-
1
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, et al: Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783-792, 2001.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
2
-
-
33845886440
-
Lapatinib plus capecitabine for HER2- positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, et al: Lapatinib plus capecitabine for HER2- positive advanced breast cancer. N Engl J Med 355:2733-2743, 2006.
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
-
3
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
Baselga J, Cortés J, Kim SB, et al: Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 366:109-119, 2012.
-
(2012)
N Engl J Med
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Cortés, J.2
Kim, S.B.3
-
4
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
Verma S, Miles D, Gianni L, et al: Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 367:1783-1791, 2012.
-
(2012)
N Engl J Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
-
5
-
-
84905842097
-
Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guideline
-
Giordano SH, Temin S, Kirshner JJ, et al: Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 32: 2078-2099, 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2078-2099
-
-
Giordano, S.H.1
Temin, S.2
Kirshner, J.J.3
-
6
-
-
84876011018
-
Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Hurvitz SA, Dirix L, Kocsis J, et al: Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 31: 1157-1163, 2013.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1157-1163
-
-
Hurvitz, S.A.1
Dirix, L.2
Kocsis, J.3
-
7
-
-
84902973417
-
Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2-positive, locally advanced, or metastatic breast cancer
-
Miller KD, Diéras V, Harbeck N, et al: Phase IIa trial of trastuzumab emtansine with pertuzumab for patients with human epidermal growth factor receptor 2-positive, locally advanced, or metastatic breast cancer. J Clin Oncol 32: 1437-1444, 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1437-1444
-
-
Miller, K.D.1
Diéras, V.2
Harbeck, N.3
-
8
-
-
85009887737
-
Trastuzumab emtansine with or without pertuzumab versus trastuzumab plus taxane for human epidermal growth factor receptor 2-positive advanced breast cancer: Primary results from the phase III MARIANNE study
-
Perez EA, Barrios C, Eiermann W, et al: Trastuzumab emtansine with or without pertuzumab versus trastuzumab plus taxane for human epidermal growth factor receptor 2-positive advanced breast cancer: Primary results from the phase III MARIANNE study. J Clin Oncol 35:141-148, 2017.
-
(2017)
J Clin Oncol
, vol.35
, pp. 141-148
-
-
Perez, E.A.1
Barrios, C.2
Eiermann, W.3
-
9
-
-
84879477431
-
AVEREL: A randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer
-
Gianni L, Romieu GH, Lichinitser M, et al: AVEREL: A randomized phase III Trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J Clin Oncol 31:1719-1725, 2013.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1719-1725
-
-
Gianni, L.1
Romieu, G.H.2
Lichinitser, M.3
-
10
-
-
84937523280
-
Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): A phase 3, randomised, double-blind, multicentre trial
-
Hurvitz SA, Andre F, Jiang Z, et al: Combination of everolimus with trastuzumab plus paclitaxel as first-line treatment for patients with HER2-positive advanced breast cancer (BOLERO-1): A phase 3, randomised, double-blind, multicentre trial. Lancet Oncol 16:816-829, 2015.
-
(2015)
Lancet Oncol
, vol.16
, pp. 816-829
-
-
Hurvitz, S.A.1
Andre, F.2
Jiang, Z.3
-
11
-
-
79951982754
-
Multicenter phase III randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (BCIRG 007 study): Two highly active therapeutic regimens
-
Valero V, Forbes J, Pegram MD, et al: Multicenter phase III randomized trial comparing docetaxel and trastuzumab with docetaxel, carboplatin, and trastuzumab as first-line chemotherapy for patients with HER2-gene-amplified metastatic breast cancer (BCIRG 007 study): Two highly active therapeutic regimens. J Clin Oncol 29:149-156, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 149-156
-
-
Valero, V.1
Forbes, J.2
Pegram, M.D.3
-
12
-
-
79951974161
-
Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as firstline therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA study
-
Andersson M, Lidbrink E, Bjerre K, et al: Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as firstline therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA study. J Clin Oncol 29:264-271, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 264-271
-
-
Andersson, M.1
Lidbrink, E.2
Bjerre, K.3
-
13
-
-
84923052492
-
Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
-
Swain SM, Baselga J, Kim S-B, et al: Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 372:724-734, 2015.
-
(2015)
N Engl J Med
, vol.372
, pp. 724-734
-
-
Swain, S.M.1
Baselga, J.2
Kim, S.-B.3
-
14
-
-
34347395733
-
Trastuzumab-Mechanism of action and use in clinical practice
-
Hudis CA: Trastuzumab-Mechanism of action and use in clinical practice. N Engl J Med 357:39-51, 2007.
