Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

eLife

Volumn 5, Issue , 2016, Pages

  Abedini, Andisheh ^a   Plesner, Annette ^a   Cao, Ping ^a   Ridgway, Zachary ^a   Zhang, Jinghua ^a   Tu, Ling Hsien ^a   Middleton, Chris T ^a   Chao, Brian ^a   Sartori, Daniel J ^a   Meng, Fanling ^a   Wang, Hui ^a   Wong, Amy G ^a   Zanni, Martin T ^a   Verchere, C Bruce ^a   Raleigh, Daniel P ^a   Schmidt, Ann Marie ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

amylin; amyloid; biochemistry; biophysics; diabetes; IAPP; islet amyloid polypeptide; mouse; oligomer; rat; structural biology

Indexed keywords

AMYLIN; AMYLOID PROTEIN; REACTIVE OXYGEN METABOLITE;

AMYLOIDOSIS; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; INFLAMMATION; METABOLISM; MOUSE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; RAT; TIME FACTOR;

AMYLOIDOGENIC PROTEINS; AMYLOIDOSIS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; INFLAMMATION; INSULIN-SECRETING CELLS; ISLET AMYLOID POLYPEPTIDE; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 85009453255     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.12977     Document Type: Article

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