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Angewandte Chemie - International Edition

Volumn 56, Issue 5, 2017, Pages 1294-1297

Azaindoles as Zinc-Binding Small-Molecule Inhibitors of the JAMM Protease CSN5

(16) Altmann, Eva a Erbel, Paul a Renatus, Martin a Schaefer, Michael a Schlierf, Anita a Druet, Adelaide a Kieffer, Laurence a Sorge, Mickael a Pfister, Keith a,b Hassiepen, Ulrich a Jones, Matthew a Ruedisser, Simon a Ostermeier, Daniela a Martoglio, Bruno a,c Jefferson, Anne B b,d Quancard, Jean a

a NOVARTIS PHARMA AG (Switzerland)

b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

c F HOFFMANN LA ROCHE LTD (Switzerland)

d PFIZER INC (United States)

Author keywords

azaindoles; CSN5; inhibitors; metalloproteases; ubiquitin ligases

Indexed keywords

BINDING ENERGY; CORROSION INHIBITORS; ENZYMES;

AZAINDOLES; CSN5; E3 UBIQUITIN LIGASES; METALLOPROTEASES; SMALL MOLECULE INHIBITOR; SUBSTRATE RECOGNITION; UBIQUITIN LIGASES; ZINC METALLOPROTEASE;

ZINC;

COP9 SIGNALOSOME; INDOLE DERIVATIVE; NEDD8 PROTEIN; NEDD8 PROTEIN, HUMAN; S PHASE KINASE ASSOCIATED PROTEIN; SKP2 PROTEIN, HUMAN; SMALL INTERFERING RNA; ZINC;

ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVE SITE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; HCT 116 CELL LINE; HUMAN; METABOLISM; MOLECULAR DOCKING; PROTEIN SUBUNIT; RNA INTERFERENCE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATALYTIC DOMAIN; CELL PROLIFERATION; COP9 SIGNALOSOME COMPLEX; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HCT116 CELLS; HUMANS; INDOLES; MOLECULAR DOCKING SIMULATION; NEDD8 PROTEIN; PROTEIN SUBUNITS; RNA INTERFERENCE; RNA, SMALL INTERFERING; S-PHASE KINASE-ASSOCIATED PROTEINS; ZINC;

EID: 85007304216 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201608672 Document Type: Article

Times cited : (19)

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