-
(2007)
N Engl J Med
, vol.357
, pp. 39-51
-
-
Hudis, C.A.1
-
15
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips GD, Li G, Dugger DL, et al: Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. Cancer Res 68:9280-9290, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
Li, G.2
Dugger, D.L.3
-
16
-
-
85009769121
-
Pathologic complete response (PCR) rates after neoadjuvant trastuzumab emtansine (T-DM1 [K]) 1 pertuzumab (P) vs docetaxel 1 carboplatin 1 trastuzumab 1 P (TCHP) treatment in patients with HER2-positive (HER21) early breast cancer (EBC) (KRISTINE)
-
suppl; abstr 500
-
Hurvitz SA, Martin M, Symmans WF, et al: Pathologic complete response (pCR) rates after neoadjuvant trastuzumab emtansine (T-DM1 [K]) 1 pertuzumab (P) vs docetaxel 1 carboplatin 1 trastuzumab 1 P (TCHP) treatment in patients with HER2-positive (HER21) early breast cancer (EBC) (KRISTINE). J Clin Oncol 34, 2016 (suppl; abstr 500).
-
(2016)
J Clin Oncol
, vol.34
-
-
Hurvitz, S.A.1
Martin, M.2
Symmans, W.F.3
-
17
-
-
79952092706
-
Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
-
Burris HA III, Rugo HS, Vukelja SJ, et al: Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol 29:398-405, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 398-405
-
-
Burris, H.A.1
Rugo, H.S.2
Vukelja, S.J.3
-
18
-
-
84964307819
-
High HER2 expression correlates with response to the combination of lapatinib and trastuzumab
-
Scaltriti M, Nuciforo P, Bradbury I, et al: High HER2 expression correlates with response to the combination of lapatinib and trastuzumab. Clin Cancer Res 21: 569-576, 2015.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 569-576
-
-
Scaltriti, M.1
Nuciforo, P.2
Bradbury, I.3
-
19
-
-
84904343628
-
Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: A randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer
-
Perez EA, Hurvitz SA, Amler LC, et al: Relationship between HER2 expression and efficacy with first-line trastuzumab emtansine compared with trastuzumab plus docetaxel in TDM4450g: A randomized phase II study of patients with previously untreated HER2-positive metastatic breast cancer. Breast Cancer Res 16:R50, 2014.
-
(2014)
Breast Cancer Res
, vol.16
, pp. R50
-
-
Perez, E.A.1
Hurvitz, S.A.2
Amler, L.C.3
-
20
-
-
84911926434
-
Biomarker analyses in CLEOPATRA: A phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer
-
Baselga J, Cortés J, Im SA, et al: Biomarker analyses in CLEOPATRA: A phase III, placebo-controlled study of pertuzumab in human epidermal growth factor receptor 2-positive, first-line metastatic breast cancer. J Clin Oncol 32: 3753-3761, 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3753-3761
-
-
Baselga, J.1
Cortés, J.2
Im, S.A.3
-
21
-
-
84896776546
-
Trastuzumab emtansine: Mechanisms of action and drug resistance
-
Barok M, Joensuu H, Isola J: Trastuzumab emtansine: Mechanisms of action and drug resistance. Breast Cancer Res 16:209, 2014.
-
(2014)
Breast Cancer Res
, vol.16
, pp. 209
-
-
Barok, M.1
Joensuu, H.2
Isola, J.3
-
22
-
-
84892168048
-
Trastuzumab emtansine: A novel antibody-drug conjugate for HER2-positive breast cancer
-
Krop I, Winer EP: Trastuzumab emtansine: A novel antibody-drug conjugate for HER2-positive breast cancer. Clin Cancer Res 20:15-20, 2014.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 15-20
-
-
Krop, I.1
Winer, E.P.2
-
23
-
-
84906819100
-
Trastuzumab emtansine in human epidermal growth factor receptor 2-positive metastatic breast cancer: An integrated safety analysis
-
Diéras V, Harbeck N, Budd GT, et al: Trastuzumab emtansine in human epidermal growth factor receptor 2-positive metastatic breast cancer: An integrated safety analysis. J Clin Oncol 32:2750-2757, 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2750-2757
-
-
Diéras, V.1
Harbeck, N.2
Budd, G.T.3
-
24
-
-
84901639476
-
Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): A randomised, open-label, phase 3 trial
-
Krop IE, Kim SB, Gonźalez-Martín A, et al: Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): A randomised, open-label, phase 3 trial. Lancet Oncol 15: 689-699, 2014.
