Fatal disseminated aspergillus penicillioides infection in a 3-month-old infant with suspected cystic fibrosis: Autopsy case report with review of literature

Pediatric and Developmental Pathology

Volumn 19, Issue 6, 2016, Pages 506-511

  Gupta, Kirti ^a   Gupta, Parikshaa ^a   Mathew, Joseph L ^a   Bansal, Arun ^a   Singh, Gangandeep ^a   Singh, Meenu ^a   Chakrabarti, Arunaloke ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Autopsy; Cystic fibrosis; Disseminated; Invasive aspergillosis

Indexed keywords

AMIKACIN; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; GENTAMICIN; LEVOFLOXACIN; MEROPENEM; MINOCYCLINE; PIPERACILLIN PLUS TAZOBACTAM;

ABNORMAL RESPIRATORY SOUND; ACINAR CELL; ANTIBIOTIC RESISTANCE; AREFLEXIA; ARTICLE; ARTIFICIAL VENTILATION; ASPERGILLUS; ASPERGILLUS PENICILLIOIDES; ATROPHY; AUTOPSY; BILIARY TRACT MALFORMATION; BLOOD CLOTTING DISORDER; BLOOD CULTURE; BRONCHOPNEUMONIA; CALCIFICATION; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CYSTIC FIBROSIS; ENTEROBACTER; FAILURE TO THRIVE; FAMILIAL DISEASE; FATALITY; FATTY LIVER; FUNGUS HYPHAE; FUNGUS IDENTIFICATION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN TISSUE; HYPOPLASIA; HYPOPROTEINEMIA; INFANT; INVASIVE ASPERGILLOSIS; KIDNEY ABSCESS; LEUKOCYTOSIS; LIVER DYSFUNCTION; MALE; METABOLIC ACIDOSIS; MYELOPHTHISIC ANEMIA; NONHUMAN; PANCREAS EXAMINATION; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY DISTRESS; SCLERODERMA; THORAX RADIOGRAPHY; ASPERGILLOSIS; COMPLICATION; MICROBIOLOGY; PATHOLOGY;

ASPERGILLOSIS; ASPERGILLUS; AUTOPSY; CYSTIC FIBROSIS; FATAL OUTCOME; HUMANS; INFANT; MALE;

EID: 85008502130     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/15-10-1729-CR.1     Document Type: Article

References (20)

1. Sheppard MN, Nicholson AG. The pathology of cystic fibrosis. Current Diag Pathol 2002;8:50-59.
2. Chung Y, Kraut JR, Stone AM, Valaitis J. Disseminated aspergillosis in a patient with cystic fibrosis and allergic bronchopulmonary aspergillosis. Pediatr Pulmonol 1994;17:131-134.
3. Bhargava V, Tomashefski JF Jr, Stern RC, Abramowsky CR. The pathology of fungal infection and colonization in patients with cystic fibrosis. Hum Pathol 1989;20:977-986.
4. Guidotti TL, Luetzeler J, di Sant' Agnese PA, Escaro DU. Fatal disseminated aspergillosis in a previously well young adult with cystic fibrosis. Am J Med Sci 1982;283:157-160.
5. Luong ML, Chaparro C, Stephenson A, et al. Pretransplant Aspergillus colonization of cystic fibrosis patients and the incidence of post-lung transplant invasive aspergillosis. Transplantation 2014;97:351-357.
6. Massam J, Bitnun A, Solomon M, et al. Invasive aspergillosis in cystic fibrosis: A fatal case in an adolescent and review of the literature. Pediatr Infect Dis J 2010;30:178-180.
7. Bialek R, Ibricevic A, Aepinus C, et al. Detection of Paracoccidioides brasiliensis in tissue samples by a nested PCR assay. J Clin Microbiol 2000;38:2940-2942.
8. Kabra SK, Kabra M, Lodha R, Shastri S. Cystic fibrosis in India. Pediatr Pulmonol 2007;42:1087-1094.
9. Le Grys VA. Assessment of sweat-testing practices for the diagnosis of cystic fibrosis. Arch Pathol Lab Med. 2001;125:1420-1424.
10. Lipuma JJ. The changing microbial epidemiology in cystic fibrosis. Clin Microbiol Rev 2010;23:299-323.
11. Milla CE, Wielinski CL, Regelmann WE. Clinical significance of the recovery of Aspergillus species from the respiratory secretions of cystic fibrosis patients. Pediatr Pulmonol 1996;21:6-10.
12. Geller DE, Kaplowitz H, Light MJ, Colin AA. Allergic bronchopulmonary aspergillosis in cystic fibrosis: reported prevalence, regional distribution, and patient characteristics. Scientific Advisory Group, Investigators, and Coordinators of the Epidemiologic Study of Cystic Fibrosis. Chest 1999;116:639-646.
13. Mastella G, Rainisio M, Harms HK, et al. Allergic bronchopulmonary aspergillosis in cystic fibrosis. A European epidemiological study. Epidemiologic Registry of Cystic Fibrosis. Eur Respir J 2000;16: 464-471.
14. Maguire CP, Hayes JP, Hayes M, Masterson J, FitzGerald MX. Three cases of pulmonary aspergilloma in adult patients with cystic fibrosis. Thorax 1995;50:805-806.
15. Brown K, Rosenthal M, Bush A. Fatal invasive aspergillosis in an adolescent with cystic fibrosis. Pediatr Pulmonol 1999;27: 130-133.
16. Chow L, Brown NE, Kunimoto D. An unusual case of pulmonary invasive aspergillosis and aspergilloma cured with voriconazole in a patient with cystic fibrosis. Clin Infect Dis 2002;35:e106-e110.
17. Mosquera RA, Estrada L, Clements RM, Jon CK. Early diagnosis and treatment of invasive pulmonary aspergillosis in a patient with cystic fibrosis. BMJ Case Rep 2013;18:2013.
18. Cimon B, Carrère J, Chazalette JP, et al. Fungal colonization and immune response to fungi in cystic fibrosis. J Mycol Med 1995;5: 211-216.
19. Sabino R, Ferreira JA, Moss RB, et al. Molecular epidemiology of Aspergillus collected from cystic fibrosis patients. J Cyst Fibros 2015;14:474-481.
20. Samson RA, van der Lustgraaf B. Aspergillus penicilloides and Eurotium halophilicum in association with house-dust mites. Mycopathologia 1978;64:13-16.