-
1
-
-
84860120032
-
Why do phase III clinical trials in oncology fail so often?
-
1 Amiri-Kordestani, L, Fojo, T, Why do phase III clinical trials in oncology fail so often?. J Natl Cancer Inst 104 (2012), 568–569.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 568-569
-
-
Amiri-Kordestani, L.1
Fojo, T.2
-
2
-
-
84927126291
-
Overall response rate, progression-free survival, and overall survival with targeted and standard therapies in advanced non-small-cell lung cancer: US Food and Drug Administration trial-level and patient-level analyses
-
2 Blumenthal, GM, Karuri, SW, Zhang, H, et al. Overall response rate, progression-free survival, and overall survival with targeted and standard therapies in advanced non-small-cell lung cancer: US Food and Drug Administration trial-level and patient-level analyses. J Clin Oncol 33 (2015), 1008–1014.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1008-1014
-
-
Blumenthal, G.M.1
Karuri, S.W.2
Zhang, H.3
-
3
-
-
84897018646
-
Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer
-
3 Michaelson, MD, Oudard, S, Ou, YC, et al. Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer. J Clin Oncol 32 (2014), 76–82.
-
(2014)
J Clin Oncol
, vol.32
, pp. 76-82
-
-
Michaelson, M.D.1
Oudard, S.2
Ou, Y.C.3
-
4
-
-
84872078210
-
Abiraterone and increased survival in metastatic prostate cancer
-
4 Ryan, CJ, Smith, MR, de Bono, JS, et al., for the COU-AA-302 Investigators. Abiraterone and increased survival in metastatic prostate cancer. N Engl J Med 368 (2013), 138–148.
-
(2013)
N Engl J Med
, vol.368
, pp. 138-148
-
-
Ryan, C.J.1
Smith, M.R.2
de Bono, J.S.3
-
5
-
-
77957682309
-
Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial
-
5 de Bono, JS, Oudard, S, Ozguroglu, M, et al., for the TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet 376 (2010), 1147–1154.
-
(2010)
Lancet
, vol.376
, pp. 1147-1154
-
-
de Bono, J.S.1
Oudard, S.2
Ozguroglu, M.3
-
6
-
-
4744366279
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
-
6 Tannock, IF, de Wit, R, Berry, WR, et al., for the TAX 327 Investigators. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 351 (2004), 1502–1512.
-
(2004)
N Engl J Med
, vol.351
, pp. 1502-1512
-
-
Tannock, I.F.1
de Wit, R.2
Berry, W.R.3
-
7
-
-
83255176682
-
Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer
-
7 Fizazi, K, De Bono, JS, Flechon, A, et al. Randomised phase II study of siltuximab (CNTO 328), an anti-IL-6 monoclonal antibody, in combination with mitoxantrone/prednisone versus mitoxantrone/prednisone alone in metastatic castration-resistant prostate cancer. Eur J Cancer 48 (2012), 85–93.
-
(2012)
Eur J Cancer
, vol.48
, pp. 85-93
-
-
Fizazi, K.1
De Bono, J.S.2
Flechon, A.3
-
8
-
-
84879786803
-
Aflibercept versus placebo in combination with docetaxel and prednisone for treatment of men with metastatic castration-resistant prostate cancer (VENICE): a phase 3, double-blind randomised trial
-
8 Tannock, IF, Fizazi, K, Ivanov, S, et al., for the VENICE Investigators. Aflibercept versus placebo in combination with docetaxel and prednisone for treatment of men with metastatic castration-resistant prostate cancer (VENICE): a phase 3, double-blind randomised trial. Lancet Oncol 14 (2013), 760–768.
-
(2013)
Lancet Oncol
, vol.14
, pp. 760-768
-
-
Tannock, I.F.1
Fizazi, K.2
Ivanov, S.3
-
9
-
-
79957953692
-
Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer
-
9 Scher, HI, Jia, X, Chi, K, et al. Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer. J Clin Oncol 29 (2011), 2191–2198.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2191-2198
-
-
Scher, H.I.1
Jia, X.2
Chi, K.3
-
10
-
-
84933497706
-
Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): a randomised, double-blind, placebo-controlled phase 3 trial
-
10 Petrylak, DP, Vogelzang, NJ, Budnik, N, et al. Docetaxel and prednisone with or without lenalidomide in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (MAINSAIL): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 16 (2015), 417–425.
-
(2015)
Lancet Oncol
, vol.16
, pp. 417-425
-
-
Petrylak, D.P.1
Vogelzang, N.J.2
Budnik, N.3
-
11
-
-
78149357044
-
Correlation between serum prostate-specific antigen and cancer volume in prostate glands of different sizes
-
11 Carvalhal, GF, Daudi, SN, Kan, D, et al. Correlation between serum prostate-specific antigen and cancer volume in prostate glands of different sizes. Urology 76 (2010), 1072–1076.
