Prevention of breast cancer by recapitulation of pregnancy hormone levels

Breast Cancer Research

Volumn 6, Issue 1, 2003, Pages

  Tonetti, Debra A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Breast cancer; Estrogen; Pregnancy; Prevention; Progesterone

Indexed keywords

CARCINOGEN; ESTROGEN; ESTROGEN RECEPTOR; GESTAGEN; TAMOXIFEN;

ADOLESCENT; AGE; BREAST CANCER; CANCER HORMONE THERAPY; CANCER INCIDENCE; CANCER PREVENTION; CARCINOGENESIS; HORMONE BLOOD LEVEL; HUMAN; NONHUMAN; NOTE; PREGNANCY; RODENT MODEL;

EID: 85010723407     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr750     Document Type: Note

References (13)

1. Rajkumar L, Guzman RC, Yang J, Thordarson G, Talamantes F, Nandi S: Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments. Breast Cancer Res. 2004, 6: R31-R37. 10.1186/bcr734.
2. Sivaraman L, Stephens LC, Markaverich BM, Clark JA, Krnacik S, Conneely OM, O'Malley BW, Medina D: Hormone-induced refractoriness to mammary carcinogenesis in Wistar-Furth rats. Carcinogenesis. 1998, 19: 1573-1581. 10.1093/carcin/19.9.1573.
3. Guzman RC, Yang J, Rajkumar L, Thordarson G, Chen X, Nandi S: Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. Proc Natl Acad Sci USA. 1999, 96: 2520-2525. 10.1073/pnas.96.5.2520.
4. Yang J, Yoshizawa K, Nandi S, Tsubura A: Protective effects of pregnancy and lactation against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats. Carcino-genesis. 1999, 20: 623-628.
5. Russo J, Russo IH: Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence. Am J Pathol. 1980, 100: 497-512.
6. Sivaraman L, Medina D: Hormone-induced protection against breast cancer. J Mammary Gland Biol Neoplasia. 2002, 7: 77-92. 10.1023/A:1015774524076.
7. Russo J, Russo IH: Biological and molecular bases of mammary carcinogenesis. Lab Invest. 1987, 57: 112-137.
8. Medina D, Sivaraman L, Hilsenbeck SG, Conneely O, Ginger M, Rosen J, Omalle BW: Mechanisms of hormonal prevention of breast cancer. Ann N Y Acad Sci. 2001, 952: 23-35.
9. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N: Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998, 90: 1371-1388. 10.1093/jnci/90.18.1371.
10. Swanson SM, Christov K: Estradiol and progesterone can prevent rat mammary cancer when administered concomitantly with carcinogen but do not modify surviving tumor histology, estrogen receptor alpha status or Ha-ras mutation frequency. Anticancer Res. 2003, 23: 3207-3213.
11. King MC, Wieand S, Hale K, Lee M, Walsh T, Owens K, Tait J, Ford L, Dunn BK, Costantino J, Wickerham L, Wolmark N, Fisher B: Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial. JAMA. 2001, 286: 2251-2256. 10.1001/jama.286.18.2251.
12. Jernstrom H, Lerman C, Ghadirian P, Lynch HT, Weber B, Garber J, Daly M, Olopade OI, Foulkes WD, Warner E, Brunet JS, Narod SA: Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2. Lancet. 1999, 354: 1846-1850. 10.1016/S0140-6736(99)04336-6.
13. Wickerham DL: Tamoxifen's impact as a preventive agent in clinical practice and an update on the STAR trial. Recent Results Cancer Res. 2003, 163: 87-95.