메뉴 건너뛰기




Volumn 177, Issue 5, 2017, Pages 674-683

The aspirin story – from willow to wonder drug

Author keywords

acetylsalicylic acid; antiplatelet agent; aspirin; history; willow

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; DIAMORPHINE; INDOMETACIN; SALICIN; STREPTOKINASE; ANTIPYRETIC AGENT; ANTITHROMBOCYTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 85009959460     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.14520     Document Type: Review
Times cited : (216)

References (87)
  • 1
    • 33644878356 scopus 로고    scopus 로고
    • Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks
    • Aguilar, M. & Hart, R. (2005) Antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks. Cochrane Database of Systematic Reviews, 4, CD001925.
    • (2005) Cochrane Database of Systematic Reviews , vol.4 , pp. CD001925
    • Aguilar, M.1    Hart, R.2
  • 2
    • 34548650898 scopus 로고    scopus 로고
    • Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks
    • Aguilar, M.I., Hart, R. & Pearce, L.A. (2007) Oral anticoagulants versus antiplatelet therapy for preventing stroke in patients with non-valvular atrial fibrillation and no history of stroke or transient ischemic attacks. Cochrane Database of Systematic Reviews, 3, CD006186.
    • (2007) Cochrane Database of Systematic Reviews , vol.3 , pp. CD006186
    • Aguilar, M.I.1    Hart, R.2    Pearce, L.A.3
  • 3
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-term cancer incidence and metastases: a systematic comparison of evidence from observational studies versus randomised trials
    • Algra, A.M. & Rothwell, P.M. (2012) Effects of regular aspirin on long-term cancer incidence and metastases: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncology, 13, 518–527.
    • (2012) Lancet Oncology , vol.13 , pp. 518-527
    • Algra, A.M.1    Rothwell, P.M.2
  • 4
    • 84925348610 scopus 로고    scopus 로고
    • Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management
    • American Society of Anesthesiologists Task Force on Perioperative Blood Management. (2015) Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology, 122, 241–275.
    • (2015) Anesthesiology , vol.122 , pp. 241-275
  • 5
    • 84971579967 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy-I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists’ Collaboration. (1994a) Collaborative overview of randomised trials of antiplatelet therapy-I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ, 308, 81–106.
    • (1994) BMJ , vol.308 , pp. 81-106
  • 6
    • 0028128106 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy-II: maintenance of vascular graft or arterial patency by antiplatelet therapy
    • Antiplatelet Trialists’ Collaboration. (1994b) Collaborative overview of randomised trials of antiplatelet therapy-II: maintenance of vascular graft or arterial patency by antiplatelet therapy. BMJ, 308, 159–168.
    • (1994) BMJ , vol.308 , pp. 159-168
  • 7
    • 0028217263 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy-III: reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients
    • Antiplatelet Trialists’ Collaboration. (1994c) Collaborative overview of randomised trials of antiplatelet therapy-III: reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. BMJ, 308, 235–246.
    • (1994) BMJ , vol.308 , pp. 235-246
  • 10
    • 84975292439 scopus 로고    scopus 로고
    • Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. Preventive Services Task Force Recommendation Statement
    • Bibbins-Domingo, K.; U.S. Preventive Services Task Force. (2016) Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine, 164, 836–845.
    • (2016) Annals of Internal Medicine , vol.164 , pp. 836-845
    • Bibbins-Domingo, K.1
  • 11
    • 0000105161 scopus 로고
    • Su di un nuovo elemento morfologico del sangue dei mammiferi e sulla sua importanza nella trombosi e nella coagulazione
    • Bizzozero, G. (1882) Su di un nuovo elemento morfologico del sangue dei mammiferi e sulla sua importanza nella trombosi e nella coagulazione. Osservatore Gazetta delle Cliniche, 17, 785–787.
    • (1882) Osservatore Gazetta delle Cliniche , vol.17 , pp. 785-787
    • Bizzozero, G.1
  • 12
    • 0346367328 scopus 로고
    • Aggregation of blood platelets by adenosine diphosphate and its reversal
    • Born, G.V. (1962) Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature, 194, 927–929.
    • (1962) Nature , vol.194 , pp. 927-929
    • Born, G.V.1
  • 15
    • 84980115863 scopus 로고
    • Analgesic antipyretic drugs as antagonists of bradykinin
    • Collier, H.O.J. & Shorley, P.G. (1970) Analgesic antipyretic drugs as antagonists of bradykinin. British Journal of Pharmacology, 15, 601–610.
