Acase of adenovirus viremia in a pediatric liver transplant recipientwith neutropenia and lymphopenia: Who and when shouldwe treat?

Journal of the Pediatric Infectious Diseases Society

Volumn 4, Issue 1, 2015, Pages e1-e5

  Patel, R R ^a   Hodinka, R L ^a,b   Kajon, A E ^c   Klieger, S ^a   Oikonomopoulou, Z ^a   Petersen, H ^c   Rand, E ^a   Attiyeh, E F ^a   Fisher, B T ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Adenovirus; Cidofovir; Orthotopic liver transplant

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPOFUNGIN; CEFTAZIDIME; CISPLATIN; DOXORUBICIN; FLUOROURACIL; GRANULOCYTE COLONY STIMULATING FACTOR; MEROPENEM; PREDNISONE; TACROLIMUS; VANCOMYCIN; VINCRISTINE; IMMUNOSUPPRESSIVE AGENT;

ADENOVIRIDAE; ARTICLE; CASE REPORT; CHILD; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DIARRHEA; DRUG DOSE INCREASE; FECES ANALYSIS; FEVER; GENE AMPLIFICATION; GENE SEQUENCE; HEMATOLOGICAL PARAMETERS; HEPATOBLASTOMA; HUMAN; LIVER TRANSPLANTATION; LYMPHOCYTOPENIA; MALE; NEUTROPENIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; VIREMIA; ADENOVIRUS INFECTIONS, HUMAN; COMPLICATION; HUMAN ADENOVIRUS C; IMMUNOCOMPROMISED PATIENT; LIVER NEOPLASMS; LYMPHOPENIA; METABOLISM; PHYSIOLOGY; VIROLOGY; VIRUS LOAD;

ADENOVIRUS INFECTIONS, HUMAN; ADENOVIRUSES, HUMAN; CHILD, PRESCHOOL; HEPATOBLASTOMA; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; LYMPHOPENIA; MALE; NEUTROPENIA; VIRAL LOAD; VIREMIA;

EID: 85006230914     PISSN: 20487193     EISSN: 20487207     Source Type: Journal    
DOI: 10.1093/jpids/pit081     Document Type: Article

References (18)

1. Hoffman JA. Adenovirus infections in solid organ transplant recipients.Curr Opin Organ Transplant 2009; 14:625-33
2. Ison MG, Green M, the AST Infectious Diseases Community ofPractice. Adenovirus in solid organ transplant recipients. Am JTransplant 2009; 9:S161-5
3. Michaels MG, Green M, Wald ER, Starzl TE. Adenovirus infectionin pediatric liver transplant recipients. J Infect Dis 1992;165:170-4
4. Hoffman JA. Adenoviral disease in pediatric solid organ transplantrecipients. Pediatr Transplant 2006; 10:17-25
5. TebrueggeM, Curtis N. Adenovirus: an overview for pediatric infectiousdiseases specialists. Pediatr Infect Dis J 2012; 31:626-7
6. Ljungman P, Ribaud P, Eyrich M, et al. Cidofovir for adenovirusinfections after allogeneic hematopoietic stem cell transplantation:a survey by the Infectious Diseases Working Party of theEuropean Group for Blood and Marrow Transplantation. BoneMarrow Transplant 2003; 31:481-6
7. Kajon AE, Erdman DD. Assessment of genetic variability amongsubspecies b1 human adenoviruses for molecular epidemiologystudies. Methods Mol Med 2007; 131:335-55
8. Hough R, Chetwood A, Sinfield R, et al. Fatal adenovirus hepatitisduring standard chemotherapy for childhood acute lymphoblasticleukemia. J Pediatr Hematol Oncol 2005; 27:67-72
9. Mateos ME, López-Laso E, Pérez-Navero JL, et al. Successful responseto cidofovir of adenovirus hepatitis during chemotherapyin a child with hepatoblastoma. J Pediatr Hematol Oncol 2012;34:e298-300
10. Leruez-Ville M, Minard V, Lacaille F, et al. Real-time bloodplasma polymerase chain reaction for management of disseminatedadenovirus infection. Clin Infect Dis 2004; 38:45-52
11. Cimsit B, Tichy EM, Patel SB, et al. Treatment of adenovirus hepatitiswith cidofovir in a pediatric liver transplant recipient.Pediatr Transplant 2012; 16:E90-3
12. Walls T, Hawrami K, Ushiro-Lumb I, et al. Adenovirus infectionafter pediatric bone marrow transplantation: is treatment alwaysnecessary? Clin Infect Dis 2005; 40:1244-9
13. Seidemann K, Heim A, Pfister ED, et al. Monitoring ofadenovirus infection in pediatric transplant recipients by quantitativePCR: report of six cases and review of the literature.Am J Transplant 2004; 4:2102-8
14. Engelmann G, Heim A, Greil J, et al. Adenovirus infection andtreatment with cidofovir in children after liver transplantation.Pediatr Transplant 2009; 13:421-8
15. Florescu DF, Hoffman JA, the AST Infectious DiseasesCommunity of Practice. Adenovirus in solid organ transplantation.Am J Transplant 2013; 13:206-11
16. Paolino K, Sande J, Perez E, et al. Eradication of disseminatedadenovirus infection in a pediatric hematopoietic stem celltransplantation recipient using the novel antiviral agentCMX001. J Clin Virol 2011; 50:167-70
17. Painter W, Robertson A, Trost LC, et al. First pharmacokineticand safety study in humans of the novel lipid antiviral conjugateCMX001, a broad spectrum oral drug active against double-strandedDNAviruses. Antimicrob Agents Chemother 2012; 56:2726-34
18. Lanier R, Trost L, Tippin T, et al. Development of CMX001 forthe treatment of poxvirus treatment. Viruses 2010; 2:2740-62.