 scopus 로고    scopus 로고
    • In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment
    • Cannatelli A, Di Pilato V, Giani T, Arena F, Ambretti S, Gaibani P, D'Andrea MM, Rossolini GM. 2014. In vivo evolution to colistin resistance by PmrB sensor kinase mutation in KPC-producing Klebsiella pneumoniae is associated with low-dosage colistin treatment. Antimicrob Agents Chemother 58:4399-4403. https://doi.org/10.1128/AAC.02555-14.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 4399-4403
    • Cannatelli, A.1    Di Pilato, V.2    Giani, T.3    Arena, F.4    Ambretti, S.5    Gaibani, P.6    D'Andrea, M.M.7    Rossolini, G.M.8
  • 12
    • 79952807673 scopus 로고    scopus 로고
    • Colistin heteroresistance in carbapenemase-producing Klebsiella pneumoniae
    • Meletis G, Tzampaz E, Sianou E, Tzavaras I, Sofianou D. 2011. Colistin heteroresistance in carbapenemase-producing Klebsiella pneumoniae. J Antimicrob Chemother 66:946-947. https://doi.org/10.1093/jac/dkr007.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 946-947
    • Meletis, G.1    Tzampaz, E.2    Sianou, E.3    Tzavaras, I.4    Sofianou, D.5
  • 13
    • 77955516386 scopus 로고    scopus 로고
    • Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin
    • Kontopoulou K, Protonotariou E, Vasilakos K, Kriti M, Koteli A, Antoniadou E, Sofianou D. 2010. Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin. J Hosp Infect 76:70-73. https://doi.org/10.1016/j.jhin.2010.03.021.
    • (2010) J Hosp Infect , vol.76 , pp. 70-73
    • Kontopoulou, K.1    Protonotariou, E.2    Vasilakos, K.3    Kriti, M.4    Koteli, A.5    Antoniadou, E.6    Sofianou, D.7
  • 15
    • 84908528845 scopus 로고    scopus 로고
    • Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: A rapidly evolving problem in Italy, November 2013 to April 2014
    • pii-20939
    • Monaco M, Giani T, Raffone M, Arena F, Garcia-Fernandez A, Pollini S, Grundmann H, Pantosti A, Rossolini GM. 2014. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill 19(42):pii-20939. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId-20939.
    • (2014) Euro Surveill , vol.19 , Issue.42
    • Monaco, M.1    Giani, T.2    Raffone, M.3    Arena, F.4    Garcia-Fernandez, A.5    Pollini, S.6    Grundmann, H.7    Pantosti, A.8    Rossolini, G.M.9
  • 19
    • 77952928943 scopus 로고    scopus 로고
    • Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: A matched case-control study
    • Zarkotou O, Pournaras S, Voulgari E, Chrysos G, Prekates A, Voutsinas D, Themeli-Digalaki K, Tsakris A. 2010. Risk factors and outcomes associated with acquisition of colistin-resistant KPC-producing Klebsiella pneumoniae: a matched case-control study. J Clin Microbiol 48: 2271-2274. https://doi.org/10.1128/JCM.02301-09.
    • (2010) J Clin Microbiol , vol.48 , pp. 2271-2274
    • Zarkotou, O.1    Pournaras, S.2    Voulgari, E.3    Chrysos, G.4    Prekates, A.5    Voutsinas, D.6    Themeli-Digalaki, K.7    Tsakris, A.8
  • 21
    • 79960345860 scopus 로고    scopus 로고
    • Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae
    • Pankey GA, Ashcraft DS. 2011. Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae. Diagn Microbiol Infect Dis 70:561-564. https://doi.org/10.1016/j.diagmicrobio.2011.05.003.
    • (2011) Diagn Microbiol Infect Dis , vol.70 , pp. 561-564
    • Pankey, G.A.1    Ashcraft, D.S.2
  • 22
    • 84902455414 scopus 로고    scopus 로고
    • In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPCproducing Klebsiella pneumoniae bloodstream isolates
    • Gaibani P, Lombardo D, Lewis RE, Mercuri M, Bonora S, Landini MP, Ambretti S. 2014. In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPCproducing Klebsiella pneumoniae bloodstream isolates. J Antimicrob Chemother 69:1856-1865. https://doi.org/10.1093/jac/dku065.
