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Volumn 77, Issue 12, 2016, Pages e1639-e1646

Targeting treatments to improve cognitive function in mood disorder: Suggestions from trials using erythropoietin

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; RECOMBINANT ERYTHROPOIETIN; ERYTHROPOIETIN;

EID: 85007609246     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.15m10480     Document Type: Article
Times cited : (26)

References (47)
  • 1
    • 84883347388 scopus 로고    scopus 로고
    • Cognitive impairment in euthymic major depressive disorder: A meta-Analysis
    • Bora E, Harrison BJ, Y el M, et al. Cognitive impairment in euthymic major depressive disorder: A meta-Analysis. Psychol Med. 2013;43(10):2017-2026. doi:10.1017/S0329171202085
    • (2013) Psychol Med , vol.43 , Issue.10 , pp. 2017-2026
    • Bora, E.1    Harrison, B.J.2    El, M.Y.3
  • 2
    • 70249100595 scopus 로고    scopus 로고
    • A meta-Analytic investigation of neurocognitive deficits in bipolar illness: Profile and effects of clinical state
    • Kurtz MM, Gerraty RT. A meta-Analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology. 2009;23(5):551-562. doi:10.1037/a01627
    • (2009) Neuropsychology , vol.23 , Issue.5 , pp. 551-562
    • Kurtz, M.M.1    Gerraty, R.T.2
  • 3
    • 84860385632 scopus 로고    scopus 로고
    • Meta-Analysis of the association between cognitive abilities and everyday functioning in bipolar disorder
    • Depp CA, Mausbach BT, Harmell AL, et al. Meta-Analysis of the association between cognitive abilities and everyday functioning in bipolar disorder. Bipolar Disord. 2012;14(3):217-226. doi:10.1/j.139-5618.2012.0101.x
    • (2012) Bipolar Disord , vol.14 , Issue.3 , pp. 217-226
    • Depp, C.A.1    Mausbach, B.T.2    Harmell, A.L.3
  • 4
    • 33750690680 scopus 로고    scopus 로고
    • Neurocognitive deficits and disability in major depressive disorder
    • Jaeger J, Berns S, Uzelac S, et al. Neurocognitive deficits and disability in major depressive disorder. Psychiatry Res. 2006;145(1):39-48. doi:10.1016/j.psychres.205.1.01
    • (2006) Psychiatry Res , vol.145 , Issue.1 , pp. 39-48
    • Jaeger, J.1    Berns, S.2    Uzelac, S.3
  • 5
    • 84867455604 scopus 로고    scopus 로고
    • Pharmacological approaches in bipolar disorders and the impact on cognition: A critical overview
    • Dias VV, Balanz Martinez V, Soeiro-de-Souza MG, et al. Pharmacological approaches in bipolar disorders and the impact on cognition: A critical overview. Acta Psychiatr Scand. 2012;126(5):315-331. doi:10.1/j.160-047.2012.01910.x
    • (2012) Acta Psychiatr Scand , vol.126 , Issue.5 , pp. 315-331
    • Dias, V.V.1    Balanz Martinez, V.2    Soeiro-De-Souza, M.G.3
  • 6
    • 84924088127 scopus 로고    scopus 로고
    • Cognitive dysfunction in depression-pathophysiology and novel targets
    • Carvalho AF, Miskowiak KK, Hyphantis TN, et al. Cognitive dysfunction in depression-pathophysiology and novel targets. CNS Neurol Disord Drug Targets. 2014;13(10):1819-1835. doi:10.2174/1871527313614130203627
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , Issue.10 , pp. 1819-1835
    • Carvalho, A.F.1    Miskowiak, K.K.2    Hyphantis, T.N.3
  • 7
    • 84935483167 scopus 로고    scopus 로고
    • Effects of short-Term cognitive remediation on cognitive dysfunction in partially or fully remitted individuals with bipolar disorder: Results of a randomised controlled trial
    • Demant KM, Vinberg M, Kessing LV, et al. Effects of short-Term cognitive remediation on cognitive dysfunction in partially or fully remitted individuals with bipolar disorder: results of a randomised controlled trial. PLoS One. 2015;10(6):e0127955. doi:10.1371/journal.pone.012795
