Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of neomycin sulfate

International Journal of Biological Macromolecules

Volumn 97, Issue , 2017, Pages 218-227

  Jabeen, Sehrish ^a,b   Islam, Atif ^b   Ghaffar, Abdul ^a,b   Gull, Nafisa ^b   Hameed, Ayesha ^b   Bashir, Anbreen ^a,b   Jamil, Tahir ^b   Hussain, Tousif ^c  

^a UNIVERSITY OF ENGINEERING AND TECHNOLOGY   (Pakistan)

^b UNIVERSITY OF THE PUNJAB   (Pakistan)

^c GC UNIVERSITY   (Pakistan)

Author keywords

Alginate; Chitosan; Injectable hydrogels; Neomycin sulfate; Swelling; Tetraethoxysilane

Indexed keywords

ALGINIC ACID; CHITOSAN; DISTILLED WATER; NEOMYCIN; POLYMER; POLYVINYL ALCOHOL; SILANE; TETRAETHOXYSILANE; ANTIINFECTIVE AGENT; BUFFER; DELAYED RELEASE FORMULATION; DRUG CARRIER; HYDROGEL; SILANE DERIVATIVE; WATER;

ARTICLE; CELL VIABILITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; INTESTINE FLUID; NONHUMAN; PH; SCANNING ELECTRON MICROSCOPY; STOMACH JUICE; THERMOGRAVIMETRY; THERMOSTABILITY; ULTRAVIOLET SPECTROSCOPY; CHEMISTRY; DELAYED RELEASE FORMULATION; HELA CELL LINE; HUMAN; INJECTION; PHARMACOLOGY; TOXICITY;

ANTI-BACTERIAL AGENTS; BUFFERS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HELA CELLS; HUMANS; HYDROGELS; INJECTIONS; NEOMYCIN; SILANES; WATER;

EID: 85009107928     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2017.01.014     Document Type: Article

References (58)