-
(2014)
Lancet Oncol
, vol.15
, pp. 689-699
-
-
Krop, I.E.1
Kim, S.B.2
Gonźalez-Martín, A.3
-
25
-
-
84922384344
-
Phase II study of paclitaxel given once per week along with trastuzumab and pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
Dang C, Iyengar N, Datko F, et al: Phase II study of paclitaxel given once per week along with trastuzumab and pertuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 33: 442-447, 2015.
-
(2015)
J Clin Oncol
, vol.33
, pp. 442-447
-
-
Dang, C.1
Iyengar, N.2
Datko, F.3
-
27
-
-
78751610848
-
Iniparib plus chemotherapy in metastatic triple-negative breast cancer
-
O'Shaughnessy J, Osborne C, Pippen JE, et al: Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 364:205-214, 2011.
-
(2011)
N Engl J Med
, vol.364
, pp. 205-214
-
-
O'Shaughnessy, J.1
Osborne, C.2
Pippen, J.E.3
-
28
-
-
84912105634
-
Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer
-
O'Shaughnessy J, Schwartzberg L, Danso MA, et al: Phase III study of iniparib plus gemcitabine and carboplatin versus gemcitabine and carboplatin in patients with metastatic triple-negative breast cancer. J Clin Oncol 32:3840-3847, 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3840-3847
-
-
O'Shaughnessy, J.1
Schwartzberg, L.2
Danso, M.A.3
-
29
-
-
84911943039
-
Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer
-
Saura C, Garcia-Saenz JA, Xu B, et al: Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 32:3626-3633, 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 3626-3633
-
-
Saura, C.1
Garcia-Saenz, J.A.2
Xu, B.3
-
30
-
-
85009751929
-
Efficacy results of a phase 1b study of ont-380, a CNS-penetrant TKI, in combination with T-DM1 in HER21 metastatic breast cancer (MBC), including patients (pts) with brain metastases
-
suppl; abstr 513
-
Borges VF, Ferrario C, Aucoin N, et al: Efficacy results of a phase 1b study of ont-380, a CNS-penetrant TKI, in combination with T-DM1 in HER21 metastatic breast cancer (MBC), including patients (pts) with brain metastases. J Clin Oncol 34, 2016 (suppl; abstr 513).
-
(2016)
J Clin Oncol
, vol.34
-
-
Borges, V.F.1
Ferrario, C.2
Aucoin, N.3
-
31
-
-
84900434047
-
Pertuzumab in the treatment of HER21 breast cancer
-
Jhaveri K, Esteva FJ: Pertuzumab in the treatment of HER21 breast cancer. J Natl Compr Canc Netw 12:591-598, 2014.
-
(2014)
J Natl Compr Canc Netw
, vol.12
, pp. 591-598
-
-
Jhaveri, K.1
Esteva, F.J.2
-
32
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata Y, Lan KH, Zhou X, et al: PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6:117-127, 2004.
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
Lan, K.H.2
Zhou, X.3
-
33
-
-
84980338826
-
Relationship between tumor biomarkers and efficacy in EMILIA, a phase III study of trastuzumab emtansine in HER2-positive metastatic breast cancer
-
Baselga J, Lewis Phillips GD, Verma S, et al: Relationship between tumor biomarkers and efficacy in EMILIA, a phase III study of trastuzumab emtansine in HER2-positive metastatic breast cancer. Clin Cancer Res 22:3755-3763, 2016.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 3755-3763
-
-
Baselga, J.1
Lewis Phillips, G.D.2
Verma, S.3
-
34
-
-
84986627812
-
Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. Treatment of physician's choice in previously treated HER2-positive advanced breast cancer
-
Kim SB, Wildiers H, Krop IE, et al: Relationship between tumor biomarkers and efficacy in TH3RESA, a phase III study of trastuzumab emtansine (T-DM1) vs. treatment of physician's choice in previously treated HER2-positive advanced breast cancer. Int J Cancer 139:2336-2342, 2016.
-
(2016)
Int J Cancer
, vol.139
, pp. 2336-2342
-
-
Kim, S.B.1
Wildiers, H.2
Krop, I.E.3
|