    • (2014) J Antimicrob Chemother , vol.69 , pp. 1856-1865
    • Gaibani, P.1    Lombardo, D.2    Lewis, R.E.3    Mercuri, M.4    Bonora, S.5    Landini, M.P.6    Ambretti, S.7
  • 23
    • 77957795090 scopus 로고    scopus 로고
    • In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae
    • Elemam A, Rahimian J, Doymaz M. 2010. In vitro evaluation of antibiotic synergy for polymyxin B-resistant carbapenemase-producing Klebsiella pneumoniae. J Clin Microbiol 48:3558-3562. https://doi.org/10.1128/ JCM.01106-10.
    • (2010) J Clin Microbiol , vol.48 , pp. 3558-3562
    • Elemam, A.1    Rahimian, J.2    Doymaz, M.3
  • 24
    • 24044518439 scopus 로고    scopus 로고
    • Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: Molecular epidemiology and in vitro activity of polymyxin B and other agents
    • Bratu S, Tolaney P, Karumudi U, Quale J, Mooty M, Nichani S, Landman D. 2005. Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents. J Antimicrob Chemother 56:128-132. https://doi.org/ 10.1093/jac/dki175.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 128-132
    • Bratu, S.1    Tolaney, P.2    Karumudi, U.3    Quale, J.4    Mooty, M.5    Nichani, S.6    Landman, D.7
  • 25
    • 84878278251 scopus 로고    scopus 로고
    • 10 '20 progress - Development of new drugs active against Gram-negative bacilli: An update from the Infectious Diseases Society of America
    • Infectious Diseases Society of America
    • Boucher HW, Talbot GH, Benjamin DK, Jr, Bradley J, Guidos RJ, Jones RN, Murray BE, Bonomo RA, Gilbert D, Infectious Diseases Society of America. 2013. 10 '20 progress - development of new drugs active against Gram-negative bacilli: an update from the Infectious Diseases Society of America. Clin Infect Dis 56:1685-1694. https://doi.org/10.1093/cid/ cit152.
    • (2013) Clin Infect Dis , vol.56 , pp. 1685-1694
    • Boucher, H.W.1    Talbot, G.H.2    Benjamin, D.K.3    Bradley, J.4    Guidos, R.J.5    Jones, R.N.6    Murray, B.E.7    Bonomo, R.A.8    Gilbert, D.9
  • 27
    • 81255171675 scopus 로고    scopus 로고
    • Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment
    • Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K, Prekates A, Themeli-Digalaki K, Tsakris A. 2011. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 17:1798-1803. https://doi.org/10.1111/j.1469-0691.2011.03514.x.
    • (2011) Clin Microbiol Infect , vol.17 , pp. 1798-1803
    • Zarkotou, O.1    Pournaras, S.2    Tselioti, P.3    Dragoumanos, V.4    Pitiriga, V.5    Ranellou, K.6    Prekates, A.7    Themeli-Digalaki, K.8    Tsakris, A.9
  • 28
    • 84929629956 scopus 로고    scopus 로고
    • In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials
    • Barth N, Ribeiro VB, Zavascki AP. 2015. In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials. Antimicrob Agents Chemother 59:3596-3597. https://doi.org/ 10.1128/AAC.00365-15.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 3596-3597
    • Barth, N.1    Ribeiro, V.B.2    Zavascki, A.P.3
  • 29
    • 84931282008 scopus 로고    scopus 로고
    • Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay
    • Toledo PV, Aranha AA, Jr, Arend LN, Ribeiro V, Zavascki AP, Tuon FF. 2015. Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay. Antimicrob Agents Chemother 59:4301-4304. https://doi.org/ 10.1128/AAC.00323-15.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 4301-4304
    • Toledo, P.V.1    Aranha, A.A.2    Arend, L.N.3    Ribeiro, V.4    Zavascki, A.P.5    Tuon, F.F.6
  • 31
    • 84896836951 scopus 로고    scopus 로고
    • Evaluation of double-and triple-antibiotic combinations for VIM-and NDM-producing Klebsiella pneumoniae by in vitro time-kill experiments
    • Tangden T, Hickman RA, Forsberg P, Lagerback P, Giske CG, Cars O. 2014. Evaluation of double-and triple-antibiotic combinations for VIM-and NDM-producing Klebsiella pneumoniae by in vitro time-kill experiments. Antimicrob Agents Chemother 58:1757-1762. https://doi.org/10.1128/ AAC.00741-13.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 1757-1762
    • Tangden, T.1    Hickman, R.A.2    Forsberg, P.3    Lagerback, P.4    Giske, C.G.5    Cars, O.6
  • 32
    • 77952607889 scopus 로고    scopus 로고
    • In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrugresistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli
    • Urban C, Mariano N, Rahal JJ. 2010. In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrugresistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Antimicrob Agents Chemother 54: 2732-2734. https://doi.org/10.1128/AAC.01768-09.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2732-2734
    • Urban, C.1    Mariano, N.2    Rahal, J.J.3
  • 34
    • 77949346087 scopus 로고    scopus 로고
    • Structure-activity relationships of polymyxin antibiotics
    • Velkov T, Thompson PE, Nation RL, Li J. 2010. Structure-activity relationships of polymyxin antibiotics. J Med Chem 53:1898-1916. https:// doi.org/10.1021/jm900999h.