    • (1970) British Journal of Pharmacology , vol.15 , pp. 601-610
    • Collier, H.O.J.1    Shorley, P.G.2
  • 16
    • 0009322367 scopus 로고
    • Acetylsalicylic acid, possible preventive of coronary thrombosis
    • Craven, L.L. (1950a) Acetylsalicylic acid, possible preventive of coronary thrombosis. Annals of Western Medicine and Surgery, 4, 95.
    • (1950) Annals of Western Medicine and Surgery , vol.4 , pp. 95
    • Craven, L.L.1
  • 17
    • 34447557421 scopus 로고
    • Coronary artery thrombosis can be prevented
    • Craven, L.L. (1950b) Coronary artery thrombosis can be prevented. Journal of Insurance Medicine, 5, 47–48.
    • (1950) Journal of Insurance Medicine , vol.5 , pp. 47-48
    • Craven, L.L.1
  • 18
    • 33845462556 scopus 로고
    • Experiences with aspirin (acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis
    • Craven, L.L. (1953) Experiences with aspirin (acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. Mississippi Valley Medical Journal, 75, 38–44.
    • (1953) Mississippi Valley Medical Journal , vol.75 , pp. 38-44
    • Craven, L.L.1
  • 19
    • 0000144179 scopus 로고
    • Prevention of coronary and cerebral thrombosis
    • Craven, L.L. (1956) Prevention of coronary and cerebral thrombosis. Mississippi Valley Medical Journal, 78, 213–215.
    • (1956) Mississippi Valley Medical Journal , vol.78 , pp. 213-215
    • Craven, L.L.1
  • 20
    • 84970833216 scopus 로고
    • Some recent advances in medical diagnosis and treatment
    • Douthwaite, A.H. (1938) Some recent advances in medical diagnosis and treatment. British Medical Journal, 1, 1143–1146.
    • (1938) British Medical Journal , vol.1 , pp. 1143-1146
    • Douthwaite, A.H.1
  • 21
    • 50349119142 scopus 로고
    • Gastroscopic observations of the gastric mucosa after use of aspirin
    • Douthwaite, A. & Lintott, G.A.M. (1938) Gastroscopic observations of the gastric mucosa after use of aspirin. Lancet, 2, 1222–1225.
    • (1938) Lancet , vol.2 , pp. 1222-1225
    • Douthwaite, A.1    Lintott, G.A.M.2
  • 22
    • 0000767482 scopus 로고
    • 50 Jahre Aspirin
    • Eichengrün, A. (1949) 50 Jahre Aspirin. Pharmazie, 4, 582–584.
    • (1949) Pharmazie , vol.4 , pp. 582-584
    • Eichengrün, A.1
  • 26
    • 84977256843 scopus 로고
    • Untersuchungen über die wasserfreien organischen Säuren
    • Gerhardt, C.H. (1853) Untersuchungen über die wasserfreien organischen Säuren. Justus Liebigs Annalen der Chemie, 87, 149–179.
    • (1853) Justus Liebigs Annalen der Chemie , vol.87 , pp. 149-179
    • Gerhardt, C.H.1
  • 29
    • 80052599858 scopus 로고    scopus 로고
    • Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit
    • Hearnshaw, S.A., Logan, R.F., Lowe, D., Travis, S.P., Murphy, M.F. & Palmer, K.R. (2011) Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut, 60, 1327–1335.
    • (2011) Gut , vol.60 , pp. 1327-1335
    • Hearnshaw, S.A.1    Logan, R.F.2    Lowe, D.3    Travis, S.P.4    Murphy, M.F.5    Palmer, K.R.6
  • 30
    • 0017094438 scopus 로고
    • Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme
    • Hemler, M., Lands, W.E. & Smith, W.L. (1976) Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme. Journal of Biological Chemistry, 251, 5575–5579.
    • (1976) Journal of Biological Chemistry , vol.251 , pp. 5575-5579
    • Hemler, M.1    Lands, W.E.2    Smith, W.L.3
  • 31
    • 0023805341 scopus 로고
    • Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group
    • ISIS-2 Collaborative Group. (1988) Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet, 2, 349–360.