    • (2015) PLoS One , vol.10 , Issue.6 , pp. e0127955
    • Demant, K.M.1    Vinberg, M.2    Kessing, L.V.3
  • 8
    • 84889053085 scopus 로고    scopus 로고
    • Cognitive remediation as a treatment for major depression: A rationale, review of evidence and recommendations for future research
    • Porter RJ, Bowie CR, Jordan J, et al. Cognitive remediation as a treatment for major depression: A rationale, review of evidence and recommendations for future research. Aust N Z J Psychiatry. 2013;47(12):1165-1175. doi:10.17/04867413502090
    • (2013) Aust N Z J Psychiatry , vol.47 , Issue.12 , pp. 1165-1175
    • Porter, R.J.1    Bowie, C.R.2    Jordan, J.3
  • 9
    • 84929597055 scopus 로고    scopus 로고
    • Cognition as a target in major depression: New developments
    • Sol B, Jimez E, Martinez-Aran A, et al. Cognition as a target in major depression: new developments. Eur Neuropsychopharmacol. 2015;25(2):231-247. doi:10.1016/j.euroneuro.2014.12.04
    • (2015) Eur Neuropsychopharmacol , vol.25 , Issue.2 , pp. 231-247
    • Sol, B.1    Jimez, E.2    Martinez-Aran, A.3
  • 10
    • 84884148956 scopus 로고    scopus 로고
    • The global cognitive impairment in schizophrenia: Consistent over decades and around the world
    • Schaefer J, Giangrande E, Weinberger DR, et al. The global cognitive impairment in schizophrenia: consistent over decades and around the world. Schizophr Res. 2013;150(1):42-50. doi:10.1016/j.schres.2013.07.09
    • (2013) Schizophr Res , vol.150 , Issue.1 , pp. 42-50
    • Schaefer, J.1    Giangrande, E.2    Weinberger, D.R.3
  • 11
    • 69249086858 scopus 로고    scopus 로고
    • Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders
    • Reichenberg A, Harvey PD, Bowie CR, et al. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull. 2009;35(5):1022-1029. doi:10.1093/schbul/sbn04
    • (2009) Schizophr Bull , vol.35 , Issue.5 , pp. 1022-1029
    • Reichenberg, A.1    Harvey, P.D.2    Bowie, C.R.3
  • 12
    • 33646007355 scopus 로고    scopus 로고
    • Neuropsychological test profiles in schizophrenia and non-psychotic depression
    • Rund BR, Sundet K, Asbjnsen A, et al. Neuropsychological test profiles in schizophrenia and non-psychotic depression. Acta Psychiatr Scand. 2006;113(4):350-359. doi:10.1/j.160-047.205.0626.x
    • (2006) Acta Psychiatr Scand , vol.113 , Issue.4 , pp. 350-359
    • Rund, B.R.1    Sundet, K.2    Asbjnsen, A.3
  • 13
    • 47749154418 scopus 로고    scopus 로고
    • The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: An unaccounted source of variance in clinical trials
    • Gualtieri CT, Morgan DW. The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: An unaccounted source of variance in clinical trials. J Clin Psychiatry. 2008;69(7):1122-1130. doi:10.4088/JCP.v69n0712
    • (2008) J Clin Psychiatry , vol.69 , Issue.7 , pp. 1122-1130
    • Gualtieri, C.T.1    Morgan, D.W.2
  • 14
    • 84939465886 scopus 로고    scopus 로고
    • Assessment of subjective and objective cognitive function in bipolar disorder: Correlations, predictors and the relation to psychosocial function
    • Demant KM, Vinberg M, Kessing LV, et al. Assessment of subjective and objective cognitive function in bipolar disorder: Correlations, predictors and the relation to psychosocial function. Psychiatry Res. 2015;229(1-2):565-571. doi:10.1016/j.psychres.2015.05.02
    • (2015) Psychiatry Res , vol.229 , Issue.1-2 , pp. 565-571
    • Demant, K.M.1    Vinberg, M.2    Kessing, L.V.3
  • 15
    • 84939806918 scopus 로고    scopus 로고
    • Optimising screening for cognitive dysfunction in bipolar disorder: Validation and evaluation of objective and subjective tools
