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Volumn 49, Issue 2, 2017, Pages 224-232

Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae: pharmacodynamics and morphological changes

Author keywords

Combination; Klebsiella pneumoniae; KPC carbapenemase; Meropenem; Pharmacodynamics; Polymyxin B

Indexed keywords

MEROPENEM; POLYMYXIN B; ANTIINFECTIVE AGENT; CARBAPENEM DERIVATIVE; THIENAMYCIN DERIVATIVE;

EID: 85009266839     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2016.10.025     Document Type: Article
Times cited : (48)

References (39)
  • 1
    • 79958818528 scopus 로고    scopus 로고
    • Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention
    • [1] Gupta, N., Limbago, B.M., Patel, J.B., Kallen, A.J., Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis 53 (2011), 60–67.
    • (2011) Clin Infect Dis , vol.53 , pp. 60-67
    • Gupta, N.1    Limbago, B.M.2    Patel, J.B.3    Kallen, A.J.4
  • 2
    • 84866072596 scopus 로고    scopus 로고
    • Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy
    • [2] Tumbarello, M., Viale, P., Viscoli, C., Trecarichi, E.M., Tumietto, F., Marchese, A., et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis 55 (2012), 943–950.
    • (2012) Clin Infect Dis , vol.55 , pp. 943-950
    • Tumbarello, M.1    Viale, P.2    Viscoli, C.3    Trecarichi, E.M.4    Tumietto, F.5    Marchese, A.6
  • 4
    • 85011064618 scopus 로고    scopus 로고
    • Antibiotic/antimicrobial resistance: biggest threats
    • CDC Atlanta (GA)
    • [4] US Centers for Disease Control and Prevention, Antibiotic/antimicrobial resistance: biggest threats. 2013, CDC, Atlanta (GA).
    • (2013)
    • US Centers for Disease Control and Prevention1
  • 6
    • 33747191088 scopus 로고    scopus 로고
    • In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase
    • e95–8
    • [6] Elliott, E., Brink, A.J., van Greune, J., Els, Z., Woodford, N., Turton, J., et al. In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum β-lactamase. Clin Infect Dis, 42, 2006 e95–8.
    • (2006) Clin Infect Dis , vol.42
    • Elliott, E.1    Brink, A.J.2    van Greune, J.3    Els, Z.4    Woodford, N.5    Turton, J.6
  • 7
    • 84883312604 scopus 로고    scopus 로고
    • Polymyxins and doripenem combination against KPC-producing Klebsiella pneumoniae
    • [7] Lee, G.C., Burgess, D.S., Polymyxins and doripenem combination against KPC-producing Klebsiella pneumoniae. J Clin Med Res 5 (2013), 97–100.
    • (2013) J Clin Med Res , vol.5 , pp. 97-100
    • Lee, G.C.1    Burgess, D.S.2
  • 8
    • 84898983354 scopus 로고    scopus 로고
    • Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae
    • [8] Velkov, T., Deris, Z.Z., Huang, J.X., Azad, M.A.K., Butler, M., Sivanesan, S., et al. Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae. Innate Immun 20 (2014), 350–363.
    • (2014) Innate Immun , vol.20 , pp. 350-363
    • Velkov, T.1    Deris, Z.Z.2    Huang, J.X.3    Azad, M.A.K.4    Butler, M.5    Sivanesan, S.6
  • 10
    • 85006224666 scopus 로고    scopus 로고
    • Extensively drug-resistant Acinetobacter baumannii in a Thai hospital: a molecular epidemiologic analysis and identification of bactericidal polymyxin B-based combinations
    • [10] Teo, J., Lim, T.-P., Hsu, L.-Y., Tan, T.-Y., Sasikala, S., Hon, P.-Y., et al. Extensively drug-resistant Acinetobacter baumannii in a Thai hospital: a molecular epidemiologic analysis and identification of bactericidal polymyxin B-based combinations. Antimicrob Resist Infect Control 4 (2015), 1–7.
    • (2015) Antimicrob Resist Infect Control , vol.4 , pp. 1-7
    • Teo, J.1    Lim, T.-P.2    Hsu, L.-Y.3    Tan, T.-Y.4    Sasikala, S.5    Hon, P.-Y.6