1. [1] Ju, H.K., Kim, S.Y., Kim, S.J., Lee, Y.M., pH/temperatue-responsive semi- IPN hydrogels composed of alginate and poly(N-isopropylacrylamide). J. Appl. Polym. Sci. 83 (2002), 1128–1139.
2. [2] Qu, X., Wirsen, A., Albertsson, A.-C., Novel pH-sensitive chitosan hydrogels: swelling behaviour and states of water. Polymer 41 (2000), 4589–4598.
3. [3] Gao, C., Gao, Q., Li, Y., Rahaman, M.N., Teramato, A., Abe, K., Preparation and in vitro characterization of electrospun PVA scaffolds coated with bioactive glass for bone regeneration. J. Biomed. Mater. Res. A 100A (2012), 1324–1334.
4. [4] Chen, J., Park, K., Synthesis and charactrization of superporous hydrogel composites. J. Control. Release 65 (2000), 73–82.
5. [5] Peppas, N.A., Bures, P., Leobandug, W., Ichikawa, H., Hydrogels in pharmaccutical formulations. Eur. J. Pharm. Biopharm. 50 (2000), 27–46.
6. [6] Ghaffar, A., Draaisma, G.J.J., Mihov, G., Dias, A.A., Schoenmakers, P.J., van der Wal, S.j., Monitoring the in vitro enzyme-mediated degradation of degradable poly(ester amide) for controlled drug delivery by LC-ToF-MS. Biomacromolecues 12 (2011), 3243–3251.
7. [7] Muzzarelli, R.A.A., Natural Chelating Polymers; Alginic Acid, Chitin and Chitosan. 1973, Pergaman Press, New York, 83.
8. [8] Yang, C.-H., Wang, L.-S., Chen, S.-Y., Huang, M.-C., Li, Y.-H., Lin, Y.-C., Chen, P.-F., Shaw, J.-F., Huang, K.-S., Microfluidic assisted synthesis of silver nanoparticle-chitosan composite microparticles for antibacterial applications. Int. J. Pharm. 510 (2016), 493–500.
9. [9] Zikakis, J.P.E., Chitin, Chitosan and Related Enzymes. 2012, Academic Press Inc., London, 448.
10. [10] Shigemasa, Y., Minami, S., Applications of chitin and chitosan for biomaterials. Biotechnol. Genet. Eng. Rev. 13 (2013), 383–420.
11. [11] Dong, Y.M., Qiu, W.B., Tuan, Y.H., Wu, Y.S., Wang, M.A., Xu, C.Y., Influence of molecular weight on critical concentration of chitosanformic acid liquid crystalline solution. Polym. J. 33 (2001), 387–389.
12. [12] Payne, G.F., Sun, W.-Q., Sohrabi, A., Tyrosinase reaction/chitosan adsorption for selectively removing phenols from aqueous mixtures. Biotechnol. Bioeng. 40 (1992), 1011–1018.
13. [13] Ma, G., Yang, D., Su, D., Mu, X., Kennedy, J.F., Nie, J., Preparation and properties of water-soluble chitosan and polyvinyl alcohol blend films as potential bone tissue engineering matrix. Polym. Adv. Technol. 21 (2010), 189–195.
14. [14] Gorochovceva, N., Makuška, R., Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers. Eur. Polym. J. 40 (2004), 685–691.
15. [15] Hu, Y., Jiang, H., Xu, C., Wang, Y., Zhu, K., Preparation and characterization of poly(ethylene glycol)-g-chitosan with water- and organosolubility. Carbohydr. Polym. 61 (2005), 472–479.
16. [16] Wang, W., Du, Y., Qu, Y., Wang, X., Hu, Y., Yang, J., Cai, J., Kennedy, J.F., A new green technology for direct production of low molecular weight chitosan. Carbohydr. Polym. 74 (2008), 127–132.
17. [17] Ito, T., Yoshida, C., Murakami, Y., Design of novel sheet-shaped chitosan hydrogel for wound healing: a hybrid biomaterial consisting of both PEG-grafted chitosan and crosslinkable polymeric micelles acting as drug containers. Mater. Sci. Eng. C 33 (2013), 3697–3703.
18. [18] Li, J., Huang, Q., Rheological properties of chitosan-tripolyphosphate complexes: from suspensions to microgels. Carbohydr. Polym. 87 (2012), 1670–1677.
19. [19] Hu, B., Wang, S.S., Li, J., Zeng, X.X., Huang, Q.R., Assembly of bioactive peptide-chitosan nanocomplexes. J. Phys. Chem. B 115 (2011), 7515–7523.