    • (2010) J Med Chem , vol.53 , pp. 1898-1916
    • Velkov, T.1    Thompson, P.E.2    Nation, R.L.3    Li, J.4
  • 35
    • 84896860491 scopus 로고    scopus 로고
    • New dosing strategies for an old antibiotic: Pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease
    • Rao GG, Ly NS, Haas CE, Garonzik S, Forrest A, Bulitta JB, Kelchlin PA, Holden PN, Nation RL, Li J, Tsuji BT. 2014. New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease. Antimicrob Agents Chemother 58:1381-1388. https://doi.org/10.1128/ AAC.00327-13.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 1381-1388
    • Rao, G.G.1    Ly, N.S.2    Haas, C.E.3    Garonzik, S.4    Forrest, A.5    Bulitta, J.B.6    Kelchlin, P.A.7    Holden, P.N.8    Nation, R.L.9    Li, J.10    Tsuji, B.T.11
  • 36
    • 80054088449 scopus 로고    scopus 로고
    • Incidence of and risk factors for colistin-associated nephrotoxicity in a large academic health system
    • Pogue JM, Lee J, Marchaim D, Yee V, Zhao JJ, Chopra T, Lephart P, Kaye KS. 2011. Incidence of and risk factors for colistin-associated nephrotoxicity in a large academic health system. Clin Infect Dis 53:879-884. https://doi.org/10.1093/cid/cir611.
    • (2011) Clin Infect Dis , vol.53 , pp. 879-884
    • Pogue, J.M.1    Lee, J.2    Marchaim, D.3    Yee, V.4    Zhao, J.J.5    Chopra, T.6    Lephart, P.7    Kaye, K.S.8
  • 37
    • 84897982911 scopus 로고    scopus 로고
    • Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium
    • Tuon FF, Rigatto MH, Lopes CK, Kamei LK, Rocha JL, Zavascki AP. 2014. Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium. Int J Antimicrob Agents 43: 349-352. https://doi.org/10.1016/j.ijantimicag.2013.12.002.
    • (2014) Int J Antimicrob Agents , vol.43 , pp. 349-352
    • Tuon, F.F.1    Rigatto, M.H.2    Lopes, C.K.3    Kamei, L.K.4    Rocha, J.L.5    Zavascki, A.P.6
  • 42
    • 34447289616 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of a higher rifampin dose versus the standard dose in pulmonary tuberculosis patients
    • Ruslami R, Nijland HM, Alisjahbana B, Parwati I, van Crevel R, Aarnoutse RE. 2007. Pharmacokinetics and tolerability of a higher rifampin dose versus the standard dose in pulmonary tuberculosis patients. Antimicrob Agents Chemother 51:2546-2551. https://doi.org/ 10.1128/AAC.01550-06.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2546-2551
    • Ruslami, R.1    Nijland, H.M.2    Alisjahbana, B.3    Parwati, I.4    Van Crevel, R.5    Aarnoutse, R.E.6
  • 43
    • 0022347031 scopus 로고
    • Pharmacokinetics of oral and intravenous rifampicin during chronic administration
    • Loos U, Musch E, Jensen JC, Mikus G, Schwabe HK, Eichelbaum M. 1985. Pharmacokinetics of oral and intravenous rifampicin during chronic administration. Klin Wochenschr 63:1205-1211. https://doi.org/10.1007/ BF01733779.