    • Jensen JH, Sttrup MM, Nayberg E, et al. Optimising screening for cognitive dysfunction in bipolar disorder: validation and evaluation of objective and subjective tools. J Affect Disord. 2015;187(10):10-19. doi:10.1016/j.jad.2015.07.039
    • (2015) J Affect Disord , vol.187 , Issue.10 , pp. 10-19
    • Jensen, J.H.1    Sttrup, M.M.2    Nayberg, E.3
  • 16
    • 84946725072 scopus 로고    scopus 로고
    • Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools
    • Ott CV, Bjertrup AJ, Jensen JH, et al. Screening for cognitive dysfunction in unipolar depression: validation and evaluation of objective and subjective tools. J Affect Disord. 2016;190:607-615. doi:10.1016/j.jad.2015.10.059
    • (2016) J Affect Disord , vol.190 , pp. 607-615
    • Ott, C.V.1    Bjertrup, A.J.2    Jensen, J.H.3
  • 17
    • 84856302962 scopus 로고    scopus 로고
    • Placebocontrolled adjunctive trial of pramipexole in patients with bipolar disorder: Targeting cognitive dysfunction
    • Burdick KE, Braga RJ, Nnadi CU, et al. Placebocontrolled adjunctive trial of pramipexole in patients with bipolar disorder: Targeting cognitive dysfunction. J Clin Psychiatry. 2012;73(1):103-112. doi:10.4088/JCP.11m07299
    • (2012) J Clin Psychiatry , vol.73 , Issue.1 , pp. 103-112
    • Burdick, K.E.1    Braga, R.J.2    Nnadi, C.U.3
  • 18
    • 84877715879 scopus 로고    scopus 로고
    • Efficacy of functional remediation in bipolar disorder: A multicenter randomized controlled study
    • Torrent C, Bonnin CdelM, Martez-Ar A, et al. Efficacy of functional remediation in bipolar disorder: A multicenter randomized controlled study. Am J Psychiatry. 2013;170(8):852-859. doi:10.176/api.ajp.2012.12070971
    • (2013) Am J Psychiatry , vol.170 , Issue.8 , pp. 852-859
    • Torrent, C.1    Bonnin Cdel, M.2    Martez-Ar, A.3
  • 19
    • 84975886202 scopus 로고    scopus 로고
    • Effects of functional remediation on neurocognitively impaired bipolar patients: Enhancement of verbal memory
    • CIBERSAM Functional Remediation Group
    • Bonnin CM, Reinares M, Martez-Ar A, et al; CIBERSAM Functional Remediation Group. Effects of functional remediation on neurocognitively impaired bipolar patients: enhancement of verbal memory. Psychol Med. 2016;46(2):291-301. doi:10.1017/S0329171501713
    • (2016) Psychol Med , vol.46 , Issue.2 , pp. 291-301
    • Bonnin, C.M.1    Reinares, M.2    Martez-Ar, A.3
  • 20
    • 70449396453 scopus 로고    scopus 로고
    • Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: A proof-ofconcept study
    • Iosifescu DV, Moore CM, Deckersbach T, et al. Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: A proof-ofconcept study. CNS Neurosci Ther. 2009;15(4):309-319. doi:10.1/j.175-5949.209.090.x
    • (2009) CNS Neurosci Ther , vol.15 , Issue.4 , pp. 309-319
    • Iosifescu, D.V.1    Moore, C.M.2    Deckersbach, T.3
  • 21
    • 84924810039 scopus 로고    scopus 로고
    • Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: A double-blind, randomized, placebo-controlled phase 2 trial
    • Miskowiak KW, Ehrenreich H, Christensen EM, et al. Recombinant human erythropoietin to target cognitive dysfunction in bipolar disorder: A double-blind, randomized, placebo-controlled phase 2 trial. J Clin Psychiatry. 2014;75(12):1347-1355. doi:10.4088/JCP.13m08839
    • (2014) J Clin Psychiatry , vol.75 , Issue.12 , pp. 1347-1355
    • Miskowiak, K.W.1    Ehrenreich, H.2    Christensen, E.M.3
  • 22
    • 84865841613 scopus 로고    scopus 로고
    • Is there an association between subjective and objective measures of cognitive function in patients with affective disorders?
