Speed Limits for Nonvesicular Intracellular Sterol Transport

Trends in Biochemical Sciences

Volumn 42, Issue 2, 2017, Pages 90-97

  Dittman, Jeremy S ^a   Menon, Anant K ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

diffusion; endoplasmic reticulum; membrane contact site; Osh4; StARD4; sterol transport protein

Indexed keywords

CARRIER PROTEIN; ERGOSTEROL; STEROL; STEROL TRANSPORT PROTEIN; UNCLASSIFIED DRUG;

CELL MEMBRANE; CYTOARCHITECTURE; CYTOPLASM; DESORPTION; DIFFUSION; ENDOPLASMIC RETICULUM; INTRACELLULAR TRANSPORT; LIPID TRANSPORT; NONHUMAN; PROTEIN FUNCTION; REVIEW; SACCHAROMYCES CEREVISIAE; STEROL ANALYSIS; STEROL SYNTHESIS; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS; ANIMAL; HUMAN; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; ENDOPLASMIC RETICULUM; HUMANS; STEROLS;

EID: 85008224748     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2016.11.004     Document Type: Review

References (31)

1. 1 Maxfield, F.R., van Meer, G., Cholesterol, the central lipid of mammalian cells. Curr. Opin. Cell. Biol. 22 (2010), 422–429.
2. 2 Holthuis, J.C., Menon, A.K., Lipid landscapes and pipelines in membrane homeostasis. Nature 510 (2014), 48–57.
3. 3 Mesmin, B., Maxfield, F.R., Intracellular sterol dynamics. Biochim. Biophys. Acta 1791 (2009), 636–645.
4. 4 Brown, M.S., Goldstein, J.L., Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J. Lipid Res. 50:Suppl (2009), S15–S27.
5. 5 Brown, M.S., Goldstein, J.L., A century of cholesterol and coronaries: from plaques to genes to statins. Cell 161 (2015), 161–172.
6. 6 Wüstner, D., Solanko, K., How cholesterol interacts with proteins and lipids during its intracellular transport. Biochim. Biophys. Acta 1848 (2015), 12–28.
7. 7 Urbani, L., Simoni, R.D., Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane. J. Biol. Chem. 265 (1990), 1919–1923.
8. 8 Heino, S., et al. Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. Proc. Natl. Acad. Sci. U.S.A. 97 (2000), 8375–8380.
9. 9 Li, Y., Prinz, W.A., ATP-binding cassette (ABC) transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the endoplasmic reticulum. J. Biol. Chem. 279 (2004), 45226–45234.
10. 10 Baumann, N.A., et al. Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration. Biochemistry 44 (2005), 5816–5826.
11. 11 Pichler, H., et al. A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids. Eur. J. Biochem. 268 (2001), 2351–2361.
12. 12 West, M., et al. A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. J. Cell. Biol. 193 (2011), 333–346.
13. 13 Lahiri, S., et al. Membrane contact sites, gateways for lipid homeostasis. Curr. Opin. Cell Biol. 33 (2015), 82–87.
14. 14 Sullivan, D.P., et al. Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast. Biochem. Soc. Trans. 34 (2006), 356–358.
15. 15 Georgiev, A.G., et al. Osh proteins regulate membrane sterol organization but are not required for sterol movement between the ER and PM. Traffic 12 (2011), 1341–1355.
16. 16 McLean, L.R., Phillips, M.C., Mechanism of cholesterol and phosphatidylcholine exchange or transfer between unilamellar vesicles. Biochemistry 20 (1981), 2893–2900.
17. 17 Phillips, M.C., et al. Mechanisms and consequences of cellular cholesterol exchange and transfer. Biochimica et Biophysica Acta 906 (1987), 223–276.
18. 18 Berg, H.C., Random Walks in Biology. 1983, Princeton University Press.
19. 19 Di Rienzo, C., et al. Probing short-range protein Brownian motion in the cytoplasm of living cells. Nat. Commun., 5, 2014, 5891.
20. 20 Evans, E., Probing the relation between force–lifetime–and chemistry in single molecular bonds. Annu. Rev. Biophys. Biomol. Struct. 30 (2001), 105–128.
21. 21 Daune, M., Molecular Biophysics: Structures in Motion. 1999, Oxford University Press.
22. 22 Iaea, D.B., et al. STARD4 membrane interactions and sterol binding. Biochemistry 54 (2015), 4623–4636.
23. 23 von Filseck, J.M., et al. A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes. Nat. Commun., 6, 2015, 6671.
24. 24 Ghaemmaghami, S., et al. Global analysis of protein expression in yeast. Nature 425 (2003), 737–741.
25. 25 Kulak, N.A., et al. Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells. Nat. Methods 11 (2014), 319–324.
26. 26 Stefan, C.J., et al. Osh proteins regulate phosphoinositide metabolism at ER–plasma membrane contact sites. Cell 144 (2011), 389–401.
27. 27 Tavassoli, S., et al. Plasma membrane–endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis. EMBO Rep. 14 (2013), 434–440.
28. 28 Gatta, A.T., et al. A new family of StART domain proteins at membrane contact sites has a role in ER–PM sterol transport. Elife, 2015, 4.
29. 29 Saheki, Y., et al. Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nature Cell Biology 18 (2016), 504–515.
30. 30 de Saint-Jean, M., et al. Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J. Cell Biol. 195 (2011), 965–978.
31. 31 Raychaudhuri, S., et al. Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J. Cell Biol. 173 (2006), 107–119.