A randomized controlled trial of preoperative oral immunonutrition in patients undergoing surgery for colorectal cancer: hospital stay and health care costs;Estudio prospectivo y randomizado sobre inmunonutrición oral preoperatoria en pacientes intervenidos por cáncer colorrectal: estancia hospitalaria y costos sanitarios

Cirugia y Cirujanos (English Edition)

Volumn 85, Issue 5, 2017, Pages 393-400

  Manzanares Campillo, María del Carmen ^a   Martín Fernández, Jesús ^a   Amo Salas, Mariano ^b   Casanova Rituerto, Daniel ^c  

^a HOSPITAL GENERAL UNIVERSITARIO DE CIUDAD REAL   (Spain)

^b UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^c UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Colorectal cancer; Immunonutrition; Infectious complications

Indexed keywords

IMMUNONUTRITION; UNCLASSIFIED DRUG;

ARTICLE; COLON CANCER; COLORECTAL CANCER; CONTROLLED STUDY; HEALTH CARE COST; HOSPITALIZATION; HUMAN; INFECTIOUS COMPLICATION; LENGTH OF STAY; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECTUM CANCER; ADENOCARCINOMA; ADMINISTRATION AND DOSAGE; AGED; COLORECTAL TUMOR; COMPARATIVE STUDY; COMPLICATION; DIET THERAPY; ECONOMICS; ENTERIC FEEDING; FEMALE; IMMUNOLOGY; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATION; PREOPERATIVE CARE; PROCEDURES; PROTEIN CALORIE MALNUTRITION; PROTEIN INTAKE; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; DIETARY PROTEINS; ENTERAL NUTRITION; FEMALE; HEALTH CARE COSTS; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; PROSPECTIVE STUDIES; PROTEIN-ENERGY MALNUTRITION;

EID: 85010021976     PISSN: 00097411     EISSN: 2444054X     Source Type: Journal    
DOI: 10.1016/j.circir.2016.10.029     Document Type: Article

References (45)

