A prenatal multiple micronutrient supplement produces higher maternal vitamin B-12 concentrations and similar folate, ferritin, and zinc concentrations as the standard 60-mg iron plus 400-mg folic acid supplement in rural bangladeshi women

Journal of Nutrition

Volumn 146, Issue 12, 2016, Pages 2520-2529

  Ziaei, Shirin ^a   Rahman, Anisur ^b   Raqib, Rubhana ^b   Lönnerdal, Bo ^c   Ekström, Eva Charlotte ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bangladesh; Effectiveness; Efficacy; Ferritin; Folate; Food supplementation; Maternal micronutrient status; Prenatal micronutrient supplementation; Vitamin B 12; Zinc

Indexed keywords

CYANOCOBALAMIN; FERRITIN; FOLIC ACID; IRON; TRACE ELEMENT; ZINC;

ADULT; ARTICLE; BANGLADESHI; BLOOD SAMPLING; DIET SUPPLEMENTATION; FEMALE; FIRST TRIMESTER PREGNANCY; FOLLOW UP; HUMAN; IRON INTAKE; MAJOR CLINICAL STUDY; PREGNANT WOMAN; RURAL AREA; THIRD TRIMESTER PREGNANCY; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; ZINC BLOOD LEVEL; BANGLADESH; BLOOD; CONTROLLED STUDY; DIET; DIETARY SUPPLEMENT; EPIDEMIOLOGY; MATERNAL NUTRITION; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; RURAL POPULATION;

BANGLADESH; DIET; DIETARY SUPPLEMENTS; FEMALE; FERRITINS; FOLIC ACID; HUMANS; IRON; PREGNANCY; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; RURAL POPULATION; VITAMIN B 12; ZINC;

EID: 85006998578     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.116.235994     Document Type: Article

References (32)

