Ultrasound acceleration of rt-PA thrombolysis depends on acoustic intensity

Biological and Pharmaceutical Bulletin

Volumn 40, Issue 1, 2017, Pages 97-103

  Sawaguchi, Yoshikazu ^a   Wang, Zuojun ^b  

^a NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute ischemic stroke (AIS); Noninvasive ultrasound; Sonothrombolysis; Tissue plasminogen activator (t PA)

Indexed keywords

ALTEPLASE; RECOMBINANT PROTEIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ARTICLE; BLOOD CLOT LYSIS; BOVINE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; IN VITRO STUDY; INTERVENTIONAL ULTRASONOGRAPHY; NONHUMAN; SOUND INTENSITY; ANIMAL; THROMBOSIS; ULTRASOUND; ULTRASOUND THERAPY;

ANIMALS; CATTLE; RECOMBINANT PROTEINS; THROMBOSIS; TISSUE PLASMINOGEN ACTIVATOR; ULTRASONIC THERAPY; ULTRASONIC WAVES;

EID: 85008430090     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b16-00702     Document Type: Article

References (27)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med., 333, 1581-1588 (1995).
2. Yamaguchi T, Mori E, Minematsu K, Nakagawara J, Hashi K, Saito I, Shinohara Y, Japan Alteplase Clinical Trial (J-ACT) Group. Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT). Stroke, 37, 1810-1815 (2006).
3. Graham GD. Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data. Stroke, 34, 2847-2850 (2003).
4. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S, Investigators AT, Investigators ETATLANTIS Trials Investigators ECASS Trials Investigators NINDS rt-PA Study Group Investigators. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet, 363, 768-774 (2004).
5. Molina CA, Ribo M, Rubiera M, Montaner J, Santamarina E, Delgado-Mederos R, Arenillas JF, Huertas R, Purroy F, Delgado P, Alvarez-Sabin J. Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator. Stroke, 37, 425-429 (2006).
6. Tsivgoulis G, Eggers J, Ribo M, Perren F, Saqqur M, Rubiera M, Sergentanis TN, Vadikolias K, Larrue V, Molina CA, Alexandrov AV. Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies. Stroke, 41, 280-287 (2010).
7. Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, Kaste M, Lipka LJ, Pedraza S, Ringleb PA, Rowley HA, Schneider D, Schwamm LH, Leal JS, Sohngen M, Teal PA, Wilhelm-Ogunbiyi K, Wintermark M, Warach S. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol., 8, 141-150 (2009).
8. Parsons M, Spratt N, Bivard A, Campbell B, Chung K, Miteff F, O'Brien B, Bladin C, McElduff P, Allen C, Bateman G, Donnan G, Davis S, Levi C. Arandomized trial of tenecteplase versus alteplase for acute ischemic stroke. N. Engl. J. Med., 366, 1099-1107 (2012).
9. Eggers J, Konig IR, Koch B, Handler G, Seidel G. Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebral artery main stem occlusion: results from a randomized study. Stroke, 39, 1470-1475 (2008).
10. Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis- associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke, 33, 831-836 (2002).
11. Copin JC, Merlani P, Sugawara T, Chan PH, Gasche Y. Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats. Exp. Neurol., 213, 196-201 (2008).
12. Gore JM, Sloan M, Price TR, Randall AM, Bovill E, Collen D, Forman S, Knatterud GL, Sopko G, Terrin ML. Intracerebral hemorrhage, cerebral infarction, and subdural hematoma after acute myocardial infarction and thrombolytic therapy in the Thrombolysis in Myocardial Infarction Study. Thrombolysis in Myocardial Infarction, Phase II, pilot and clinical trial. Circulation, 83, 448-459 (1991).
13. Cannon CP, Gibson CM, McCabe CH, Adgey AA, Schweiger MJ, Sequeira RF, Grollier G, Giugliano RP, Frey M, Mueller HS, Steingart RM, Weaver WD, Van de Werf F, Braunwald E. TNK-tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction: results of the TIMI 10B trial. Thrombolysis in Myocardial Infarction (TIMI) 10B Investigators. Circulation, 98, 2805-2814 (1998).
14. Itoh T, Matsumoto M, Handa N, Maeda H, Hougaku H, Hashimoto H, Etani H, Tsukamoto Y, Kamada T. Rate of successful recording of blood flow signals in the middle cerebral artery using transcranial Doppler sonography. Stroke, 24, 1192-1195 (1993).
15. Hashimoto H, Etani H, Naka M, Kinoshita N, Nukada T. [Assessment of the rate of successful transcranial Doppler recording through the temporal windows in Japanese with special reference to aging and sex]. Nippon Ronen Igakkai Zasshi, 29, 119-122 (1992).
16. Caplan LR, Brass LM, DeWitt LD, Adams RJ, Gomez C, Otis S, Weschler LR, von Reutern GM. Transcranial Doppler ultrasound: present status. Neurology, 40, 696-700 (1990).
17. Ishibashi T, Akiyama M, Onoue H, Abe T, Furuhata H. Can transcranial ultrasonication increase recanalization flow with tissue plasminogen activator? Stroke, 33, 1399-1404 (2002).
18. Saguchi T, Onoue H, Urashima M, Ishibashi T, Abe T, Furuhata H. Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke model. Stroke, 39, 1007-1011 (2008).
19. Azuma T, Kawabata K, Umemura S, Ogihara M, Kubota J, Sasaki A, Furuhata H. Bubble generation by standing wave in water surrounded by cranium with transcranial ultrasonic beam. Jpn. J. Appl. Phys., 44 (6B), 4625-4630 (2005).
20. Sawaguchi Y., Wang Z., Furuhata H., Ultrasound control of the growth of thrombus Potential for the embolus growth suppression & the reocclusion prevention. Japanese Journal of Medical Ultrasonics, 38, 549-555 (2011).
21. Apfel RE, Holland CK. Gauging the likelihood of cavitation from short-pulse, low-duty cycle diagnostic ultrasound. Ultrasound Med. Biol., 17, 179-185 (1991).
22. Suzuki Y. Role of tissue-type plasminogen activator in ischemic stroke. J. Pharmacol. Sci., 113, 203-207 (2010).
23. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, Larrue V, Bluhmki E, Davis S, Donnan G, Schneider D, Diez-Tejedor E, Trouillas P, Second European-Australasian Acute Stroke Study Investigators. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet, 352, 1245-1251 (1998).
24. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D, ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N. Engl. J. Med., 359, 1317-1329 (2008).
25. Alexandrov AV, Molina CA, Grotta JC, Garami Z, Ford SR, Alvarez-Sabin J, Montaner J, Saqqur M, Demchuk AM, Moye LA, Hill MD, Wojner AW, CLOTBUST Investigators. Ultrasoundenhanced systemic thrombolysis for acute ischemic stroke. N. Engl. J. Med., 351, 2170-2178 (2004).
26. Daffertshofer M, Gass A, Ringleb P, Sitzer M, Sliwka U, Els T, Sedlaczek O, Koroshetz WJ, Hennerici MG. Transcranial lowfrequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial. Stroke, 36, 1441-1446 (2005).
27. Furuhata H, Saito O. Comparative study of standing wave reduction methods using random modulation for transcranial ultrasonication. Ultrasound Med. Biol., 39, 1440-1450 (2013).