    • Svendsen AM, Kessing LV, Munkholm K, et al. Is there an association between subjective and objective measures of cognitive function in patients with affective disorders? Nord J Psychiatry. 2012;66(4):248-253. doi:10.3109/0803948.201.626870
    • (2012) Nord J Psychiatry , vol.66 , Issue.4 , pp. 248-253
    • Svendsen, A.M.1    Kessing, L.V.2    Munkholm, K.3
  • 23
    • 84900829352 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for treating treatment-resistant depression: A double-blind, randomized, placebo-controlled phase 2 trial
    • Miskowiak KW, Vinberg M, Christensen EM, et al. Recombinant human erythropoietin for treating treatment-resistant depression: A double-blind, randomized, placebo-controlled phase 2 trial. Neuropsychopharmacology. 2014;39(6):1399-1408. doi:10.1038/np.2013.35
    • (2014) Neuropsychopharmacology , vol.39 , Issue.6 , pp. 1399-1408
    • Miskowiak, K.W.1    Vinberg, M.2    Christensen, E.M.3
  • 24
    • 84937546189 scopus 로고    scopus 로고
    • Effects of erythropoietin on hippocampal volume and memory in mood disorders
    • Miskowiak KW, Vinberg M, Macoveanu J, et al. Effects of erythropoietin on hippocampal volume and memory in mood disorders. Biol Psychiatry. 2015;78(4):270-277. doi:10.1016/j.biopsych.2014.12.013
    • (2015) Biol Psychiatry , vol.78 , Issue.4 , pp. 270-277
    • Miskowiak, K.W.1    Vinberg, M.2    Macoveanu, J.3
  • 25
    • 84873313538 scopus 로고    scopus 로고
    • Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia
    • Ktner A, Grube S, El-Kordi A, et al. Common variants of the genes encoding erythropoietin and its receptor modulate cognitive performance in schizophrenia. Mol Med. 2012;18:1029-1040. doi:10.219/molmed.2012.0190
    • (2012) Mol Med , vol.18 , pp. 1029-1040
    • Ktner, A.1    Grube, S.2    El-Kordi, A.3
  • 26
    • 84856672725 scopus 로고    scopus 로고
    • Erythropoietin: A candidate treatment for mood symptoms and memory dysfunction in depression
    • Miskowiak KW, Vinberg M, Harmer CJ, et al. Erythropoietin: A candidate treatment for mood symptoms and memory dysfunction in depression. Psychopharmacology (Berl). 2012;219(3):687-698. doi:10.107/s0213-01-251-1
    • (2012) Psychopharmacology (Berl , vol.219 , Issue.3 , pp. 687-698
    • Miskowiak, K.W.1    Vinberg, M.2    Harmer, C.J.3
  • 27
    • 78649668528 scopus 로고    scopus 로고
    • Erythropoietin as neuroprotective and neuroregenerative treatment strategy: Comprehensive overview of 12 years of preclinical and clinical research
    • Sargin D, Friedrichs H, El-Kordi A, et al. Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research. Best Pract Res Clin Anaesthesiol. 2010;24(4):573-594. doi:10.1016/j.bpa.2010.10.05
    • (2010) Best Pract Res Clin Anaesthesiol , vol.24 , Issue.4 , pp. 573-594
    • Sargin, D.1    Friedrichs, H.2    El-Kordi, A.3
  • 28
    • 77957725156 scopus 로고    scopus 로고
    • Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder
    • Miskowiak KW, Vinberg M, Harmer CJ, et al. Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder. Trials. 2010;11:97. doi:10.186/1745-6215-1-97
    • (2010) Trials , vol.11 , pp. 97
    • Miskowiak, K.W.1    Vinberg, M.2    Harmer, C.J.3
  • 29
    • 1342325375 scopus 로고    scopus 로고
    • Assessing past treatment history: Test-retest reliability of the Treatment Response to Antidepressant Questionnaire
    • Posternak MA, Young D, Sheeran T, et al. Assessing past treatment history: Test-retest reliability of the Treatment Response to Antidepressant Questionnaire. J Nerv Ment Dis. 2004;192(2):95-102. doi:10.1097/01.nmd.010280.19284.47
    • (2004) J Nerv Ment Dis , vol.192 , Issue.2 , pp. 95-102
    • Posternak, M.A.1    Young, D.2    Sheeran, T.3
  • 30
    • 72949151592 scopus 로고
    • A rating scale for depression
    • Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62. doi:10.136/jnp.23.1.56
    • (1960) J Neurol Neurosurg Psychiatry , vol.23 , pp. 56-62
    • Hamilton, M.1
  • 31
    • 0018175277 scopus 로고
    • A rating scale for mania: Reliability, validity and sensitivity
    • Young RC, Biggs JT, Ziegler VE, et al. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429-435. doi:10.192/bjp.13.5.429
    • (1978) Br J Psychiatry , vol.133 , pp. 429-435
    • Young, R.C.1    Biggs, J.T.2    Ziegler, V.E.3
  • 32
    • 59749089301 scopus 로고    scopus 로고
    • Reliability and validity of the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire
    • Fava M, Iosifescu DV, Pedrelli P, et al. Reliability and validity of the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire. Psychother Psychosom. 2009;78(2):91-97. doi:10.159/0201934
    • (2009) Psychother Psychosom , vol.78 , Issue.2 , pp. 91-97
    • Fava, M.1    Iosifescu, D.V.2    Pedrelli, P.3
  • 33
    • 0034641710 scopus 로고    scopus 로고
    • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    • Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A. 2000;97(19):10526-10531. doi:10.1073/pnas.97.19.10526
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.19 , pp. 10526-10531
    • Brines, M.L.1    Ghezzi, P.2    Keenan, S.3
  • 34
    • 0842329753 scopus 로고    scopus 로고
    • Erythropoietin: A candidate compound for neuroprotection in schizophrenia
    • Ehrenreich H, Degner D, Meller J, et al. Erythropoietin: A candidate compound for neuroprotection in schizophrenia. Mol Psychiatry. 2004;9(1):42-54.
