Filamentous bacteriophage produced by Pseudomonas aeruginosa alters the inflammatory response and promotes noninvasive infection in vivo

Infection and Immunity

Volumn 85, Issue 1, 2017, Pages

  Secor, Patrick R ^a   Michaels, Lia A ^a,e   Smigiel, Kate S ^b   Rohani, Maryam G ^b   Jennings, Laura K ^a   Hisert, Katherine B ^a   Arrigoni, Allison ^c   Braun, Kathleen R ^c   Birkland, Timothy P ^b   Lai, Ying ^a   Hallstrand, Teal S ^a   Bollyky, Paul L ^d   Singh, Pradeep K ^a   Parks, William C ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c BENAROYA RESEARCH INSTITUTE   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NEVADA   (United States)

Author keywords

Bacteriophages; Cystic fibrosis; Dissemination; Inflammation; Lung infection; Macrophages; Neutrophils; Pseudomonas aeruginosa

Indexed keywords

CXCL1 CHEMOKINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 1BETA; MESSENGER RNA; MUCIN;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL CLEARANCE; BACTERIAL COUNT; BACTERIAL LOAD; BACTERIOPHAGE; BACTERIUM ADHERENCE; BIOFILM; CONTROLLED STUDY; CYTOTOXICITY; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFECTION; INFLAMMATION; INFLAMMATORY INFILTRATE; LUNG EDEMA; LUNG HEMORRHAGE; LUNG HOMOGENATE; LUNG LAVAGE; MACROPHAGE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PF BACTERIOPHAGE; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RESPIRATORY EPITHELIUM; TWITCHING MOTILITY; VIRUS MORPHOLOGY; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CYSTIC FIBROSIS; GROWTH, DEVELOPMENT AND AGING; INOVIRUS; LUNG; MICROBIOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALS; BIOFILMS; CYSTIC FIBROSIS; INFLAMMATION; INOVIRUS; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 85009106961     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00648-16     Document Type: Article

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