20. [20] Atkins, E.D.T., Mackie, W., Smolko, E.E., Crystalline structure of alginic acids. Nature (London), 1970, 626–628.
21. [21] Kim, K.Y., Lee, S.Y., Min, D.S., Cho, Y.J., Chung, Y.H., Kim, J.M., Park, J.H., Sung, Y.K., Cho, C.S., Synthesis and evaluation of copoly(chitosan-g-N-carbobenzoxy-L-Lysine) for wound covering materials. Polymer, 1990, 427.
22. [22] Atkins, E.D.T., Mackie, W., Parker, K.D., Smolko, E.E., Crystalline structure of poly-D-manuronic and poly-L-guluronic acids. J. Polym. Sci. B: Polym. Lett. 9 (1971), 311–316.
23. [23] McDowell, R.H., The manufacture and properties of alginates. CIBA Rev. 1 (1961), 3–12.
24. [24] Chippada, U., Non-Intrusive Characterization of Properties of Hydrogels. A Doctorate Dissertation. 2010, 1–174.
25. [25] Maitra, J., Singh, N., Swelling behaviour of starch chitosan polymeric blend. Adv. Polym. Sci. Technol.: Int. J. 4 (2014), 22–27.
26. [26] Maitra, J., Shukla, V.M., Crosslinking in hydrogels—a review. Am. J. Polym. Sci. 4 (2014), 25–31.
27. [27] Xu, Y., Ding, W., Liu, J., Li, Y., Kennedy, J.F., Gu, Q., Shao, S., Preparation and characterization of organic-soluble acetylated starch nanocrystals. Carbohydr. Polym. 80 (2010), 1078–1084.
28. [28] Chifiriuc, C.M., Grumezescu, A.M., Saviuc, C., Croitoru, C., Mihaiescu, D.E., Lazar, V., Improved antibacterial activity of cephalosporins loaded in magnetic chitosan microspheres. Int. J. Pharm. 436 (2012), 201–205.
29. [29] Grumezescu, A.M., Andronescu, E., Holban, A.M., Ficai, A., Ficai, D., Voicu, G., Grumezescu, V., Balauree, P.C., Chifiriuc, C.M., Water dispersible cross-linked magnetic chitosan beads for increasing the antimicrobial efficiency of aminoglycoside antibiotics. Int. J. Pharm. 454 (2013), 233–240.
30. [30] McNeely, W.H., Kovacs, P., The physiological effects of alginates and Xanthum gum. In physiological effects of food carbohydrates. ACS Symposium, American Chemical Society, Washington, DC, 1975, 269–281.
31. [31] Torres, N.I., Noll, K.S., Xu, S., Li, J., Huang, Q., Sinko, P.J., Wachsman, M.B., Chikindas, M.L., Safety, formulation, and in vitro antiviral activity of the antimicrobial peptide subtilosin against herpes simplex virus type 1. Probiot. Antimicrob. Proteins 5 (2013), 26–35.
32. [32] Liang, S., Liu, L., Huang, Q., Yam, K.L., Preparation of single or double—network chitosan/poly(vinyl alcohol) gel films through selectively cross-linking method. Carbohydr. Polym. 77 (2009), 718–724.
33. [33] Rasool, N., Yasin, T., Heng, J.Y.Y., Akhter, Z., Synthesis and characterization of novel pH-, ionic strength and temperature-sensitive hydrogel for insulin delivery. Polymer 51 (2010), 1687–1693.
34. [34] Islam, A., Yain, T., Bano, I., Riaz, M., Controlled release of aspirin from pH-sensitive chitosan/poly(vinyl alcohol) hydrogel. J. Appl. Polym. Sci. 124 (2011), 4184–4192.
35. [35] Jena, K.K., Raju, K.V.S.N., Synthesis and characterization of hyperbranched polyurethane hybrids using tetraethoxysilane (TEOS) as cross-linker. Ind. Eng. Chem. Res. 47 (2008), 9214–9224.
36. [36] Hou, Q., Bank, P.A., Shakesheff, K.M., Injectable scaffolds for tissue regeneration. J. Mater. Chem. 14 (2004), 1915–1923.
37. [37] Lee, S.Y., Tae, G., Formulation and in vitro characterization of an in situ gelable, photo-polymerizable Pluronic hydrogel suitable for injection. J. Control. Release 119 (2007), 313–319.
38. [38] Hoare, T.R., Kohane, D.S., Hydrogels in drug delivery: progress and challenges. Polymer 49 (2008), 1993–2007.
39. [39] Kadajji, V.G., Betageri, G.V., Water soluble polymers for pharmaceutical applications. Polymers 3 (2011), 1972–2009.
