No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1∗07:01-Restricted Lapatinib-Induced Liver Injury

Chemical Research in Toxicology

Volumn 29, Issue 12, 2016, Pages 2111-2113

  Faulkner, Lee ^a   Meng, Xiaoli ^a   Naisbitt, Dean J ^a   Spraggs, Colin F ^b   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALDEHYDE; AMINE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CD20 ANTIGEN; CD68 ANTIGEN; HLA DRB1 ANTIGEN; HYDROQUINONE; IMINE; LAPATINIB; PLACEBO; QUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLELE; ANTIGEN PRESENTATION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; B LYMPHOCYTE; BILIRUBIN BLOOD LEVEL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DRUG SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGENETICS; MACROPHAGE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; REACTION ANALYSIS; T LYMPHOCYTE ACTIVATION; TANDEM MASS SPECTROMETRY; TOXIC HEPATITIS; BLOOD; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; T LYMPHOCYTE;

ANTINEOPLASTIC AGENTS; CHEMICAL AND DRUG INDUCED LIVER INJURY; HLA-DRB1 CHAINS; HUMANS; LYMPHOCYTE ACTIVATION; QUINAZOLINES; T-LYMPHOCYTES;

EID: 85006817802     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/acs.chemrestox.6b00400     Document Type: Article

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