Brain Serotonin Neurotoxicity and Fenfluramine and Dexfenfluramine-Reply

JAMA: The Journal of the American Medical Association

Volumn 278, Issue 24, 1997, Pages 2142-

  Mccann, Una D ^a   Seiden, Lewis S ^b   Rubin, Lewis J ^c   Ricaurte, George A ^d  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85008566620     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.1997.03550240032024     Document Type: Letter

References (6)

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2. Kleven MS, Schuster CR, Seiden LS. Effect of depletion of brain serotonin by repeated fenfluramine on neurochemical and anorectic effects of acute fenfluramine. J Pharmacol Exp Ther. 1988;246:822-828.
3. O'Callaghan JP, Miller DB. Quantification of reactive gliosis as an approach to neurotoxicity assessment. In: Erinoff L, ed. Assessing Neurotoxicity of Drugs of Abuse. Rockville, Md: National Institute on Drug Abuse; 1993:188-212. NIDA Monograph 136, DHHS publication 93-3644.
4. Rowland NE, Kalehua AN, Li B-H, Semple-Rowland SL, Streit WJ. Loss of serotonin uptake sites and immunoreactivity in rat cortex after dexfenfluramine occur without parallel glial cell reactions. Brain Res. 1993;624:35-43.
5. O'Callaghan JP, Miller DB. Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse. J Pharmacol Exp Ther. 1994;270:741-751.
6. Backmann R, Dengler H, Gahl K, et al. Primaere pulmonale hypertonie. Verh Dtsch Ges Kreislaufforschung. 1972;38:134-141.