-
(2010)
Urology
, vol.76
, pp. 1072-1076
-
-
Carvalhal, G.F.1
Daudi, S.N.2
Kan, D.3
-
12
-
-
55049137067
-
Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data
-
12 Stein, WD, Figg, WD, Dahut, W, et al. Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data. Oncologist 13 (2008), 1046–1054.
-
(2008)
Oncologist
, vol.13
, pp. 1046-1054
-
-
Stein, W.D.1
Figg, W.D.2
Dahut, W.3
-
13
-
-
55049109179
-
Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage
-
13 Stein, WD, Yang, J, Bates, SE, Fojo, T, Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage. Oncologist 13 (2008), 1055–1062.
-
(2008)
Oncologist
, vol.13
, pp. 1055-1062
-
-
Stein, W.D.1
Yang, J.2
Bates, S.E.3
Fojo, T.4
-
14
-
-
70350139039
-
Other paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma
-
14 Stein, WD, Huang, H, Menefee, M, et al. Other paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma. Cancer J 15 (2009), 441–447.
-
(2009)
Cancer J
, vol.15
, pp. 441-447
-
-
Stein, W.D.1
Huang, H.2
Menefee, M.3
-
15
-
-
79951826832
-
Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy
-
15 Stein, WD, Gulley, JL, Schlom, J, et al. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy. Clin Cancer Res 17 (2011), 907–917.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 907-917
-
-
Stein, W.D.1
Gulley, J.L.2
Schlom, J.3
-
16
-
-
84859871183
-
Analyzing the pivotal trial that compared sunitinib and IFN-alpha in renal cell carcinoma, using a method that assesses tumor regression and growth
-
16 Stein, WD, Wilkerson, J, Kim, ST, et al. Analyzing the pivotal trial that compared sunitinib and IFN-alpha in renal cell carcinoma, using a method that assesses tumor regression and growth. Clin Cancer Res 18 (2012), 2374–2381.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2374-2381
-
-
Stein, W.D.1
Wilkerson, J.2
Kim, S.T.3
-
17
-
-
85007493862
-
tumgr: Tumor Growth Rate Analysis. R package version 0.0.4
-
(accessed Sept 25, 2016).
-
17 Wilkerson, J, tumgr: Tumor Growth Rate Analysis. R package version 0.0.4. http://CRAN.R-project.org/package=tumgr, 2016 (accessed Sept 25, 2016).
-
(2016)
-
-
Wilkerson, J.1
-
18
-
-
84961216962
-
A Package for Survival Analysis in S. Version 2.38
-
(accessed Sept 25, 2016).
-
18 Therneau, T, A Package for Survival Analysis in S. Version 2.38. http://CRAN.R-project.org/package=survival, 2015 (accessed Sept 25, 2016).
-
(2015)
-
-
Therneau, T.1
-
19
-
-
0021047301
-
Analysis of survival by tumor response
-
19 Anderson, JR, Cain, KC, Gelber, RD, Analysis of survival by tumor response. J Clin Oncol 1 (1983), 710–719.
-
(1983)
J Clin Oncol
, vol.1
, pp. 710-719
-
-
Anderson, J.R.1
Cain, K.C.2
Gelber, R.D.3
-
20
-
-
85007461501
-
SurvC1: C-statistics for risk prediction models with censored survival data. R package version 1.0.2
-
(accessed Sept 25, 2016).
-
20 Uno, H, SurvC1: C-statistics for risk prediction models with censored survival data. R package version 1.0.2. http://CRAN.R-project.org/package=survC1, 2013 (accessed Sept 25, 2016).
-
(2013)
-
-
Uno, H.1
-
21
-
-
84900436763
-
Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example
-
21 Burotto, M, Wilkerson, J, Stein, W, et al. Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example. PLoS One, 9, 2014, e96316.
-
(2014)
PLoS One
, vol.9
, pp. e96316
-
-
Burotto, M.1
Wilkerson, J.2
Stein, W.3
-
22
-
-
38349167518
-
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the Tax 327 study
-
22 Berthold, DR, Pond, GR, Soban, F, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer: updated survival in the Tax 327 study. J Clin Oncol 26 (2008), 242–245.
-
(2008)
J Clin Oncol
, vol.26
, pp. 242-245
-
-
Berthold, D.R.1
Pond, G.R.2
Soban, F.3
-
23
-
-
84863116743
-
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
-
23 Sosman, JA, Kim, KB, Schuchter, L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 366 (2012), 707–714.
-
(2012)
N Engl J Med
, vol.366
, pp. 707-714
-
-
Sosman, J.A.1
Kim, K.B.2
Schuchter, L.3
-
24
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
-
24 Hauschild, A, Grob, JJ, Demidov, LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380 (2012), 358–365.
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
-
25
-
-
4644341516
-
Discontinuation of imatinib therapy after achieving a molecular response
-
25 Cortes, J, O'Brien, S, Kantarjian, H, Discontinuation of imatinib therapy after achieving a molecular response. Blood 104 (2004), 2204–2205.
