Effects of antipsychotics on intestinal motility in zebrafish larvae

Neurogastroenterology and Motility

Volumn 29, Issue 5, 2017, Pages

  de Alvarenga, K A F ^a   Sacramento, E K ^a   Rosa, D V ^a   Souza, B R ^a   de Rezende, V B ^a   Romano Silva, M A ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

anticholinergic; antipsychotics; clozapine; Danio rerio; gastrointestinal transit; gut motility; haloperidol; intestine; risperidone; side effects; zebrafish

Indexed keywords

ATROPINE; CLOZAPINE; HALOPERIDOL; NEUROLEPTIC AGENT; RISPERIDONE; MUSCARINIC RECEPTOR BLOCKING AGENT;

ADULT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL MOTILITY DISORDER; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; IN VIVO STUDY; INTESTINE CONTRACTION; INTESTINE MOTILITY; LARVA; NONHUMAN; PERISTALSIS; PRIORITY JOURNAL; ZEBRA FISH; ANIMAL; DRUG EFFECTS; PRECLINICAL STUDY; PROCEDURES;

ANIMALS; ANTIPSYCHOTIC AGENTS; ATROPINE; CLOZAPINE; DRUG EVALUATION, PRECLINICAL; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; HALOPERIDOL; LARVA; MUSCARINIC ANTAGONISTS; RISPERIDONE; ZEBRAFISH;

EID: 85006856323     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.13006     Document Type: Article

References (36)

1. Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov. 2004;3:353–359. Available from: http://www.nature.com/doifinder/10.1038/nrd1346
2. Uçok A, Gaebel W. Side effects of atypical antipsychotics: a brief overview. World Psychiatry. 2008;7:58–62.
3. Lieberman JA. Managing anticholinergic side effects. Prim Care Companion J Clin Psychiatry. 2004;6(Suppl 2):20–23.
4. Palmer SE, McLean RM, Ellis PM, Harrison-Woolrych M. Life-threatening clozapine-induced gastrointestinal hypomotility. J Clin Psychiatry. 2008;69:759–768.
5. Stewart AM, Ullmann JFP, Norton WHJ, et al. Molecular psychiatry of zebrafish. Mol Psychiatry. 2015;20:2–17.
6. Wenner M. The most transparent research. Nat Med. 2009;15:1106–1109.
7. White RM, Sessa A, Burke C, et al. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell. 2008;2:183–189. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1934590907002755
8. Wallace KN, Akhter S, Smith EM, Lorent K, Pack M. Intestinal growth and differentiation in zebrafish. Mech Dev. 2005;122:157–173.
9. Holmberg A, Olsson C, Hennig GW. TTX-sensitive and TTX-insensitive control of spontaneous gut motility in the developing zebrafish (Danio rerio) larvae. J Exp Biol. 2007;210:1084–1091.
10. Ball ER, Matsuda MM, Dye L, et al. Ultra-structural identification of interstitial cells of cajal in the zebrafish Danio rerio. Cell Tissue Res. 2012;349:483–491. Available from: http://link.springer.com/10.1007/s00441-012-1434-4
11. Holmberg A. Ontogeny of the gut motility control system in zebrafish Danio rerio embryos and larvae. J Exp Biol. 2004;207:4085–4094.
12. Holmberg A. The effects of endogenous and exogenous nitric oxide on gut motility in zebrafish Danio rerio embryos and larvae. J Exp Biol. 2006;209:2472–2479.
13. Zhou J, Guo S-Y, Zhang Y, Li C-Q. Human prokinetic drugs promote gastrointestinal motility in zebrafish. Neurogastroenterol Motil. 2014;26:589–595.
14. Parker MO, Brock AJ, Millington ME, Brennan CH. Behavioral phenotyping of casper mutant and 1-pheny-2-thiourea treated adult zebrafish. Zebrafish. 2013;10:466–471. Available from: http://online.liebertpub.com/doi/abs/10.1089/zeb.2013.0878
15. Antinucci P, Hindges R. A crystal-clear zebrafish for in vivo imaging. Sci Rep. 2016;6:29490. Available from: http://dx.doi.org/10.1038/srep29490
16. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B, Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn. 1995;203:253–310. Available from: http://doi.wiley.com/10.1002/aja.1002030302
17. Westerfield M. The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio). 5th ed. Eugene, Oregon, USA: University of Oregon Press; 2007.
18. Giacomini NJ, Rose B, Kobayashi K, Guo S. Antipsychotics produce locomotor impairment in larval zebrafish. Neurotoxicol Teratol. 2006;28:245–250. Available from: http://linkinghub.elsevier.com/retrieve/pii/S089203620600033X
19. Irons TD, Kelly PE, Hunter DL, MacPhail RC, Padilla S. Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish. Pharmacol Biochem Behav. 2013;103:792–813. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0091305712003346
20. Rihel J, Prober DA, Arvanites A, et al. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science. 2010;327:348–351. Available from: http://www.sciencemag.org/cgi/doi/10.1126/science.1183090
21. Bruni G, Rennekamp AJ, Velenich A, et al. Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nat Chem Biol; 2016;12:559–566. Available from: http://www.nature.com/doifinder/10.1038/nchembio.2097
22. Hill AJ. Zebrafish as a model vertebrate for investigating chemical toxicity. Toxicol Sci. 2005;86:6–19. Available from: http://www.toxsci.oupjournals.org/cgi/doi/10.1093/toxsci/kfi110
23. Roth BL, Sheffler D, Potkin SG. Atypical antipsychotic drug actions: unitary or multiple mechanisms for “atypicality”?. Clin Neurosci Res. 2003;3:108–117. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1566277203000215
24. Leucht S, Cipriani A, Spineli L, et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet. 2013;382:951–962. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0140673613607333
25. Capuano B, Crosby I, Lloyd E. Schizophrenia: genesis, receptorology and current therapeutics. Curr Med Chem. 2002;9:521–48. Available from: http://www.eurekaselect.com/openurl/content.php?genre=article&issn=0929-8673&volume=9&issue=5&spage=521
26. Lally J, MacCabe JH. Antipsychotic medication in schizophrenia: a review. Br Med Bull. 2015;114:169–179. Available from: http://bmb.oxfordjournals.org/lookup/doi/10.1093/bmb/ldv017
27. Ozbilen M, Adams CE. Systematic overview of cochrane reviews for anticholinergic effects of antipsychotic drugs. J Clin Psychopharmacol. 2009;29:141–146. Available from: http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00004714-200904000-00006
28. Hibbard KR, Propst A, Frank DE, Wyse J. Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports. Psychosomatics. 2009;50:416–419. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0033318209708278
29. Levin TT, Barrett J, Mendelowitz A. Death from clozapine-induced constipation: case report and literature review. Psychosomatics. 2002;43:71–73. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0033318202704386
30. Tigchelaar EF, Bonder MJ, Jankipersadsing SA, Fu J, Wijmenga C, Zhernakova A. Gut microbiota composition associated with stool consistency. Gut. 2016;65:540–542. Available from: http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2015-310328
31. Vandeputte D, Falony G, Vieira-Silva S, Tito RY, Joossens M, Raes J. Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates. Gut. 2016;65:57–62. Available from: http://dx.doi.org/10.1136
32. Sirois FJ. Haloperidol-Induced Ileus. Psychosomatics. 2005;46:275–276. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0033318205700931
33. Maltbie AA, Varia IG, Thomas NU. Ileus complicating haloperidol therapy. Psychosomatics. 1981;22:158–159. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0033318281735503
34. Sheikh RA, Prindiville T, Yasmeen S. Haloperidol and benztropine interaction presenting as acute intestinal pseudo-obstruction. Am J Gastroenterol. 2001;96:934–935. Available from: http://www.nature.com/doifinder/10.1111/j.1572-0241.2001.03660.x
35. Kattimani S, Ramamourthy P, Kumaran A. Risperidone associated paralytic ileus in schizophrenia. Indian J Psychol Med. 2013;35:87. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701367
36. Lim DK, Mahendran R. Risperidone and megacolon. Singapore Med J. 2002;43:530–532.