1. Waitzberg, D.L., Ravacci, G.R., Raslan, M., Hospital hyponutrition. Nutr Hosp. 26 (2011), 254–264.
2. García, A., Álvarez, J., Planas, M.S., Burgos, R., Araujo, K., Multidisciplinary consensus on the approach to hospital malnutrition in Spain. Nutr Hosp. 26 (2011), 701–710.
3. Belda-Iniesta C, Castro J, Casado E, González M. Soporte nutricional en el paciente oncológico. Malnutrición y enfermedad neoplásica. [consultado 5 Abr 2011]. Disponible en: http://www.seom.org/seomcm/images/stories/recursos/infopublico/publicaciones/soporteNutricional/pdf/cap_03.pdf.
4. Cid, L., Fernández, T., Neira, P., Arias, J., Varela, J.J., Gómez, F.F., Hyponutrition prevalence among patients with digestive neoplasm before surgery. Nutr Hosp. 23 (2008), 46–53.
5. García-Luna, P.P., Parejo, J., Pereira, J.L., Causes and impact of hyponutrition and cachexia in the oncologic patient. Nutr Hosp 21:Suppl 3 (2006), 10–16.
6. Monti, G., Desnutrición hospitalaria: una patología subdiagnosticada. Revista de la Asociación Médica Argentina. 121 (2008), 25–28.
7. Schiesser, M., Muller, S., Kirchhoff, P., Breitenstein, S., Schafer, M., Clavien, P.A., Assessment of a novel screening score for nutritional risk in predicting complications in gastro-intestinal surgery. Clin Nutr. 27 (2008), 565–570.
8. Weimann, A., Braga, M., Harsanyi, L., Laviano, A., Ljungqvist, O., Soeters, P., et al. ESPEN Guidelines on enteral nutrition: Surgery including organ transplantation. Clin Nutr. 25 (2006), 224–244.
9. García-Caballero M, Calderón-Durán A, Martínez-Moreno M. En: García-Caballero M, ed. Inmunonutrición. ¿Modula la nutrición la respuesta inmune? Málaga: Servicio de Publicaciones de la Universidad de Málaga y Novartis Health Consumer S. A.; 2005. p. 41-49.
10. Crabtree, U., Inmunonutrición: segunda parte. Revista Gatrohnup. 12 (2010), 120–125.
11. Braga, M., Gianotti, L., Vignali, A., Schmid, A., Nespoli, L., Di Carlo, V., Hospital resources consumed for surgical morbidity: effects of preoperative arginine and omega-3 fatty acid supplementation on costs. Nutrition. 21:11-12 (2005), 1078–1086.
12. Gianotti, L., Braga, M., Frei, A., Greiner, R., di Carlo, V., Health care resources consumed to treat postoperative infections: cost saving by perioperative immunonutrition. Shock. 14 (2000), 325–330.
13. Gómez, C., Cantón, A., Luengo, L.M., Fuster, G.O., Efficacy, cost-effectiveness, and effects on quality of life of nutritional supplementation. Nutr Hosp. 25 (2010), 781–792.
14. Olveira, G., Tapia, M.J., Colomo, N., Costs versus benefits of oral nutritional supplements. Nutr Hosp. 24 (2009), 251–259.
15. Akbarshahi, H., Andersson, B., Norden, M., Andersson, R., Perioperative nutrition in elective gastrointestinal surgery-potential for improvement?. Dig Surg. 25 (2008), 165–174.
16. Gianotti, L., Braga, M., Nespoli, L., Radaelli, G., Beneduce, A., di Carlo, V., A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology. 122 (2002), 1763–1770.
17. Nakamura, K., Kariyazono, H., Komokata, T., Hamada, N., Sakata, R., Yamada, K., Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. Nutrition. 21 (2005), 639–649.
18. Cerantola, Y., Hubner, M., Grass, F., Demartines, N., Schafer, M., Immunonutrition in gastrointestinal surgery. Br J Surg. 98 (2010), 37–48.
19. Marimuthu, K., Varadhan, K.K., Ljungqvist, O., Lobo, D.N., A meta-analysis of the effect of combinations of immune modulating nutrients on outcome in patients undergoing major open gastrointestinal surgery. Ann Surg. 255 (2012), 1060–1068.
20. Osland, E., Hossain, M.B., Khan, S., Memon, M.A., Effect of timing of pharmaconutrition (immunonutrition) administration on outcomes of elective surgery for gastrointestinal malignancies: a systematic review and meta-analysis. J Parenter Enteral Nutr. JPEN. 38 (2014), 53–69.
21. Braga, M., Gianotti, L., Nespoli, L., Radaelli, G., di Carlo, V., Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch Surg. 137 (2002), 174–180.
22. Oguz, M., Kerem, M., Bedirli, A., Mentes, B.B., Sakrak, O., Salman, B., et al. L-alanin-L-glutamine supplementation improves the outcome after colorectal surgery for cancer. Colorectal Dis. 9 (2007), 515–520.
23. Braga, M., Gianotti, L., Vignali, A., Carlo, V.D., Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery. 132 (2002), 805–814.
