Effect of PCSK9 inhibition by alirocumab on lipoprotein particle concentrations determined by nuclear magnetic resonance spectroscopy

Journal of the American Heart Association

Volumn 4, Issue 11, 2015, Pages

  Koren, Michael J ^a   Kereiakes, Dean ^b   Pourfarzib, Ray ^c   Winegar, Deborah ^d   Banerjee, Poulabi ^e   Hamon, Sara ^e   Hanotin, Corinne ^f   McKenney, James M ^g  

^a Jacksonville Center for Clinical Research   (United States)

^b The Carl & Edyth Lindner Center for Research & Education   (United States)

^c Alexion   (United States)

^d LABORATORY CORPORATION OF AMERICA   (United States)

^e REGENERON PHARMACEUTICALS INC   (United States)

^f SANOFI   (France)

^g National Clinical Research Inc   (United States)

Author keywords

Alirocumab; Lipoprotein particle number; Lipoprotein subfractions; Nuclear magnetic resonance spectroscopy; Proprotein convertase subtilisin kexin type 9 inhibitor

Indexed keywords

ALIROCUMAB; ATORVASTATIN; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; ANTILIPEMIC AGENT; BIOLOGICAL MARKER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 9; SERINE PROTEINASE INHIBITOR;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; DRUG WITHDRAWAL; ENZYME INHIBITION; FATIGUE; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; INJECTION SITE REACTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ANTAGONISTS AND INHIBITORS; BLOOD; CLINICAL TRIAL; COMBINATION DRUG THERAPY; ENZYMOLOGY; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE; PHASE 2 CLINICAL TRIAL; TREATMENT OUTCOME;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ATORVASTATIN CALCIUM; BIOMARKERS; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; HYPOLIPIDEMIC AGENTS; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARTICLE SIZE; PROPROTEIN CONVERTASE 9; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; TREATMENT OUTCOME;

EID: 85006201116     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002224     Document Type: Article

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