    • (2004) Mol Psychiatry , vol.9 , Issue.1 , pp. 42-54
    • Ehrenreich, H.1    Degner, D.2    Meller, J.3
  • 35
    • 33846550774 scopus 로고    scopus 로고
    • Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin
    • Ehrenreich H, Hinze-Selch D, Stawicki S, et al. Improvement of cognitive functions in chronic schizophrenic patients by recombinant human erythropoietin. Mol Psychiatry. 2007;12(2):206-220. doi:10.1038/sj.mp.401907
    • (2007) Mol Psychiatry , vol.12 , Issue.2 , pp. 206-220
    • Ehrenreich, H.1    Hinze-Selch, D.2    Stawicki, S.3
  • 36
    • 34848841517 scopus 로고    scopus 로고
    • Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis
    • Ehrenreich H, Fischer B, Norra C, et al. Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis. Brain. 2007;130(pt 10):2577-2588. doi:10.1093/brain/awm203
    • (2007) Brain , vol.130 , pp. 2577-2588
    • Ehrenreich, H.1    Fischer, B.2    Norra, C.3
  • 38
    • 70350654728 scopus 로고
    • An inventory for measuring depression
    • Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-571. doi:10.101/archpsyc.1961.017101203104
    • (1961) Arch Gen Psychiatry , vol.4 , pp. 561-571
    • Beck, A.T.1    Ward, C.H.2    Mendelson, M.3
  • 41
    • 0023710206 scopus 로고
    • Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach
    • DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. Biometrics. 1988;44(3):837-845. doi:10.2307/2531595
    • (1988) Biometrics , vol.44 , Issue.3 , pp. 837-845
    • DeLong, E.R.1    DeLong, D.M.2    Clarke-Pearson, D.L.3
  • 42
    • 85007526122 scopus 로고    scopus 로고
    • R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing
    • R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2011.
    • (2011)
  • 43
    • 84930065118 scopus 로고    scopus 로고
    • The influence of cognitive reserve on psychosocial and neuropsychological functioning in bipolar disorder
    • Forcada I, Mur M, Mora E, et al. The influence of cognitive reserve on psychosocial and neuropsychological functioning in bipolar disorder. Eur Neuropsychopharmacol. 2015;25(2):214-222. doi:10.1016/j.euroneuro.2014.07.018
    • (2015) Eur Neuropsychopharmacol , vol.25 , Issue.2 , pp. 214-222
    • Forcada, I.1    Mur, M.2    Mora, E.3
  • 45
    • 84942046594 scopus 로고    scopus 로고
    • Bipolar disorder
    • Grande I, Berk M, Birmaher B, et al. Bipolar disorder. Lancet. 2016;387(10027):1561-1572. doi:10.1016/S0140-6736(15)0241-X
    • (2016) Lancet , vol.387 , pp. 1561-1572
    • Grande, I.1    Berk, M.2    Birmaher, B.3
  • 46
    • 72649103782 scopus 로고    scopus 로고
    • Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: A long-Term, follow-up study
    • Bonn CM, Martez-Ar A, Torrent C, et al. Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: A long-Term, follow-up study. J Affect Disord. 2010;121(1-2):156-160. doi:10.1016/j.jad.209.05.014
    • (2010) J Affect Disord , vol.121 , Issue.1-2 , pp. 156-160
    • Bonn, C.M.1    Martez-Ar, A.2    Torrent, C.3
  • 47
    • 34247597344 scopus 로고    scopus 로고
    • Functional outcome in bipolar disorder: The role of clinical and cognitive factors
    • Martinez-Aran A, Vieta E, Torrent C, et al. Functional outcome in bipolar disorder: The role of clinical and cognitive factors. Bipolar Disord. 2007;9(1-2):103-113.
    • (2007) Bipolar Disord , vol.9 , Issue.1-2 , pp. 103-113
    • Martinez-Aran, A.1    Vieta, E.2    Torrent, C.3


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