  • 11
    • 0024459602 scopus 로고
    • Antibacterial activity of meropenem against Gram-negative bacteria with a permeability defect and against staphylococci
    • [11] Kitzis, M.D., Acar, J.F., Gutmann, L., Antibacterial activity of meropenem against Gram-negative bacteria with a permeability defect and against staphylococci. J Antimicrob Chemother 24:Suppl. A (1989), 125–132.
    • (1989) J Antimicrob Chemother , vol.24 , pp. 125-132
    • Kitzis, M.D.1    Acar, J.F.2    Gutmann, L.3
  • 12
    • 84938382440 scopus 로고    scopus 로고
    • A space–time model for carbapenemase-producing Klebsiella pneumoniae (KPC) cluster quantification in a high-complexity hospital
    • [12] Abboud, C.S., Monteiro, J., Franca, J.I., Pignatari, A.C., De Souza, E.E., Camargo, E.C., et al. A space–time model for carbapenemase-producing Klebsiella pneumoniae (KPC) cluster quantification in a high-complexity hospital. Epidemiol Infect 143 (2015), 2648–2652.
    • (2015) Epidemiol Infect , vol.143 , pp. 2648-2652
    • Abboud, C.S.1    Monteiro, J.2    Franca, J.I.3    Pignatari, A.C.4    De Souza, E.E.5    Camargo, E.C.6
  • 14
    • 84926489004 scopus 로고    scopus 로고
    • The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae
    • [14] Poirel, L., Jayol, A., Bontron, S., Villegas, M.-V., Ozdamar, M., Türkoglu, S., et al. The mgrB gene as a key target for acquired resistance to colistin in Klebsiella pneumoniae. J Antimicrob Chemother 70 (2015), 75–80.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 75-80
    • Poirel, L.1    Jayol, A.2    Bontron, S.3    Villegas, M.-V.4    Ozdamar, M.5    Türkoglu, S.6
  • 15
    • 84891742685 scopus 로고    scopus 로고
    • Performance standards for antimicrobial susceptibility testing; twenty-third informational supplement
    • Document M100-S23. Wayne (PA): CLSI
    • [15] Clinical and Laboratory Standards Institute, Performance standards for antimicrobial susceptibility testing; twenty-third informational supplement. Document M100-S23. Wayne (PA): CLSI, 2013.
    • (2013)
    • Clinical and Laboratory Standards Institute1
  • 16
    • 84979714204 scopus 로고    scopus 로고
    • Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0
    • Available from [Accessed 7 December 2016]
    • [16] European Committee on Antimicrobial Susceptibility Testing, Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0. Available from http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_6.0_Breakpoint_table.pdf, 2016 [Accessed 7 December 2016].
    • (2016)
    • European Committee on Antimicrobial Susceptibility Testing1
  • 17
  • 18
    • 84880939299 scopus 로고    scopus 로고
    • Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens
    • [18] Sandri, A.M., Landersdorfer, C.B., Jacob, J., Boniatti, M.M., Dalarosa, M.G., Falci, D.R., et al. Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens. Clin Infect Dis 57 (2013), 524–531.
    • (2013) Clin Infect Dis , vol.57 , pp. 524-531
    • Sandri, A.M.1    Landersdorfer, C.B.2    Jacob, J.3    Boniatti, M.M.4    Dalarosa, M.G.5    Falci, D.R.6
  • 19
    • 16244372376 scopus 로고    scopus 로고
    • Comparison of the pharmacodynamics of meropenem in patients with ventilator-associated pneumonia following administration by 3-hour infusion or bolus injection
    • [19] Jaruratanasirikul, S., Sriwiriyajan, S., Punyo, J., Comparison of the pharmacodynamics of meropenem in patients with ventilator-associated pneumonia following administration by 3-hour infusion or bolus injection. Antimicrob Agents Chemother 49 (2005), 1337–1339.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1337-1339