    • (1988) Lancet , vol.2 , pp. 349-360
  • 33
    • 84858283382 scopus 로고    scopus 로고
    • Guidelines on the investigation and management of antiphospholipid syndrome
    • Keeling, D., Mackie, I., Moore, G.W., Greer, I.A. & Greaves, M.; British Committee for Standards in Haematology. (2012) Guidelines on the investigation and management of antiphospholipid syndrome. British Journal of Haematology, 157, 47–58.
    • (2012) British Journal of Haematology , vol.157 , pp. 47-58
    • Keeling, D.1    Mackie, I.2    Moore, G.W.3    Greer, I.A.4    Greaves, M.5
  • 36
    • 50249190686 scopus 로고
    • The use of aspirin and Sod. Sal
    • Lancet Editorial. (1935) The use of aspirin and Sod. Sal. Lancet, 226, 619–620.
    • (1935) Lancet , vol.226 , pp. 619-620
  • 39
    • 84989186785 scopus 로고    scopus 로고
    • Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature
    • Le Quellec, S., Bordet, J.C., Negrier, C. & Dargaud, Y. (2016) Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response. A review of the literature. Thrombosis and Haemostasis, 116, 638–650.
    • (2016) Thrombosis and Haemostasis , vol.116 , pp. 638-650
    • Le Quellec, S.1    Bordet, J.C.2    Negrier, C.3    Dargaud, Y.4
  • 44
    • 34248324434 scopus 로고    scopus 로고
    • Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study
    • Lovelock, C.E., Molyneux, A.J. & Rothwell, P.M.; Oxford Vascular Study. (2007) Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study. Lancet Neurology, 6, 487–493.
    • (2007) Lancet Neurology , vol.6 , pp. 487-493
    • Lovelock, C.E.1    Molyneux, A.J.2    Rothwell, P.M.3
  • 46
    • 50449202956 scopus 로고
    • The treatment of acute rheumatism by salicin
    • 342–343
    • MacLagan, T. (1876a) The treatment of acute rheumatism by salicin. Lancet, I, 342–343 & 383–384.
    • (1876) Lancet , vol.I , pp. 383-384
    • MacLagan, T.1
  • 47
    • 50449201532 scopus 로고
    • The treatment of acute rheumatism by salicin
    • MacLagan, T. (1876b) The treatment of acute rheumatism by salicin. Lancet, I, 585.
    • (1876) Lancet , vol.I , pp. 585
    • MacLagan, T.1
  • 48
    • 48249092794 scopus 로고
    • The willow as a remedy for acute rheumatism
    • MacLagan, T. (1876c) The willow as a remedy for acute rheumatism. Lancet, I, 910.
    • (1876) Lancet , vol.I , pp. 910
    • MacLagan, T.1
  • 51
    • 3943055418 scopus 로고
    • Varicella with hypoglycaemia possibly due to salicylates
    • Mortimer, E.A. (1962) Varicella with hypoglycaemia possibly due to salicylates. American Journal of Diseases in Children, 103, 583–590.
    • (1962) American Journal of Diseases in Children , vol.103 , pp. 583-590
    • Mortimer, E.A.1
  • 52
    • 84952775835 scopus 로고    scopus 로고
    • NICE guideline CG68. Available online at, (Accessed 27th December 2016)
    • National Institute for Health and Care Excellence. (2008) Stroke and transient ischaemic attack in over 16s: diagnosis and initial management. NICE guideline CG68. Available online at: https://www.nice.org.uk/Guidance/cg68. (Accessed 27th December 2016).
    • (2008) Stroke and transient ischaemic attack in over 16s: diagnosis and initial management
  • 54
    • 84957963976 scopus 로고    scopus 로고
    • NICE guideline CG180. Available online at, (Accessed 27th December 2016)
    • National Institute for Health and Care Excellence. (2014) Atrial fibrillation: management. NICE guideline CG180. Available online at: https://www.nice.org.uk/guidance/cg180. (Accessed 27th December 2016).
    • (2014) Atrial fibrillation: management
  • 55
    • 85019778335 scopus 로고    scopus 로고
    • Available online at, (Accessed 27th December 2016)
    • National Institute for Health and Care Excellence. (2015) Antiplatelet treatment. NICE clinical knowledge summary. Available online at: http://cks.nice.org.uk/antiplatelet-treatment. (Accessed 27th December 2016).
    • (2015) Antiplatelet treatment. NICE clinical knowledge summary
  • 56
    • 0001332609 scopus 로고
    • Platelet aggregation: part I. Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness
    • O'Brien, J.R. (1962) Platelet aggregation: part I. Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness. Journal of Clinical Pathology, 15, 446–452.
