Alemtuzumab, Fludarabine, Low-Dose TBI, and Double Umbilical Cord Transplant for Primary Graft Failure in a Patient with Recurrent HLH

Pediatric Blood and Cancer

Volumn 63, Issue 2, 2016, Pages 361-363

  Hege, Kerry ^a   Quigg, Troy ^b   Delgado, David ^a  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b Pediatric Blood and Marrow Transplantation   (United States)

Author keywords

engraftment failure; hematopoietic stem cell transplantation; hemophagocytic lymphohistiocytosis; pediatric

Indexed keywords

ALEMTUZUMAB; CYCLOSPORIN; DEXAMETHASONE; ETOPOSIDE; FERRITIN; FLUDARABINE; INTERLEUKIN 2; RITUXIMAB;

ACUTE GRAFT VERSUS HOST DISEASE; ANEMIA; ARTICLE; BONE MARROW DISEASE; CANCER COMBINATION CHEMOTHERAPY; CANDIDEMIA; CASE REPORT; CORD BLOOD STEM CELL TRANSPLANTATION; EPSTEIN BARR VIRUS INFECTION; FEMALE; FERRITIN BLOOD LEVEL; FEVER; GRAFT FAILURE; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INFANT; LYMPHADENOPATHY; MALE; PRIORITY JOURNAL; RECURRENT DISEASE; THROMBOCYTOPENIA; VIREMIA; WHOLE BODY RADIATION;

EID: 85006263950     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.25782     Document Type: Article

References (20)

1. Chewning JH, Castro-Malaspina H, Jakubowski A, Kernan NA, Papadopoulos EB, Small TN, Heller G, Hsu KC, Perales MA, van den Brink MR, Young JW, Prockop SE, Collins NH, O'Reilly RJ, Boulad F. Fludarabine-based conditioning secures engraftment of second hematopoietic stem cell allografts (HSCT) in the treatment of initial graft failure. Biol Blood Marrow Transplant 2007;13:1313–1323.
2. Wolff SN. Second hematopoietic stem cell transplantation for the treatment of graft failure, graft rejection or relapse after allogeneic transplantation. Bone Marrow Transplant 2002;29:545–552.
3. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning. Blood 2003;102:1915–1919.
4. Narimatsu H, Kami M, Miyakoshi S, Murashige N, Yuji K, Hamaki T, Masuoka K, Kusumi E, Kishi Y, Matsumura T, Wake A, Morinaga S, Kanda Y, Taniguchi S. Graft failure following reduced-intensity cord blood transplantation for adult patients. Br J Haematol 2006;132:36–41.
5. Narimatsu H, Watanabe M, Kohno A, Sugimoto K, Kuwatsuka Y, Uchida T, Murata M, Miyamura K, Morishita Y, Nagoya Blood and Marrow Transplantation Group (NBMTG). High incidence of graft failure in unrelated cord blood transplantation using a reduced-intensity preparative regimen consisting of fludarabine and melphalan. Bone Marrow Transplant 2008;41:753–756.
6. Bradley MB, Satwani P, Baldinger L, Morris E, van den Ven C, Del Toro G, Garvin J, George D, Bhatia M, Roman E, Baxter-Lowe LA, Schwartz J, Qualter E, Hawks R, Wolownik K, Foley S, Militano O, Leclere J, Cheung YK, Cairo MS. Reduced intensity allogeneic umbilical cord blood transplantation in children and adolescent recipients with malignant and non-malignant diseases. Bone Marrow Transplant 2007;40:621–31.
7. Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S. Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis. Am J Hematol 2012;87:637–639.
8. Ouachee-Chardin M, Elie C, de Saint Basile G, Le Deist F, Mahlaoui N, Picard C, Neven B, Casanova JL, Tardieu M, Cavazzana-Calvo M, Blanche S, Fischer A. Hematopoietic stem cell transplantation in hemophagocytic lymphohistiocytosis: A single-center report of 48 patients. Pediatrics 2006;117:e743–e750.
9. Marsh RA, Jordan MB, Filipovich AH. Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: An important step forward. Br J Haematol 2011;154:556–563.
10. Schriber J, Agovi MA, Ho V, Ballen KK, Bacigalupo A, Lazarus HM, Bredeson CN, Gupta V, Maziarz RT, Hale GA, Litzow MR, Logan B, Bornhauser M, Giller RH, Isola L, Marks DI, Rizzo JD, Pasquini MC. Second unrelated donor hematopoietic cell transplantation for primary graft failure. Biol Blood Marrow Transplant 2010;16:1099–1106.
11. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007;48:124–131.
12. Chan KW, Grimley MS, Taylor C, Wall DA. Early identification and management of graft failure after unrelated cord blood transplantation. Bone Marrow Transplant 2008;42:35–41.
13. Fernandes J, Rocha V, Robin M, de Latour RP, Traineau R, Devergie A, Ribaud P, Rea D, Larghero J, Gluckman E, Socie G. Second transplant with two unrelated cord blood units for early graft failure after haematopoietic stem cell transplantation. Br J Haematol 2007;137:248–251.
14. Mizutani E, Narimatsu H, Murata M, Tomita A, Kiyoi H, Naoe T. Successful second cord blood transplantation using fludarabine and cyclophosphamide as a preparative regimen for graft rejection following reduced-intensity cord blood transplantation. Bone Marrow Transplant 2007;40:85–87.
15. Ohwada C, Nakaseko C, Ozawa S, Takeuchi M, Shono K, Koizumi M, Sakaida E, Cho R, Saito Y, Nishimura M. Second cord blood transplantation (CBT) with reduced-intensity conditioning for graft failure after the first CBT for AML. Bone Marrow Transplant 2004;34:999–1000.
16. Shimada K, Narimatsu H, Morishita Y, Kohno A, Saito S, Kato Y. Severe regimen-related toxicity of second transplantation for graft failure following reduced-intensity cord blood transplantation in an adult patient. Bone Marrow Transplant 2006;37:787–788.
17. Tanaka H, Ohwada C, Sakaida E, Takeda Y, Abe D, Oda K, Ozawa S, Shimizu N, Masuda S, Cho R, Nishimura M, Saito Y, Nakaseko C. Successful engraftment by second cord blood transplantation with reduced-intensity conditioning after graft rejection due to hemophagocytic syndrome following initial CBT. Bone Marrow Transplantation 2007;40:995–996.
18. Gyurkocza B, Cao TM, Storb RF, Lange T, Leisenring W, Franke GN, Sorror M, Hoppe R, Maloney DG, Negrin RS, Shizuru JA, Sandmaier BM. Salvage allogeneic hematopoietic cell transplantation with fludarabine and low-dose total body irradiation after rejection of first allografts. Biol Blood Marrow Transplant 2009;15:1314–1322.
19. Sumi M, Shimizu I, Sato K, Ueki T, Akahane D, Ueno M, Ichikawa N, Nakao S, Kobayashi H. Graft failure in cord blood transplantation successfully treated with short-term reduced-intensity conditioning regimen and second allogeneic transplantation. Int J Hematol 2010;92:744–750.
20. Ahmed N, Leung KS, Rosenblatt H, Bollard CM, Gottschalk S, Myers GD, Carrum G, Heslop HE, Brenner MK, Krance RA. Successful treatment of stem cell graft failure in pediatric patients using a submyeloablative regimen of campath-1H and fludarabine. Biol Blood Marrow Transplant 2008;14:1298–304.