Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

Biomedicine and Pharmacotherapy

Volumn 87, Issue , 2017, Pages 188-195

  Nicolau, Lucas A D ^a   Carvalho, Nathalia S ^b   Pacífico, Dvison M ^a   Lucetti, Larisse T ^a   Aragão, Karoline S ^a   Véras, Leiz M C ^b   Souza, Marcellus H L P ^a   Leite, José R S A ^b   Medeiros, Jand Venes R ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

Author keywords

Epiisopiloturine; Gastrointestinal; Naproxen; Rat

Indexed keywords

ALKALOID; CARBOXYMETHYLCELLULOSE; CYTOKINE; EPIISOPILOTURINE HYDROCHLORIDE; GLUTATHIONE; HISTAMINE; IMIDAZOLE; MALONALDEHYDE; MYELOPEROXIDASE; NAPROXEN; OMEPRAZOLE; RANITIDINE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; EPIISOPILOTURINE; GAMMA BUTYROLACTONE; IMIDAZOLE DERIVATIVE; PLANT EXTRACT; PROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; INTESTINE INJURY; MALE; MUSCLE BLOOD FLOW; NONHUMAN; OXIDATIVE STRESS; PILOCARPUS; PILOCARPUS MICROPHYLLUS; PLANT LEAF; PRIORITY JOURNAL; RAT; SCORING SYSTEM; STOMACH INJURY; STOMACH LESION; STOMACH MUSCLE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; GASTROINTESTINAL DISEASES; INTESTINE MUCOSA; ISOLATION AND PURIFICATION; PATHOLOGY; STOMACH MUCOSA; WISTAR RAT;

4-BUTYROLACTONE; ALKALOIDS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; IMIDAZOLES; INTESTINAL MUCOSA; MALE; NAPROXEN; PILOCARPUS; PLANT EXTRACTS; PLANT LEAVES; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 85007566162     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.12.101     Document Type: Article

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