    • (1962) Journal of Clinical Pathology , vol.15 , pp. 446-452
    • O'Brien, J.R.1
  • 57
    • 0001213294 scopus 로고
    • Some effects of adrenaline and anti-adrenaline compounds on platelets in vitro and in vivo
    • O'Brien, J.R. (1963) Some effects of adrenaline and anti-adrenaline compounds on platelets in vitro and in vivo. Nature, 200, 763–764.
    • (1963) Nature , vol.200 , pp. 763-764
    • O'Brien, J.R.1
  • 60
    • 0031760604 scopus 로고    scopus 로고
    • Platelet-active drugs: the relationships among dose, effectiveness, and side effects
    • Patrono, C., Coller, B., Dalen, J.E., Fuster, V., Gent, M., Harker, L.A., Hirsh, J. & Roth, G. (1998) Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest, 114, 470S–488S.
    • (1998) Chest , vol.114 , pp. 470S-488S
    • Patrono, C.1    Coller, B.2    Dalen, J.E.3    Fuster, V.4    Gent, M.5    Harker, L.A.6    Hirsh, J.7    Roth, G.8
  • 61
    • 4644289299 scopus 로고    scopus 로고
    • Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
    • Patrono, C., Coller, B., FitzGerald, G.A., Hirsh, J. & Roth, G. (2004) Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest, 126, 234S–264S.
    • (2004) Chest , vol.126 , pp. 234S-264S
    • Patrono, C.1    Coller, B.2    FitzGerald, G.A.3    Hirsh, J.4    Roth, G.5
  • 62
    • 0018892610 scopus 로고
    • Aspirin after myocardial infarction
    • Peto, R. (1980) Aspirin after myocardial infarction. Lancet, I, 1172–1173.
    • (1980) Lancet , vol.I , pp. 1172-1173
    • Peto, R.1
  • 63
    • 0014664886 scopus 로고
    • Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs
    • Piper, P.J. & Vane, J.R. (1969) Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature, 223, 29–35.
    • (1969) Nature , vol.223 , pp. 29-35
    • Piper, P.J.1    Vane, J.R.2
  • 64
    • 0005444411 scopus 로고
    • Sur la composition de la Salicine et sur quelques-unes de ses reactions
    • Piria, R. (1838) Sur la composition de la Salicine et sur quelques-unes de ses reactions. Comptes Rendues de l'Académie des Sciences, Paris. 6, 338.
    • (1838) Comptes Rendues de l'Académie des Sciences, Paris , vol.6 , pp. 338
    • Piria, R.1
  • 66
    • 0034655567 scopus 로고    scopus 로고
    • Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: pulmonary embolism prevention (PEP) trial
    • Pulmonary Embolism Prevention Trial Collaborative Group. (2000) Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: pulmonary embolism prevention (PEP) trial. Lancet, 355, 1295–1302.
    • (2000) Lancet , vol.355 , pp. 1295-1302
  • 67
    • 0013951558 scopus 로고
    • Salicylates and bleeding: the aspirin tolerance test
    • Quick, A.J. (1966) Salicylates and bleeding: the aspirin tolerance test. American Journal of Medical Sciences, 252, 265–269.
    • (1966) American Journal of Medical Sciences , vol.252 , pp. 265-269
    • Quick, A.J.1
  • 68
    • 0023137593 scopus 로고
    • Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs
    • Reilly, I.A. & FitzGerald, G.A. (1987) Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. Blood, 69, 180–186.
    • (1987) Blood , vol.69 , pp. 180-186
    • Reilly, I.A.1    FitzGerald, G.A.2
  • 70
    • 78650215449 scopus 로고    scopus 로고
    • Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    • Rothwell, P.M., Wilson, M., Elwin, C.E., Norrving, B., Algra, A., Warlow, C.P. & Meade, T.W. (2010) Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet, 376, 1741–1750.
    • (2010) Lancet , vol.376 , pp. 1741-1750
    • Rothwell, P.M.1    Wilson, M.2    Elwin, C.E.3    Norrving, B.4    Algra, A.5    Warlow, C.P.6    Meade, T.W.7
  • 73
    • 0002887772 scopus 로고
    • Ein heizbarer Objecttisch und seine Verwendung bei Untersuchungen des Blutes
    • Schultze, M. (1865) Ein heizbarer Objecttisch und seine Verwendung bei Untersuchungen des Blutes. Archiv für Mikroscopische Anatomie, 1, 1–42.
