Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 5, 2017, Pages 1075-1080

  Lehtinen, Sonja ^a,b   Blanquart, François ^b   Croucher, Nicholas J ^b   Turner, Paul ^a,c,e   Lipsitch, Marc ^d   Fraser, Christophe ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e Angkor Hospital for Children   (Cambodia)

Author keywords

Antibiotic resistance; Coexistence; Epistasis; Multistrain model; Streptococcus pneumoniae

Indexed keywords

CEFTRIAXONE; COTRIMOXAZOLE; ERYTHROMYCIN; PENICILLIN DERIVATIVE; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENETICS; BALANCING SELECTION; GENE LOCUS; GENETIC BACKGROUND; MATHEMATICAL MODEL; MOLECULAR EVOLUTION; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; BIOLOGICAL MODEL; CLASSIFICATION; COMPARATIVE STUDY; DRUG EFFECTS; EPISTASIS; GENE LINKAGE DISEQUILIBRIUM; GENETIC SELECTION; GENETICS; HETEROZYGOTE; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGY; PNEUMOCOCCAL INFECTION; TIME FACTOR;

CARRIER STATE; DRUG RESISTANCE, MICROBIAL; EPISTASIS, GENETIC; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; PNEUMOCOCCAL INFECTIONS; SELECTION, GENETIC; SEROGROUP; STREPTOCOCCUS PNEUMONIAE; TIME FACTORS;

EID: 85011005431     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1617849114     Document Type: Article

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