40. [40] James, H.P., John, R., Alex, A., Anoop, K.R., Smart polymers for the controlled delivery of drugs—a concise overview. Acta Pharm. Sin. B 4 (2014), 120–127.
41. [41] Livingood, C.S., Nilasena, S., King, W.C., Stevenson, R.A., Mullins, J.F., Pyogenic infections treated with neomycin. J. Am. Med. Assoc. 148 (1952), 334–339.
42. [42] Adams, E., Schepers, R., Roets, E., Hoogmartens, J., Determination of neomycin sulfate by liquid chromatography with pulsed electrochemical detection. J. Chromatogr. A 741 (1996), 233–240.
43. [43] Mir, S., Yasin, T., Halley, P.J., Siddiqi, H.M., Nicholson, T., Thermal rheological, mechanical and morphological behavior of HDPE/chitosan blend. Carbohydr. Polym. 83 (2014), 414–421.
44. [44] Islam, A., Riaz, M., Yasin, T., Structural and viscoelastic properties of chitosan-based hydrogel and its drug delivery application. Int. J. Biol. Macromol. 59 (2013), 119–124.
45. [45] Islam, A., Yasin, T., Controlled delivery of drug from pH sensitive chitosan/poly(vinyl alcohol) blend. Carbohydr. Polym. 88 (2012), 1055–1060.
46. [46] Ma, G., Yang, D., Zhou, Y., Xiao, M., Kennedy, J.F., Nie, J., Preparation and characterization of water-soluble N-alkylated chitosan. Carbohydr. Polym. 74 (2008), 121–126.
47. [47] Kamoun, E.A., Kenawy, E.-R.S., Tamer, T.M., El-Meligy, M.A., Eldin, M.S.M., Poly(vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: characterization and bio-evaluation. Arab. J. Chem. 8 (2015), 38–47.
48. [48] Kamoun, E.A., Chen, X., Eldin, M.S.M., Kenawy, E.-R.S., Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: a review of remarkably blended polymers. Arab. J. Chem. 8 (2015), 1–14.
49. [49] Santos, C., Silva, C.J., Büttel, Z., Guimarães, R., Pereira, S.B., Tamagnini, P., Zille, A., Preparation and characterization of polysaccharides/PVA blend nanofibrous membranes by electrospinning method. Carbohydr. Polym. 99 (2014), 584–592.
50. [50] Hench, L.L., Biomaterials: a forecast for the future. Biomaterials 19 (1998), 14–19.
51. [51] Buranachai, T., Praphairaksit, N., Muangsin, N., Chitosan/polyethylene glycol beads crosslinked with tripolyphosphate and glutaraldehyde for gastrointestinal drug delivery. AAPS PharmSciTech 11 (2010), 1128–1137.
52. [52] Honary, S., Hoseinzadeh, B., Shalchian, P., The effect of polymer molecular weight on citrate crosslinked chitosan films for site-specific delivery of a non-polar drug. Trop. J. Pharm. Res. 9 (2010), 525–531.
53. [53] Pieróg, M., Ostrowska-Czubenko, J., Gierszewska-Drużyńska, M., Thermal degradation of double crosslinked hydrogel chitosan membranes. Progress Chem. Appl. Chitin 17 (2012), 69–74.
54. [54] Eldin, M.S.M., Kamoun, E.A., Sofan, M.A., Elbayomi, S.M., L-Arginine grafted alginate hydrogel beads: a novel pH-sensitive system for specific protein delivery. Arab. J. Chem. 8 (2015), 355–365.
55. [55] Straccia, M.C., Gomez d'Ayala, G., Romano, I., Oliva, A., Laurienzo, P., Alginate hydrogels coated with chitosan for wound dressing. Mar. Drugs 13 (2015), 2890–2908.
56. [56] Rashidzadeh, A., Olad, A., Salari, D., Reyhanitabar, A., On the preparation and swelling properties of hydrogel nanocomposite based on sodium alginate-g-poly(acrylic acid-co-acryl amide)/clinoptilolite and its application as slow release fertilizer. J. Polym. Res. 21 (2014), 344–358.
57. [57] Atta, S., Khaliq, S., Islam, A., Javeria, I., Jamil, T., Athar, M.A., Shafiq, M.I., Ghaffar, A., Injectable biopolymer based hydrogels for drug delivery applications. Int. J. Biol. Macromol. 80 (2015), 240–245.
58. [58] Repetto, G., Peso, A.d., Zurita, J.L., Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat. Protoc. 3 (2008), 1125–1131.