The Effect of Aerosol Saline on Laboratory-Induced Dyspnea

Lung

Volumn 195, Issue 1, 2017, Pages 37-42

  O'Donnell C R ^a,b   Lansing, R W ^a   Schwartzstein, R M ^a,b   Banzett, Robert ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aerosol treatment; Dyspnea; Placebo; Symptom management

Indexed keywords

SODIUM CHLORIDE;

AEROSOL; ARTICLE; BEHAVIOR; BREATHING; CALCULATION; DYSPNEA; HYPERCAPNIA; INHALATION; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; TACHYPNEA; TIDAL VOLUME; VENTILATOR; ADULT; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; MECHANICAL VENTILATOR; PLACEBO EFFECT; THERAPEUTIC USE;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; DYSPNEA; FEMALE; HUMANS; MALE; PLACEBO EFFECT; SODIUM CHLORIDE; VENTILATORS, MECHANICAL;

EID: 85006943977     PISSN: 03412040     EISSN: 14321750     Source Type: Journal    
DOI: 10.1007/s00408-016-9971-3     Document Type: Article

References (23)

1. Stone P, Kurowska A, Tookman A (1994) Nebulized frusemide for dyspnoea. Palliat Med 8(3):258
2. Moosavi SH, Binks AP, Lansing RW et al (2007) Effect of inhaled furosemide on air hunger induced in healthy humans. Respir Physiol Neurobiol 156(1):1–8
3. Nishino T, Ide T, Sudo T et al (2000) Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea. Am J Respir Crit Care Med 161(6):1963–1967
4. Shimoyama N, Shimoyama M (2002) Nebulized furosemide as a novel treatment for dyspnea in terminal cancer patients. J Pain Symptom Manag 23(1):73–76
5. Kohara H, Ueoka H, Aoe K et al (2003) Effect of nebulized furosemide in terminally ill cancer patients with dyspnea. J Pain Symptom Manag 26(4):962–967
6. Wilcock A, Walton A, Manderson C et al (2008) Randomised, placebo controlled trial of nebulised furosemide for breathlessness in patients with cancer. Thorax 63(10):872–875
7. Ong KC, Kor AC, Chong WF et al (2004) Effects of inhaled furosemide on exertional dyspnea in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 169(9):1028–1033
8. Jensen D, Amjadi K, Harris-McAllister V et al (2008) Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD. Thorax 63(7):606–613
9. Panahi Y, Motiei-Langroudi R, Alaeddini F et al (2008) Furosemide inhalation in dyspnea of mustard gas-exposed patients: a triple-blind randomized study. Inhal Toxicol 20(9):873–877
10. Banzett RB, Adams L, O’Donnell CR et al (2011) Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. Am J Respir Crit Care Med 184(8):920–927. doi:10.1164/rccm.201101-0005OC
11. Wall PD (1993) Pain and the placebo response. Ciba Found Symp 174:187–211 discussion 212–186
12. Reicherts P, Gerdes AB, Pauli P et al (2016) Psychological placebo and nocebo effects on pain rely on expectation and previous experience. J Pain 17(2):203–214. doi:10.1016/j.jpain.2015.10.010
13. O’Donnell CR, Schwartzstein RM, Lansing RW et al (2013) Dyspnea affective response: comparing COPD patients with healthy volunteers and laboratory model with activities of daily living. BMC Pulm Med 13:27. doi:10.1186/1471-2466-13-27
14. Moosavi SH, Golestanian E, Binks AP et al (2003) Hypoxic and hypercapnic drives to breathe generate equivalent levels of air hunger in humans. J Appl Physiol 94(1):141–154
15. 2-induced air hunger. Respir Physiol 105(1–2):47–55
16. Banzett RB, O’Donnell CR, Guilfoyle TE et al (2015) Multidimensional Dyspnea Profile: an instrument for clinical and laboratory research. Eur Respir J 45(6):1681–1691. doi:10.1183/09031936.00038914
17. Vovk A, Binks AP (2007) Raising end-expiratory volume relieves air hunger in mechanically ventilated healthy adults. J Appl Physiol 103(3):779–786. doi:10.1152/japplphysiol.01185.2006
18. Holmes RD, Tiwari AK, Kennedy JL (2016) Mechanisms of the placebo effect in pain and psychiatric disorders. Pharmacogen J. doi:10.1038/tpj.2016.15
19. Price DD, Finniss DG, Benedetti F (2008) A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol 59:565–590. doi:10.1146/annurev.psych.59.113006.095941
20. Evans KC, Banzett RB, Adams L et al (2002) BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger. J Neurophysiol 88(3):1500–1511
21. Poole PJ, Brodie SM, Stewart JM et al (1998) The effects of nebulised isotonic saline and terbutaline on breathlessness in severe chronic obstructive pulmonary disease (COPD). Aust N Z J Med 28(3):322–326
22. Khan SY, O’Driscoll BR (2004) Is nebulized saline a placebo in COPD? BMC Pulm Med 4:9. doi:10.1186/1471-2466-4-9
23. Pisarri TE, Jonzon A, Coleridge HM et al (1992) Vagal afferent and reflex responses to changes in surface osmolarity in lower airways of dogs. J Appl Physiol 73(6):2305–2313