Low expression of CXCR1/2 on neutrophils predicts poor survival in patients with hepatitis B virus-related acute-on-chronic liver failure

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Xu, Ruonan ^a   Bao, Chunmei ^a   Huang, Huihuang ^a   Lin, Fang ^a   Yuan, Yue ^a   Wang, Siyu ^a   Jin, Lei ^a   Yang, Tao ^a   Shi, Ming ^a   Zhang, Zheng ^a   Wang, Fu Sheng ^a  

^a BEIJING 302 HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; IL8 PROTEIN, HUMAN; INTERLEUKIN 8;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; BLOOD; CLINICAL TRIAL; DISEASE FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION; HEPATITIS B; HUMAN; MALE; METABOLISM; MIDDLE AGED; MORTALITY; NEUTROPHIL; SURVIVAL RATE;

ACUTE-ON-CHRONIC LIVER FAILURE; ADULT; BIOMARKERS; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION; HEPATITIS B; HUMANS; INTERLEUKIN-8; MALE; MIDDLE AGED; NEUTROPHILS; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; SURVIVAL RATE;

EID: 85006094470     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep38714     Document Type: Article

References (21)

1. Wang, F. S. & Zhang, Z. Liver: How can acute-on-chronic liver failure be accurately identified? Nat Rev Gastroenterol Hepatol 10, 390-391 (2013).
2. Sarin, S. K. et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL). Hepatol Int 3, 269-282 (2009).
3. Mookerjee, R. P. et al. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology 46, 831-840 (2007).
4. Holmes, W. E. et al. Structure and functional expression of a human interleukin-8 receptor. Science 253, 1278-1280 (1991).
5. Pease, J. E. et al. The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Crit Care Med 1, 19-25 (2002).
6. Cummings, C. J. et al. Expression and Function of the Chemokine Receptors CXCR1 and CXCR2 in Sepsis. J Immunol 162, 2341-2346 (1999).
7. Singh, S. et al. CXCR1 and CXCR2 enhances human melanoma tunourigenesis growth and invasion. Br J Cancer 100, 1638-1646 (2009).
8. Sarin, S. K. et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int 8, 453-471 (2014).
9. Mookerjee, R. P. et al. Neutrophil Dysfunction in Alcoholic Hepatitis Superimposed on Cirrhosis is Reversible and Predicts the Outcome. Hepatology 46, 831-840 (2007)
10. Garg, V. et al. Granulocyte Colony-Stimulating Factor Mobilizes CD34+ Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure. Gastroenterology 142, 505-521 (2012).
11. Duan, X. Z. et al. Granulocyte-colony stimulating factor therapy improves survival in patients with hepatitis B virus-associated acuteon-chronic liver failure. World J Gastroenterol 19, 1104-1110 (2013).
12. Zapater, P. et al. Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis. Hepatology 48, 1924-1931 (2008)
13. Hartl, D. et al. Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Nat Med 13, 1423-1430 (2007).
14. Jaeschke, H. et al. Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress. Hepatology 29, 443-450 (1999)
15. Liu, Z. X. et al. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology 43, 1220-1230 (2006).
16. Lawson, J. A. et al. The hepatic inflammatory response after acetaminophen overdose: role of neutrophils. Toxicol Sci 54, 509-516 (2000).
17. Khandaker, M. H. et al. CXCR1 and CXCR2 Are Rapidly Down-Modulated by Bacterial Endotoxin Through a Unique Agonist-Independent, Tyrosine Kinase-Dependent Mechanism. J Immunol 161, 1930-1938 (1998).
18. Ahuja, S. K. et al. The CXC chemokines growth-regulated oncogene (GRO)-a, GRO-b, GRO-g, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor. J Biochem 271, 20545-20550 (1996).
19. Omari, K. M. et al. CXC chemokine receptors on human oligodendrocytes: implication for multiple sclerosis. Brain 128, 1003-10015 (2005).
20. Xu, D. et al. Circulating and liver resident CD4 + CD25+ regulatory T cells actively influence the antiviral immune response and disease progession in patients with hepatitis B. J Immunol 177, 739-747 (2006).
21. Zhang, Z. et al. Increased infiltration of intrahepatic DC subsets closely correlate with viral control and liver injury in immune active pediatric patients with chronic hepatitis B. Clin Immunol 122, 173-180 (2007).