1. Peña-Rosas JP, De-Regil LM, Garcia-Casal MN, Dowswell T. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev 2015;7:CD004736.
2. Ezzati M, Lopez A, Rodgers A, Murray C. Comparative quantification of health risks: the global and regional burden of disease attributable to selected major risk factors. Geneva (Switzerland): World Health Organization; 2004.
3. Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, Ezzati M, Mathers C, Rivera J. Maternal and child undernutrition: global and regional exposures and health consequences. Lancet 2008;371:243-60.
4. Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev 2015;11:CD004905.
5. Sloan NL, Jordan E, Winikoff B. Effects of iron supplementation on maternal hematologic status in pregnancy. Am J Public Health 2002;92:288-93.
6. Ramakrishnan U. Prevalence of micronutrient malnutrition worldwide. Nutr Rev 2002;60:S46-52.
7. Allen LH. Multiple micronutrients in pregnancy and lactation: an overview. Am J Clin Nutr 2005;81(Suppl):1206S-12S.
8. Christian P, Stewart CP. Maternal micronutrient deficiency, fetal development, and the risk of chronic disease. J Nutr 2010;140:437-45.
9. UNICEF; WHO; United Nations University. Composition of a multimicronutrient supplement to be used in pilot programmes among pregnant women in developing countries: report of a United Nations Children's Fund (UNICEF), World Health Organization (WHO) and United Nations University workshop. New York: UNICEF; 1999.
10. Allen LH, Peerson JM. Impact of multiple micronutrient versus ironfolic acid supplements on maternal anemia and micronutrient status in pregnancy. Food Nutr Bull 2009;30:S527-32.
11. Persson LA, Arifeen S, Ekstrom EC, Rasmussen KM, Frongillo EA, Yunus M. Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial. JAMA 2012;307:2050-9.
12. Ekström EC, Hyder SM, Chowdhury AM, Chowdhury SA, Lonnerdal B, Habicht JP, Persson LA. Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues. Am J Clin Nutr 2002;76:1392-400.
13. Ekström EC, Kavishe FP, Habicht JP, Frongillo EA Jr., Rasmussen KM, Hemed L. Adherence to iron supplementation during pregnancy in Tanzania: determinants and hematologic consequences. Am J Clin Nutr 1996;64:368-74.
14. Lindström E, Hossain MB, Lonnerdal B, Raqib R, El Arifeen S, Ekstrom EC. Prevalence of anemia and micronutrient deficiencies in early pregnancy in rural Bangladesh, the MINIMat trial. Acta Obstet Gynecol Scand 2011;90:47-56.
15. Clegg MS, Keen CL, Lonnerdal B, Hurley LS. Influence of ashing techniques on the analysis of trace elements in animal tissue: I. Wet ashing. Biol Trace Elem Res 1981;3:107-15.
16. Marshall SW. Power for tests of interaction: effect of raising the type I error rate. Epidemiol Perspect Innov 2007;4:4.
17. Christian P, Jiang T, Khatry SK, LeClerq SC, Shrestha SR, West KP Jr. Antenatal supplementation with micronutrients and biochemical indicators of status and subclinical infection in rural Nepal. Am J Clin Nutr 2006;83:788-94.
18. Van Sande H, Jacquemyn Y, Karepouan N, Ajaji M. Vitamin B12 in pregnancy: maternal and fetal/neonatal effects-a review. Open J Obstet Gynecol 2013;3:599-602.
19. Berti C, Fekete K, Dullemeijer C, Trovato M, Souverein OW, Cavelaars A, Dhonukshe-Rutten R, Massari M, Decsi T, Van't Veer P, et al. Folate intake and markers of folate status in women of reproductive age, pregnant and lactating women: a meta-analysis. J Nutr Metab 2012;2012:470656.
20. Hininger I, Favier M, Arnaud J, Faure H, Thoulon JM, Hariveau E, Favier A, Roussel AM. Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women. Eur J Clin Nutr 2004;58:52-9.
21. Yajnik CS, Deshpande SS, Jackson AA, Refsum H, Rao S, Fisher DJ, Bhat DS, Naik SS, Coyaji KJ, Joglekar CV, et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia 2008;51:29-38.
22. Lee JI, Lee JA, Lim HS. Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy. Am J Clin Nutr 2005;82:843-9.
23. Weinberg ED. Are iron supplements appropriate for iron replete pregnant women? Med Hypotheses 2009;73:714-5.
24. Tarim E, Kilicdag E, Bagis T, Ergin T. High maternal hemoglobin and ferritin values as risk factors for gestational diabetes. Int J Gynaecol Obstet 2004;84:259-61.
25. Lee DH, Folsom AR, Jacobs DR. Iron, zinc, and alcohol consumption and mortality from cardiovascular diseases: the Iowa Women's Health Study. Am J Clin Nutr 2005;81:787-91.
26. Black RE. Micronutrients in pregnancy. Br J Nutr 2001;85:S193-7.
27. Muslimatun S, Schmidt MK, Schultink W, West CE, Hautvast JGAJ, Gross R, Muhilal.Weekly supplementation with iron and vitamin A during pregnancy increases hemoglobin concentration but decreases serum ferritin concentration in Indonesian pregnant women. J Nutr 2001;131:85-90.
28. Ramakrishnan U, Neufeld LM, Gonzalez-Cossio T, Villalpando S, Garcia-Guerra A, Rivera J, Martorell R. Multiple micronutrient supplements during pregnancy do not reduce anemia or improve iron status compared to iron-only supplements in semirural Mexico. J Nutr 2004;134:898-903.
29. Brough L, Rees GA, Crawford MA, Morton RH, Dorman EK. Effect of multiple-micronutrient supplementation on maternal nutrient status, infant birth weight and gestational age at birth in a low-income, multiethnic population. Br J Nutr 2010;104:437-45.
30. Sunawang, Utomo B, Hidayat A, Kusharisupeni, Subarkah. Preventing low birthweight through maternal multiple micronutrient supplementation: a cluster-randomized, controlled trial in Indramayu, West Java. Food Nutr Bull 2009;30:S488-95.
31. Sandström B. Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 2001;85:S181-5.
32. Caulfield LE, Zavaleta N, Figueroa A. Adding zinc to prenatal iron and folate supplements improves maternal and neonatal zinc status in a Peruvian population. Am J Clin Nutr 1999;69:1257-63.