Abnormal myosin phosphatase targeting subunit 1 phosphorylation and actin polymerization contribute to impaired myogenic regulation of cerebral arterial diameter in the type 2 diabetic Goto-Kakizaki rat

Journal of Cerebral Blood Flow and Metabolism

Volumn 37, Issue 1, 2017, Pages 227-240

  Abd Elrahman, Khaled S ^a   Colinas, Olaia ^a   Walsh, Emma J ^a   Zhu, Hai Lei ^a   Campbell, Christine M ^a   Walsh, Michael P ^a   Cole, William C ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Ca2+ sensitization; cerebral arteries; Goto Kakizaki; Rho associated kinase; type 2 diabetes

Indexed keywords

CALCIUM; F ACTIN; FOCAL ADHESION KINASE; G ACTIN; GLUCOSE; INSULIN; MYOSIN LIGHT CHAIN PHOSPHATASE; MYOSIN LIGHT CHAIN PHOSPHATASE SUBUNIT 1; PROTEIN KINASE C; RHO KINASE; RHO KINASE 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ACTIN;

ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERY CONSTRICTION; ARTERY DIAMETER; ARTICLE; BRAIN ARTERY; BRAIN BLOOD FLOW; CEREBRAL MYOGENIC CONSTRICTION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; GOTO KAKIZAKI RAT; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; MALE; MYOGRAPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SENSITIZATION; ANIMAL; ANTAGONISTS AND INHIBITORS; INBRED RAT STRAIN; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; POLYMERIZATION; VASOCONSTRICTION;

ACTINS; ANIMALS; CALCIUM; CEREBRAL ARTERIES; DIABETES MELLITUS, TYPE 2; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; POLYMERIZATION; RATS; RATS, INBRED STRAINS; RHO-ASSOCIATED KINASES; VASOCONSTRICTION;

EID: 85006511789     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X15622463     Document Type: Article

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