    • (1865) Archiv für Mikroscopische Anatomie , vol.1 , pp. 1-42
    • Schultze, M.1
  • 74
    • 34547808148 scopus 로고    scopus 로고
    • Cryosupernatant and solvent detergent fresh-frozen plasma (Octaplas) usage at a single centre in acute thrombotic thrombocytopenic purpura
    • Scully, M., Longair, I., Flynn, M., Berryman, J. & Machin, S.J. (2007) Cryosupernatant and solvent detergent fresh-frozen plasma (Octaplas) usage at a single centre in acute thrombotic thrombocytopenic purpura. Vox Sanguinis, 93, 154–158.
    • (2007) Vox Sanguinis , vol.93 , pp. 154-158
    • Scully, M.1    Longair, I.2    Flynn, M.3    Berryman, J.4    Machin, S.J.5
  • 75
    • 84863841323 scopus 로고    scopus 로고
    • Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies
    • Scully, M., Hunt, B.J., Benjamin, S., Liesner, R., Rose, P., Peyvandi, F., Cheung, B. & Machin, S.J.; for the British Committee for Standards in Haematology. (2012) Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. British Journal of Haematology, 158, 323–335.
    • (2012) British Journal of Haematology , vol.158 , pp. 323-335
    • Scully, M.1    Hunt, B.J.2    Benjamin, S.3    Liesner, R.4    Rose, P.5    Peyvandi, F.6    Cheung, B.7    Machin, S.J.8
  • 76
    • 84920861919 scopus 로고    scopus 로고
    • How World War 1 changed global attitudes to war and infectious diseases
    • Shanks, G.D. (2014) How World War 1 changed global attitudes to war and infectious diseases. Lancet, 384, 1699–1707.
    • (2014) Lancet , vol.384 , pp. 1699-1707
    • Shanks, G.D.1
  • 78
    • 0034707245 scopus 로고    scopus 로고
    • The discovery of aspirin: a reappraisal
    • Sneader, W. (2000) The discovery of aspirin: a reappraisal. BMJ, 321, 1591–1594.
    • (2000) BMJ , vol.321 , pp. 1591-1594
    • Sneader, W.1
  • 79
    • 0001187267 scopus 로고
    • An account of the succefs of the bark of the willow in the cure of agues
    • Stone, E. (1763) An account of the succefs of the bark of the willow in the cure of agues. Philosophical Transactions, 53, 195–200.
    • (1763) Philosophical Transactions , vol.53 , pp. 195-200
    • Stone, E.1
  • 80
    • 0018138512 scopus 로고
    • A randomized trial of aspirin and sulfinpyrazone in threatened stroke
    • The Canadian Cooperative Study Group. (1978) A randomized trial of aspirin and sulfinpyrazone in threatened stroke. New England Journal of Medicine, 299, 53–59.
    • (1978) New England Journal of Medicine , vol.299 , pp. 53-59
  • 81
    • 0026072561 scopus 로고
    • A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischaemic attack or minor ischemic stroke
    • The Dutch TIA Trial Study Group. (1991) A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischaemic attack or minor ischemic stroke. New England Journal of Medicine, 325, 1261–1266.
    • (1991) New England Journal of Medicine , vol.325 , pp. 1261-1266
  • 82
    • 0025751563 scopus 로고
    • Swedish aspirin low-dose trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events
    • The SALT Collaborative Group. (1991) Swedish aspirin low-dose trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet, 338, 1345–1349.
    • (1991) Lancet , vol.338 , pp. 1345-1349
  • 84
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature: New Biology, 231, 232–235.
    • (1971) Nature: New Biology , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 86
    • 0014190795 scopus 로고
    • Impaired platelet-connective-tissue reaction in man after aspirin ingestion
    • Weiss, H.J. & Aledort, L.M. (1967) Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet, 2, 495–497.
    • (1967) Lancet , vol.2 , pp. 495-497
    • Weiss, H.J.1    Aledort, L.M.2
  • 87
    • 84924326183 scopus 로고    scopus 로고
    • From plant extract to molecular panacea: a commentary on Stone (1763) ‘An account of the success of the bark of the willow in the cure of the agues’
    • Wood, J.N. (2015) From plant extract to molecular panacea: a commentary on Stone (1763) ‘An account of the success of the bark of the willow in the cure of the agues’. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 370, pii:20140317.
    • (2015) Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences , vol.370
    • Wood, J.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.