Replacement of porcine CD163 scavenger receptor cysteine-rich domain 5 with a CD163- like homolog confers resistance of pigs to genotype 1 but not genotype 2 porcine reproductive and respiratory syndrome virus

Journal of Virology

Volumn 91, Issue 2, 2017, Pages

  Wells, Kevin D ^a   Bardot, Rachel ^b   Whitworth, Kristin M ^a   Trible, Benjamin R ^b   Fang, Ying ^b   Mileham, Alan ^c   Kerrigan, Maureen A ^b   Samuel, Melissa S ^a   Prather, Randall S ^a   Rowland, Raymond R R ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

^c GENUS PLC   (United States)

Author keywords

CD163; Genetic modification; Porcine reproductive and respiratory syndrome virus

Indexed keywords

CD163 ANTIGEN; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CD163 GENE; CONTROLLED STUDY; GENOTYPE; IMMUNOREACTIVITY; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PIG; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PRIORITY JOURNAL; SEROCONVERSION; STOP CODON; VIRUS REPLICATION; VIRUS RESISTANCE; ANIMAL; CHEMISTRY; DISEASE RESISTANCE; GENE LOCUS; GENE ORDER; GENETIC PREDISPOSITION; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; METABOLISM; MUTATION; PHENOTYPE; PHYSIOLOGY; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PROTEIN DOMAIN; VIROLOGY; VIRUS LOAD;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; DISEASE RESISTANCE; GENE ORDER; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOST-PATHOGEN INTERACTIONS; MACROPHAGES, ALVEOLAR; MUTATION; PHENOTYPE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, CELL SURFACE; SWINE; VIRAL LOAD;

EID: 85008704812     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01521-16     Document Type: Article

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