    • (1985) Klin Wochenschr , vol.63 , pp. 1205-1211
    • Loos, U.1    Musch, E.2    Jensen, J.C.3    Mikus, G.4    Schwabe, H.K.5    Eichelbaum, M.6
  • 44
    • 16244372376 scopus 로고    scopus 로고
    • Comparison of the pharmacodynamics of meropenem in patients with ventilatorassociated pneumonia following administration by 3-hour infusion or bolus injection
    • Jaruratanasirikul S, Sriwiriyajan S, Punyo J. 2005. Comparison of the pharmacodynamics of meropenem in patients with ventilatorassociated pneumonia following administration by 3-hour infusion or bolus injection. Antimicrob Agents Chemother 49:1337-1339. https:// doi.org/10.1128/AAC.49.4.1337-1339.2005.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1337-1339
    • Jaruratanasirikul, S.1    Sriwiriyajan, S.2    Punyo, J.3
  • 45
    • 27744482727 scopus 로고    scopus 로고
    • Intrapulmonary pharmacokinetics and pharmacodynamics of meropenem
    • Conte JE, Jr, Golden JA, Kelley MG, Zurlinden E. 2005. Intrapulmonary pharmacokinetics and pharmacodynamics of meropenem. Int J Antimicrob Agents 26:449-456. https://doi.org/10.1016/j.ijantimicag.2005.08.015.
    • (2005) Int J Antimicrob Agents , vol.26 , pp. 449-456
    • Conte, J.E.1    Golden, J.A.2    Kelley, M.G.3    Zurlinden, E.4
  • 46
    • 85011056002 scopus 로고    scopus 로고
    • AstraZeneca AstraZeneca Pharmaceuticals LP, Wilmington, DE
    • AstraZeneca. 2013. MerremIV package insert. AstraZeneca Pharmaceuticals LP, Wilmington, DE.
    • (2013) MerremIV Package Insert
  • 47
    • 0027468311 scopus 로고
    • Pharmacokinetics of meropenem in patients with various degrees of renal function, including patients with end-stage renal disease
    • Chimata M, Nagase M, Suzuki Y, Shimomura M, Kakuta S. 1993. Pharmacokinetics of meropenem in patients with various degrees of renal function, including patients with end-stage renal disease. Antimicrob Agents Chemother 37:229-233. https://doi.org/10.1128/AAC.37.2.229.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 229-233
    • Chimata, M.1    Nagase, M.2    Suzuki, Y.3    Shimomura, M.4    Kakuta, S.5
  • 48
    • 84880260396 scopus 로고    scopus 로고
    • Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/pharmacodynamic model
    • Lee HJ, Bergen PJ, Bulitta JB, Tsuji B, Forrest A, Nation RL, Li J. 2013. Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/pharmacodynamic model. Antimicrob Agents Chemother 57:3738-3745. https://doi.org/10.1128/AAC.00703-13.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 3738-3745
    • Lee, H.J.1    Bergen, P.J.2    Bulitta, J.B.3    Tsuji, B.4    Forrest, A.5    Nation, R.L.6    Li, J.7
  • 49
    • 84894087843 scopus 로고    scopus 로고
    • Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media
    • Cheah SE, Bulitta JB, Li J, Nation RL. 2014. Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media. J Pharm Biomed Anal 92:177-182. https:// doi.org/10.1016/j.jpba.2014.01.015.
    • (2014) J Pharm Biomed Anal , vol.92 , pp. 177-182
    • Cheah, S.E.1    Bulitta, J.B.2    Li, J.3    Nation, R.L.4
  • 50
    • 84870757623 scopus 로고    scopus 로고
    • Development and validation of high performance liquid chromatographic method for the determination of rifampicin in human plasma
    • Siddhartha TS, Prasanthi B, Santosh T, Ratna JV. 2012. Development and validation of high performance liquid chromatographic method for the determination of rifampicin in human plasma. Int J Pharm Pharm Sci 4:362-367.
    • (2012) Int J Pharm Pharm Sci , vol.4 , pp. 362-367
    • Siddhartha, T.S.1    Prasanthi, B.2    Santosh, T.3    Ratna, J.V.4
  • 51
    • 77952022545 scopus 로고    scopus 로고
    • HPLC method for measuring meropenem and biapenem concentrations in human peritoneal fluid and bile: Application to comparative pharmacokinetic investigations
    • Kameda K, Ikawa K, Ikeda K, Morikawa N, Nakashima A, Ohge H, Sueda T. 2010. HPLC method for measuring meropenem and biapenem concentrations in human peritoneal fluid and bile: application to comparative pharmacokinetic investigations. J Chromatogr Sci 48:406-411. https://doi.org/10.1093/chromsci/48.5.406.
    • (2010) J Chromatogr Sci , vol.48 , pp. 406-411
    • Kameda, K.1    Ikawa, K.2    Ikeda, K.3    Morikawa, N.4    Nakashima, A.5    Ohge, H.6    Sueda, T.7


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