The development of rapastinel (formerly GLYX-13); a rapid acting and long lasting antidepressant

Current Neuropharmacology

Volumn 15, Issue 1, 2017, Pages 47-56

  Moskal, Joseph R ^a,b   Burgdorf, Jeffrey S ^a   Stanton, Patric K ^c   Kroes, Roger A ^b   Disterhoft, John F ^d   Burch, Ronald M ^a   Khan, M Amin ^b  

^a Northwestern University   (United States)

^b Naurex Inc   (United States)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Antidepressant; Glycine site; GLYX 13; Major depressive disorder; NMDA receptor; Rapastinel; Rapid acting

Indexed keywords

NOOTROPIC AGENT; RAPASTINEL; ANTIDEPRESSANT AGENT; GLYX-13 PEPTIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OLIGOPEPTIDE;

AMINO ACID SEQUENCE; ANTIDEPRESSANT ACTIVITY; BLOOD BRAIN BARRIER; CHRONIC UNPREDICTABLE STRESS; COGNITIVE DEFECT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMOTIONALITY; FEAR; FORCED SWIM TEST; HUMAN; LEARNED HELPLESSNESS; LEARNING; MAJOR DEPRESSION; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; OPEN FIELD TEST; PHASE 2 CLINICAL TRIAL (TOPIC); REVIEW; AGE; ANIMAL; CHEMISTRY; DEPRESSION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; EXPLORATORY BEHAVIOR; LONG TERM POTENTIATION; MAZE TEST; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PRECLINICAL STUDY; RAT; SWIMMING; SYNAPSE; ULTRASTRUCTURE; VOCALIZATION;

AGE FACTORS; ANIMALS; ANTIDEPRESSIVE AGENTS; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EXPLORATORY BEHAVIOR; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY; NEURONAL PLASTICITY; OLIGOPEPTIDES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SWIMMING; SYNAPSES; VOCALIZATION, ANIMAL;

EID: 85010640119     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/1570159X14666160321122703     Document Type: Review

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