Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management

Kidney International

Volumn 91, Issue 4, 2017, Pages 937-947

  Bierzynska, Agnieszka ^a   McCarthy, Hugh J ^a   Soderquest, Katrina ^b   Sen, Ethan S ^a   Colby, Elizabeth ^a   Ding, Wen Y ^a   Nabhan, Marwa M ^c   Kerecuk, Larissa ^d   Hegde, Shivram ^e   Hughes, David ^f   Marks, Stephen ^g   Feather, Sally ^h   Jones, Caroline ⁱ   Webb, Nicholas J A ^j   Ognjanovic, Milos ^k   Christian, Martin ^l   Gilbert, Rodney D ^m   Sinha, Manish D ⁿ   Lord, Graham M ^b   Simpson, Michael ^b   Koziell, Ania B ^b   Welsh, Gavin I ^a   Saleem, Moin A ^a   more..

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CAIRO UNIVERSITY   (Egypt)

^d BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^e UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^f ROYAL HOSPITAL FOR CHILDREN   (United Kingdom)

^g GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^h ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

ⁱ ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

^j UNIVERSITY OF MANCHESTER   (United Kingdom)

^k NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^l NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^m UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

ⁿ GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

cytoskeleton; focal segmental glomerulosclerosis; nephrotic syndrome; pediatric nephrology; podocyte; proteinuria

Indexed keywords

ALPHA ACTININ 4; NEPHRIN; PODOCIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; WT1 PROTEIN; MEMBRANE PROTEIN; SIGNAL PEPTIDE; WT1 PROTEIN, HUMAN;

ACTN4 GENE; ADULT; ALLELE; APOL1 GENE; ARTICLE; CHRONIC KIDNEY FAILURE; COHORT ANALYSIS; COL4A3 GENE; CONGENITAL NEPHROTIC SYNDROME; CONTROLLED STUDY; DGKE GENE; FAMILY HISTORY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOMICS; HISTOPATHOLOGY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NPHS1 GENE; NPHS2 GENE; OCRL GENE; ONSET AGE; PATIENT IDENTIFICATION; PERSONALIZED MEDICINE; PHENOTYPE; RECURRENCE RISK; TRPC6 GENE; WHOLE EXOME SEQUENCING; WT1 GENE; ADOLESCENT; CHILD; DISEASE COURSE; EXOME; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; HEREDITY; HIGH THROUGHPUT SEQUENCING; INFANT; KAPLAN MEIER METHOD; KIDNEY; KIDNEY FAILURE, CHRONIC; MUTATION; NEPHROTIC SYNDROME; PATHOLOGY; PEDIGREE; PREDICTIVE VALUE; PRESCHOOL CHILD; PROCEDURES; PROGNOSIS; REGISTER; RISK FACTOR; UNITED KINGDOM; YOUNG ADULT;

ADOLESCENT; AGE OF ONSET; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE PROGRESSION; EXOME; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HEREDITY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFANT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; KIDNEY; KIDNEY FAILURE, CHRONIC; MALE; MEMBRANE PROTEINS; MUTATION; NEPHROTIC SYNDROME; PEDIGREE; PHENOTYPE; PRECISION MEDICINE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REGISTRIES; RISK FACTORS; UNITED KINGDOM; WT1 PROTEINS; YOUNG ADULT;

EID: 85009788825     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.10.013     Document Type: Article

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