-
(2004)
Blood
, vol.104
, pp. 2204-2205
-
-
Cortes, J.1
O'Brien, S.2
Kantarjian, H.3
-
26
-
-
44649095050
-
Time course of imaging changes of GBM during extended bevacizumab treatment
-
26 Ananthnarayan, S, Bahng, J, Roring, J, et al. Time course of imaging changes of GBM during extended bevacizumab treatment. J Neurooncol 88 (2008), 339–347.
-
(2008)
J Neurooncol
, vol.88
, pp. 339-347
-
-
Ananthnarayan, S.1
Bahng, J.2
Roring, J.3
-
27
-
-
84867128714
-
Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agents
-
27 André, F, Zielinski, CC, Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agents. Ann Oncol 23:suppl 6 (2012), vi46–vi51.
-
(2012)
Ann Oncol
, vol.23
, pp. vi46-vi51
-
-
André, F.1
Zielinski, C.C.2
-
28
-
-
77956556274
-
Docetaxel reintroduction in patients with metastatic castration-resistant docetaxel-sensitive prostate cancer: a retrospective multicentre study
-
28 Eymard, JC, Oudard, S, Gravis, G, et al. Docetaxel reintroduction in patients with metastatic castration-resistant docetaxel-sensitive prostate cancer: a retrospective multicentre study. BJU Int 106 (2010), 974–978.
-
(2010)
BJU Int
, vol.106
, pp. 974-978
-
-
Eymard, J.C.1
Oudard, S.2
Gravis, G.3
-
29
-
-
84971639081
-
The Prostate Cancer Working Group 3 (PCWG3) consensus for trials in castration-resistant prostate cancer (CRPC)
-
abstr 5000.
-
29 Scher, HI, Morris, MJ, Stadler, WM, et al. The Prostate Cancer Working Group 3 (PCWG3) consensus for trials in castration-resistant prostate cancer (CRPC). Proc Am Soc Clin Oncol, 33(suppl), 2015 abstr 5000.
-
(2015)
Proc Am Soc Clin Oncol
, vol.33
-
-
Scher, H.I.1
Morris, M.J.2
Stadler, W.M.3
-
30
-
-
84904043247
-
Update on second primary malignancies in multiple myeloma: a focused review
-
30 Landgren, O, Mailankody, S, Update on second primary malignancies in multiple myeloma: a focused review. Leukemia 28 (2014), 1423–1426.
-
(2014)
Leukemia
, vol.28
, pp. 1423-1426
-
-
Landgren, O.1
Mailankody, S.2
-
31
-
-
84925457199
-
Complex decisions for first-line and maintenance treatment of advanced wild-type non-small cell lung cancer
-
31 Gentzler, RD, Johnson, ML, Complex decisions for first-line and maintenance treatment of advanced wild-type non-small cell lung cancer. Oncologist 20 (2015), 299–306.
-
(2015)
Oncologist
, vol.20
, pp. 299-306
-
-
Gentzler, R.D.1
Johnson, M.L.2
-
32
-
-
84871600705
-
Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea
-
32 Gerber, DE, Schiller, JH, Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea. J Clin Oncol 31 (2013), 1009–1020.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1009-1020
-
-
Gerber, D.E.1
Schiller, J.H.2
-
33
-
-
84920857824
-
A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC)
-
33 Lange, A, Prenzler, A, Frank, M, et al. A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC). BMC Pulm Med, 14, 2014, 192.
-
(2014)
BMC Pulm Med
, vol.14
, pp. 192
-
-
Lange, A.1
Prenzler, A.2
Frank, M.3
-
34
-
-
84906345112
-
Impact on overall survival (OS) with chemohormonal therapy versus hormonal therapy for hormone-sensitive newly metastatic prostate cancer (mPrCa): an ECOG-led phase III randomized trial
-
abstr LBA2.
-
34 Sweeney, C, Chen, Y-H, Carducci, MA, et al. Impact on overall survival (OS) with chemohormonal therapy versus hormonal therapy for hormone-sensitive newly metastatic prostate cancer (mPrCa): an ECOG-led phase III randomized trial. Proc Am Soc Clin Oncol, 32(5 suppl), 2014 abstr LBA2.
-
(2014)
Proc Am Soc Clin Oncol
, vol.32
, Issue.5
-
-
Sweeney, C.1
Chen, Y.-H.2
Carducci, M.A.3
-
35
-
-
84879469745
-
Phase III trials with docetaxel-based combinations for metastatic castration-resistant prostate cancer: time to learn from experiences
-
35 Antonarakis, ES, Eisenberger, MA, Phase III trials with docetaxel-based combinations for metastatic castration-resistant prostate cancer: time to learn from experiences. J Clin Oncol 31 (2013), 1709–1712.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1709-1712
-
-
Antonarakis, E.S.1
Eisenberger, M.A.2
|