    • Jaruratanasirikul, S.1    Sriwiriyajan, S.2    Punyo, J.3
  • 21
    • 84984850920 scopus 로고    scopus 로고
    • Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii
    • [21] Rao, G.G., Ly, N.S., Diep, J., Forrest, A., Bulitta, J.B., Holden, P.N., et al. Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii. Int J Antimicrob Agents 48 (2016), 331–336.
    • (2016) Int J Antimicrob Agents , vol.48 , pp. 331-336
    • Rao, G.G.1    Ly, N.S.2    Diep, J.3    Forrest, A.4    Bulitta, J.B.5    Holden, P.N.6
  • 22
    • 85011841148 scopus 로고    scopus 로고
    • Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus
    • pii: e00119-16
    • [22] Zhao, J., Cheah, S.-E., Roberts, K.D., Nation, R.L., Thompson, P.E., Velkov, T., et al. Transcriptomic analysis of the activity of a novel polymyxin against Staphylococcus aureus. mSphere, 1, 2016, 10.1128/mSphere.00119-16 pii: e00119-16.
    • (2016) mSphere , vol.1
    • Zhao, J.1    Cheah, S.-E.2    Roberts, K.D.3    Nation, R.L.4    Thompson, P.E.5    Velkov, T.6
  • 24
    • 79953851292 scopus 로고    scopus 로고
    • What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline
    • [24] Livermore, D.M., Warner, M., Mushtaq, S., Doumith, M., Zhang, J., Woodford, N., What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline. Int J Antimicrob Agents 37 (2011), 415–419.
    • (2011) Int J Antimicrob Agents , vol.37 , pp. 415-419
    • Livermore, D.M.1    Warner, M.2    Mushtaq, S.3    Doumith, M.4    Zhang, J.5    Woodford, N.6
  • 25
    • 0026802197 scopus 로고
    • Agents that increase the permeability of the outer membrane
    • [25] Vaara, M., Agents that increase the permeability of the outer membrane. Microbiol Rev 56 (1992), 395–411.
    • (1992) Microbiol Rev , vol.56 , pp. 395-411
    • Vaara, M.1
  • 26
    • 42049110124 scopus 로고    scopus 로고
    • Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa
    • [26] Davies, T.A., Shang, W., Bush, K., Flamm, R.K., Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother 52 (2008), 1510–1512.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1510-1512
    • Davies, T.A.1    Shang, W.2    Bush, K.3    Flamm, R.K.4
  • 27
    • 84876217985 scopus 로고    scopus 로고
    • Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design
    • [27] Landersdorfer, C.B., Ly, N.S., Xu, H., Tsuji, B.T., Bulitta, J.B., Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design. Antimicrob Agents Chemother 57 (2013), 2343–2351.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2343-2351
    • Landersdorfer, C.B.1    Ly, N.S.2    Xu, H.3    Tsuji, B.T.4    Bulitta, J.B.5
  • 28
    • 84861481150 scopus 로고    scopus 로고
    • Incidence and predictors of acute kidney injury associated with intravenous polymyxin B therapy
    • [28] Kubin, C.J., Ellman, T.M., Phadke, V., Haynes, L.J., Calfee, D.P., Yin, M.T., Incidence and predictors of acute kidney injury associated with intravenous polymyxin B therapy. J Infect 65 (2012), 80–87.
    • (2012) J Infect , vol.65 , pp. 80-87
    • Kubin, C.J.1    Ellman, T.M.2    Phadke, V.3    Haynes, L.J.4    Calfee, D.P.5    Yin, M.T.6
  • 29
    • 0030995958 scopus 로고    scopus 로고
    • The pharmacology of meropenem, a new carbapenem antibiotic
    • S266–75
    • [29] Craig, W.A., The pharmacology of meropenem, a new carbapenem antibiotic. Clin Infect Dis, 24(Suppl. 2), 1997 S266–75.
    • (1997) Clin Infect Dis , vol.24
    • Craig, W.A.1
  • 30
    • 84858627056 scopus 로고    scopus 로고
    • Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens
    • [30] Qureshi, Z.A., Paterson, D.L., Potoski, B.A., Kilayko, M.C., Sandovsky, G., Sordillo, E., et al. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother 56 (2012), 2108–2113.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 2108-2113
    • Qureshi, Z.A.1    Paterson, D.L.2    Potoski, B.A.3    Kilayko, M.C.4    Sandovsky, G.5    Sordillo, E.6
  • 31
    • 84978328513 scopus 로고    scopus 로고
    • Treatment options for carbapenem-resistant Enterobacteriaceae infections
    • ofv050
    • [31] Morrill, H.J., Pogue, J.M., Kaye, K.S., LaPlante, K.L., Treatment options for carbapenem-resistant Enterobacteriaceae infections. Open Forum Infect Dis, 2, 2015 ofv050.
    • (2015) Open Forum Infect Dis , vol.2
    • Morrill, H.J.1    Pogue, J.M.2    Kaye, K.S.3    LaPlante, K.L.4
  • 32
    • 67449090359 scopus 로고    scopus 로고
    • Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution
    • [32] Roberts, J.A., Kirkpatrick, C.M., Roberts, M.S., Robertson, T.A., Dalley, A.J., Lipman, J., Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother 64 (2009), 142–150.
    • (2009) J Antimicrob Chemother , vol.64 , pp. 142-150
    • Roberts, J.A.1    Kirkpatrick, C.M.2    Roberts, M.S.3    Robertson, T.A.4    Dalley, A.J.5    Lipman, J.6
  • 33
    • 84896940320 scopus 로고    scopus 로고
    • Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems
    • [33] Daikos, G.L., Tsaousi, S., Tzouvelekis, L.S., Anyfantis, I., Psichogiou, M., Argyropoulou, A., et al. Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems. Antimicrob Agents Chemother 58 (2014), 2322–2328.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 2322-2328
    • Daikos, G.L.1    Tsaousi, S.2    Tzouvelekis, L.S.3    Anyfantis, I.4    Psichogiou, M.5    Argyropoulou, A.6
  • 34
    • 84898970487 scopus 로고    scopus 로고
    • Probing the penetration of antimicrobial polymyxin lipopeptides into Gram-negative bacteria
    • [34] Deris, Z.Z., Swarbrick, J.D., Roberts, K.D., Azad, M.A.K., Akter, J., Horne, A.S., et al. Probing the penetration of antimicrobial polymyxin lipopeptides into Gram-negative bacteria. Bioconjug Chem 25 (2014), 750–760.
    • (2014) Bioconjug Chem , vol.25 , pp. 750-760
    • Deris, Z.Z.1    Swarbrick, J.D.2    Roberts, K.D.3    Azad, M.A.K.4    Akter, J.5    Horne, A.S.6
  • 35
    • 0014447679 scopus 로고
    • Electron microscopic studies on mode of action of polymyxin
    • [35] Koike, M., Iida, K., Matsuo, T., Electron microscopic studies on mode of action of polymyxin. J Bacteriol 97 (1969), 448–452.
    • (1969) J Bacteriol , vol.97 , pp. 448-452
    • Koike, M.1    Iida, K.2    Matsuo, T.3
  • 36
    • 84946759595 scopus 로고    scopus 로고
    • Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two ‘old’ antibiotics—polymyxin B and chloramphenicol
    • [36] Abdul Rahim, N., Cheah, S.-E., Johnson, M.D., Yu, H., Sidjabat, H.E., Boyce, J., et al. Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two ‘old’ antibiotics—polymyxin B and chloramphenicol. J Antimicrob Chemother 70 (2015), 2589–2597.
    • (2015) J Antimicrob Chemother , vol.70 , pp. 2589-2597
    • Abdul Rahim, N.1    Cheah, S.-E.2    Johnson, M.D.3    Yu, H.4    Sidjabat, H.E.5    Boyce, J.6
  • 39
    • 84963770499 scopus 로고    scopus 로고
    • Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae
    • [39] Arena, F., De Angelis, L.H., Cannatelli, A., Di Pilato, V., Amorese, M., D'Andrea, M.M., et al. Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae. Antimicrob Agents Chemother 60 (2016), 2509–2512.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 2509-2512
    • Arena, F.1    De Angelis, L.H.2    Cannatelli, A.3    Di Pilato, V.4    Amorese, M.5    D'Andrea, M.M.6


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