Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression

British Journal of Dermatology

Volumn 176, Issue 1, 2017, Pages 265-269

  Chew, E G Y ^a   Ho, B S Y ^b   Ramasamy, S ^b   Dawson, T ^b   Tennakoon, C ^c   Liu, X ^a   Leong, W M S ^d   Yang, S Y S ^d   Lim, S Y D ^d   Jaffar, H ^d,e   Hillmer, A M ^a   Bigliardi Qi, M ^b   Bigliardi, P L ^b,d,e  

^a GENOME INSTITUTE OF SINGAPORE   (Singapore)

^b INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^c UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXIREDOXIN 3; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; TRANSCRIPTOME;

ADULT; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY; DISEASE COURSE; EPILUMINESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; HAIR CELL; HAIR FOLLICLE; HAIR ROOT; HUMAN; LETTER; MALE; MALE TYPE ALOPECIA; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RNA SEQUENCE; SCALP HAIR; AGED; ALOPECIA; CASE CONTROL STUDY; GENETICS; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; PROCEDURES; UPREGULATION; YOUNG ADULT;

ADULT; AGED; ALOPECIA; CASE-CONTROL STUDIES; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; HAIR FOLLICLE; HUMANS; MALE; MIDDLE AGED; OXIDATION-REDUCTION; UP-REGULATION; YOUNG ADULT;

EID: 85006380568     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.14767     Document Type: Letter

References (14)

1. Hamilton JB. Patterned loss of hair in man: types and incidence. Ann N Y Acad Sci 1951; 53:708–28.
2. Hamilton JB. Male hormone stimulation is prerequisite and an incitant in common baldness. Am J Anat 1942; 71:451–80.
3. Hillmer AM, Hanneken S, Ritzmann S et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet 2005; 77:140–8.
4. Blume-Peytavi U, Blumeyer A, Tosti A et al. S1 guideline for diagnostic evaluation in androgenetic alopecia in men, women and adolescents. Br J Dermatol 2011; 164:5–15.
5. de Lacharrière O, Deloche C, Misciali C et al. Hair diameter diversity: a clinical sign reflecting the follicle miniaturization. Arch Dermatol 2001; 137:641–6.
6. Ziller C. Pattern formation in neural crest derivatives. In: Hair Research for the Next Millennium (Van Neste D, Randall VA, Baden N, Ogawa H, Oliver R, eds). Amsterdam: Elsevier Science, 1996; 19–23.
7. Elahian F, Sepehrizadeh Z, Moghimi B, Mirzaei SA. Human cytochrome b5 reductase: structure, function, and potential applications. Crit Rev Biotechnol 2014; 34:134–43.
8. Horsefield R, Yankovskaya V, Sexton G et al. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem 2006; 281:7309–16.
9. Kumar V, Kitaeff N, Hampton MB et al. Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Lett 2009; 583:997–1000.
10. Fernandes AP, Holmgren A. Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid Redox Signal 2004; 6:63–74.
11. Thomas JP, Geiger PG, Maiorino M et al. Enzymatic reduction of phospholipid and cholesterol hydroperoxides in artificial bilayers and lipoproteins. Biochim Biophys Acta 1990; 1045:252–60.
12. Inui S, Fukuzato Y, Nakajima T et al. Identification of androgen-inducible TGF-β1 derived from dermal papilla cells as a key mediator in androgenetic alopecia. J Investig Dermatol Symp Proc 2003; 8:69–71.
13. Upton JH, Hannen RF, Bahta AW et al. Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia. J Invest Dermatol 2015; 135:1244–52.
14. Avci P, Gupta GK, Clark J et al. Low-level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg Med 2014; 46:144–51.