24. Wu, G.H., Liu, Z.H., Wu, Z.H., Wu, Z.G., Perioperative artificial nutrition in malnourished gastrointestinal cancer patients. World J Gastroenterol. 12 (2006), 2441–2444.
25. Heys, S.D., Schofield, A.C., Wahle, K.W., Immunonutrition in clinical practice: what is the current evidence?. Nutr Hosp. 19 (2004), 325–332.
26. Gómez, M.B., García-Talavera, N.V., Sánchez, C., Zomeno, A.I., Hernández, M.N., Gómez, M.J., et al. Perioperative nutritional support in patients with colorectal neoplasms. Nutr Hosp. 25 (2010), 797–805.
27. Senkal, M., Kemen, M., Homann, H.H., Eickhoff, U., Baier, J., Zumtobel, V., Modulation of postoperative immune response by enteral nutrition with a diet enriched with arginine, RNA, and omega-3 fatty acids in patients with upper gastrointestinal cancer. Eur J Surg. 161 (1995), 115–122.
28. Okamoto, Y., Okano, K., Izuishi, K., Usuki, H., Wakabayashi, H., Suzuki, Y., Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg. 33 (2009), 1815–1821.
29. Zhang, Y., Gu, Y., Guo, T., Li, Y., Cai, H., Perioperative immunonutrition for gastrointestinal cancer: A systematic review of randomized controlled trials. Surg Oncol. 21 (2012), e87–e95.
30. Beale, R.J., Bryg, D.J., Bihari, D.J., Immunonutrition in the critically ill: a systematic review of clinical outcome. Crit Care Med. 27 (1999), 2799–2805.
31. Heyland, D.K., Novak, F., Drover, J.W., Jain, M., Su, X., Suchner, U., Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 286 (2001), 944–953.
32. Montejo, J.C., Zarazaga, A., López-Martínez, J., Urrutia, G., Roque, M., Blesa, A.L., et al. Immunonutrition in the intensive care unit. A systematic review and consensus statement. Clin Nutr. 22 (2003), 221–233.
33. Sacks, G.S., Genton, L., Kudsk, K.A., Controversy of immunonutrition for surgical critical-illness patients. Curr Opin Crit Care. 9 (2003), 300–305.
34. Zheng, Y., Li, F., Qi, B., Luo, B., Sun, H., Liu, S., et al. Application of perioperative immunonutrition for gastrointestinal surgery: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr 16:Suppl 1 (2007), 253–257.
35. Waitzberg, D.L., Saito, H., Plank, L.D., Jamieson, G.G., Jagannath, P., Hwang, T.L., et al. Postsurgical infections are reduced with specialized nutrition support. World J Surg. 30 (2006), 1592–1604.
36. Marik, P.E., Zaloga, G.P., Immunonutrition in high-risk surgical patients: a systematic review and analysis of the literature. Parenter Enteral Nutr. JPEN. 34 (2010), 378–386.
37. Mauskopf, J.A., Candrilli, S.D., Chevrou-Severac, H., Ochoa, J.B., Immunonutrition for patients undergoing elective surgery for gastrointestinal cancer: impact on hospital costs. World J Surg Oncol., 10, 2012, 136.
38. Steiner, C., Elixhauser, A., Schnaier, J., The healthcare cost and utilization project: an overview. Eff Clin Pract. 5 (2002), 143–151.
39. Healthcare Cost and Utilization Project (HCUP) Overview of the Nationwide Inpatient Sample (NIS). [consultado 5 Mar 2016]. Disponible en: http://www.hcup-us.ahrq.gov/nisoverview.jsp.
40. Febrer, L., Iglesias, C., Mercadal, J., Ribera, M., Cómo entender un análisis de coste-efectividad. Piel. 20 (2005), 172–176.
41. National Institute for Heath and Care Excellence (NICE). Surgical site infection. [consultado 5 Mar 2016]. Disponible en: https://www.nice.org.uk/guidance/QS49.
42. Stratton R, Russell C, Green C, Pan F. En: Elia M, ed. The cost of disease-related malnutrition in the UK and economic considerations for the use of oral nutritional supplements (ONS) in adults. United Kingdom: BAPEN. Advancing Clinical Nutrition. [consultado 5 Mar 2016]. Disponible en: http://www.bapen.org.uk/pdfs/health_econ_exec_sum.pdf.
43. Russell, C.A., The impact of malnutrition on healthcare costs and economic considerations for the use of oral nutritional supplements. Clin Nutr.(Suppl 1), 2007, 25–32.
44. Klek, S., Szybinski, P., Szczepanek, K., Perioperative immunonutrition in surgical cancer patients: A summary of a decade of research. World J Surg 38 (2014), 803–812.
45. Barker, L.A., Gray, C., Wilson, L., Thomson, B.N., Shedda, S., Crowe, T.C., Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: a randomised controlled trial. Eur J Clin Nutr. 67 (2013), 802–807.