Iron concentration in breast milk normalised within one week of a single high-dose infusion of iron isomaltoside in randomised controlled trial

Acta Paediatrica, International Journal of Paediatrics

Volumn 106, Issue 2, 2017, Pages 256-260

  Holm, Charlotte ^a,b   Thomsen, Lars Lykke ^b   Norgaard, Astrid ^a   Markova, Veronika ^a,b   Michaelsen, Kim F ^a   Langhoff Roos, Jens ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Pharmacosmos AS   (Denmark)

Author keywords

Breast milk composition; Intravenous iron isomaltoside; Lactation; Oral iron; Postpartum haemorrhage

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; IRON ISOMALTOSIDE; TRANSFERRIN; UNCLASSIFIED DRUG; DISACCHARIDE; FERRIC ION; IRON ISOMALTOSIDE 1000;

ADULT; ARTICLE; BLOOD SAMPLING; BREAST MILK; CLINICAL EVALUATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INFUSION; DRUG MEGADOSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL BLOOD; MILK PRODUCTION; OUTCOME ASSESSMENT; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TREATMENT DURATION; VITAMIN SUPPLEMENTATION; CHEMISTRY; INTRAVENOUS DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADULT; DISACCHARIDES; FEMALE; FERRIC COMPOUNDS; HUMANS; INFUSIONS, INTRAVENOUS; IRON; MILK, HUMAN; POSTPARTUM HEMORRHAGE;

EID: 85007106735     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/apa.13681     Document Type: Article

References (27)

1. Lönnerdal B. Trace element transport in the mammary gland. Annu Rev Nutr 2007; 27: 165–77.
2. Domellöf M, Lönnerdal B, Dewey KG, Cohen RJ, Hernell O. Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status. Am J Clin Nutr 2004; 79: 111–5.
3. Kelleher SL, Lönnerdal B. Low vitamin A intake affects milk iron level and iron transporters in rat mammary gland and liver. J Nutr 2005; 135: 27–32.
4. Nakamori M, Ninh NX, Isomura H, Yoshiike N, Hien VTT, Nhug BT, et al. Nutritional status of lactating mothers and their breast milk concentration of iron, zinc and copper in rural Vietnam. J Nutr Sci Vitaminol 2009; 55: 338–45.
5. Yalcin SS, Baykan A, Yurdakök K, Yalcin S, Gücüs AI. The factors that affect milk-to-serum ratio for iron during early lactation. J Pediatr Hematol Oncol 2009; 31: 85–90.
6. Lönnerdal B. Effects of maternal dietary intake on human milk composition. J Nutr 1986; 116: 499–513.
7. Zavaleta N, Nombera J, Rojas R, Hambraeus L, Gislason J, Lönnerdal B. Iron and lactoferrin in milk of anemic mothers given iron supplements. Nutr Res 1995; 15: 1681–90.
8. Kumar A, Rai AK, Basu S, Dash D, Singh JS. Cord blood and breast milk iron status in maternal anemia. Pediatrics 2008; 121: 673–7.
9. França EL, Silva VA, Volpato RMJ, Silva PA, Brune MFSS, Honorio-França AC. Maternal anemia induces changes in immunological and nutritional components of breast milk. J Matern Fetal Neonatal Med 2013; 26: 1223–7.
10. Quinn EA. Too much of a good thing: evolutionary perspectives on infant formula fortification in the United States and its effects on infant health. Am J Hum Biol 2014; 26: 10–7.
11. Dorea JG. Iron and copper in human milk. Nutrition 2000; 16: 209–20.
12. Feeley RM, Eitenmiller RR, Jones JB, Barnhart H. Copper, iron, and zinc contents of human milk at early stages of lactation. Am J Clin Nutr 1983; 37: 443–8.
13. Siimes MA, Vuori E, Kuitunen P. Breast milk iron – a declining concentration during the course of lactation. Acta Paediatr Scand 1979; 68: 29–31.
14. Fransson GB, Lönnerdal B. Iron in human milk. J Pediatr 1980; 96: 380–4.
15. Domellöf M, Lönnerdal B, Abrams SA, Hernell O. Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am J Clin Nutr 2002; 76: 198–204.
16. Hicks PD, Zavaleta N, Chen Z, Abrams SA, Lönnerdal B. Iron deficiency, but not anemia, upregulates iron absorption in breast-fed peruvian infants. J Nutr 2006; 136: 2435–8.
17. American Academy of Pediatrics. Committee on Nutrition. Iron fortification of infant formulas. Pediatrics 1999; 104: 119–23.
18. Saarinen UM, Siimes MA. Iron absorption from infant milk formula and the optimal level of iron supplementation. Acta Paediatr Scand 1977; 66: 719–22.
19. Koletzko B, Baker S, Cleghorn G, Neto UF, Gopalan S, Hernell O, et al. Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J Pediatr Gastroenterol Nutr 2005; 41: 584–99.
20. Baker RD, Greer FR, Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0–3 years of age). Pediatrics 2010; 126: 1040–50.
21. Domellöf M, Braegger C, Campoy C, Colomb V, Decsi T, Fewtrell M, et al. Iron requirements of infants and toddlers. J Pediatr Gastroenterol Nutr 2014; 58: 119–29.
22. Bullen JJ, Ward CG, Rogers HJ. The critical role of iron in some clinical infections. Eur J Clin Microbiol Infect Dis 1991; 10: 613–7.
23. Domellöf M. Iron requirements, absorption and metabolism in infancy and childhood. Curr Opin Clin Nutr Metab Care 2007; 10: 329–35.
24. Moy RJ. Iron fortification of infant formula. Nutr Res Rev 2000; 13: 215–27.
25. Holm C, Thomsen LL, Norgaard A, Langhoff-Roos J. Intravenous iron isomaltoside 1000 administered by single high-dose infusions or standard medical care for the treatment of fatigue in women after postpartum haemorrhage: study protocol for a randomised controlled trial. Trials 2015; 16: 1–8.
26. Breymann C, von Seefried B, Stahel M, Geisser P, Canclini C. Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex. J Perinat Med 2007; 35: 115–8.
27. Breymann C, Gliga F, Bejenariu C, Strizhova N. Comparative efficacy and safety of intravenous ferric carboxymaltose in the treatment of postpartum iron deficiency anemia. Int J Gynaecol Obstet 2008; 101: 67–73.