Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin

ChemMedChem

Volumn 9, Issue 10, 2014, Pages 2223-2226

  Huang, Yijun ^a   Reis, Edimara S ^a   Knerr, Patrick J ^a   van der Donk, Wilfred A ^a   Ricklin, Daniel ^a   Lambris, John D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

albumin binding; complement inhibitor; compstatin; conjugation; peptide drugs

Indexed keywords

ALBUMINOID; COMPLEMENT INHIBITOR; COMPSTATIN; CYCLOPEPTIDE; PROTEIN BINDING;

AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; MOLECULAR GENETICS;

ALBUMINS; AMINO ACID SEQUENCE; COMPLEMENT INACTIVATING AGENTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN BINDING;

EID: 85006257588     PISSN: None     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201402212     Document Type: Article

References (0)