Frailty is common and strongly associated with dyspnoea severity in fibrotic interstitial lung disease

Respirology

Volumn 22, Issue 4, 2017, Pages 728-734

  Milne, Kathryn M ^a   Kwan, Joanne M ^a   Guler, Sabina ^b   Winstone, Tiffany A ^a   Le, Angela ^a   Khalil, Nasreen ^a   Camp, Pat G ^a   Wilcox, Pearce G ^a   Ryerson, Christopher J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

dyspnoea; frailty; idiopathic pulmonary fibrosis; interstitial lung disease; outcomes

Indexed keywords

AGED; ARTICLE; COMPOSITE PHYSIOLOGIC INDEX; DISEASE SEVERITY; DYSPNEA; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; FRAILTY; FRAILTY INDEX; FUNCTIONAL ASSESSMENT; HUMAN; ILD GAP INDEX; INTERSTITIAL LUNG DISEASE; LUNG DIFFUSION CAPACITY; MAJOR CLINICAL STUDY; MALE; RESPIRATORY TRACT DISEASE ASSESSMENT; UNIVERSITY OF CALIFORNIA SAN DIEGO SHORTNESS OF BREATH QUESTIONNAIRE; ADULT; COMORBIDITY; FRAIL ELDERLY; LUNG; LUNG DISEASES, INTERSTITIAL; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PREVALENCE; QUESTIONNAIRE;

ADULT; AGED; COMORBIDITY; DYSPNEA; FEMALE; FORCED EXPIRATORY VOLUME; FRAIL ELDERLY; HUMANS; LUNG; LUNG DISEASES, INTERSTITIAL; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREVALENCE; SURVEYS AND QUESTIONNAIRES;

EID: 85006069958     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12944     Document Type: Article

References (39)

1. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA et al.; ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am. J. Respir. Crit. Care Med. 2011; 183: 788–824.
2. Travis WD, Costabel U, Hansell DM, King TE, Jr, Lynch DA, Nicholson AG, Ryerson CJ, Ryu JH, Selman M, Wells AU et al.; ATS/ERS Committee on Idiopathic Interstitial Pneumonias. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am. J. Respir. Crit. Care Med. 2013; 188: 733–48.
3. Ley B, Ryerson CJ, Vittinghoff E, Ryu JH, Tomassetti S, Lee JS, Poletti V, Buccioli M, Elicker BM, Jones KD et al. A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann. Intern. Med. 2012; 156: 684–91.
4. Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE Jr et al. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest 2014; 145: 723–8.
5. Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin. Geriatr. Med. 2011; 27: 17–26.
6. Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ 2011; 183: E487–94.
7. Kelaiditi E, Andrieu S, Cantet C, Vellas B, Cesari M ICTUS/DSA Group. Frailty index and incident mortality, hospitalization, and institutionalization in Alzheimer's disease: data from the ICTUS study. J. Gerontol. A: Biol. Sci. Med. Sci. 2015; 71: 543–8.
8. Guaraldi G, Brothers TD, Zona S, Stentarelli C, Carli F, Malagoli A, Santoro A, Menozzi M, Mussi C, Mussini C et al. A frailty index predicts survival and incident multimorbidity independent of markers of HIV disease severity. AIDS 2015; 29: 1633–41.
9. Rockwood MR, MacDonald E, Sutton E, Rockwood K, Baron M Canadian Scleroderma Research Group. Frailty index to measure health status in people with systemic sclerosis. J. Rheumatol. 2014; 41: 698–705.
10. Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008; 8: 24.
11. Song X, Mitnitski A, Rockwood K. Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. J. Am. Geriatr. Soc. 2010; 58: 681–7.
12. Ravindrarajah R, Lee DM, Pye SR, Gielen E, Boonen S, Vanderschueren D, Pendleton N, Finn JD, Tajar A, O'Connell MD et al.; European Male Aging Study Group. The ability of three different models of frailty to predict all-cause mortality: results from the European Male Aging Study (EMAS). Arch. Gerontol. Geriatr. 2013; 57: 360–8.
13. Saum KU, Dieffenbach AK, Muller H, Holleczek B, Hauer K, Brenner H. Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study. Eur. J. Epidemiol. 2014; 29: 171–9.
14. Singer JP, Diamond JM, Gries CJ, McDonnough J, Blanc PD, Shah R, Dean MY, Hersh B, Wolters PJ, Tokman S et al. Frailty phenotypes, disability, and outcomes in adult candidates for lung transplantation. Am. J. Respir. Crit. Care Med. 2015; 192: 1325–34.
15. Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE Jr, Koth LL, Lee JS et al. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax 2016; 71: 951–4.
16. Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE Jr, Wolters PJ et al. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur. Respir. J. 2013; 42: 750–7.
17. Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal 2001; 1: 323–36.
18. Hoover M, Rotermann M, Sanmartin C, Bernier J. Validation of an index to estimate the prevalence of frailty among community-dwelling seniors. Health Rep. 2013; 24: 10–7.
19. Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur. Respir. J. 2005; 26: 720–35.
20. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P et al. Standardisation of spirometry. Eur. Respir. J. 2005; 26: 319–38.
21. Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CP et al. Standardisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26: 511–22.
22. Holland AE, Spruit MA, Troosters T, Puhan MA, Pepin V, Saey D, McCormack MC, Carlin BW, Sciurba FC, Pitta F et al. An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur. Respir. J. 2014; 44: 1428–46.
23. Eakin EG, Resnikoff PM, Prewitt LM, Ries AL, Kaplan RM. Validation of a new dyspnea measure: the UCSD Shortness of Breath Questionnaire. University of California, San Diego. Chest 1998; 113: 619–24.
24. Wells AU, Desai SR, Rubens MB, Goh NS, Cramer D, Nicholson AG, Colby TV, du Bois RM, Hansell DM. Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography. Am. J. Respir. Crit. Care Med. 2003; 167: 962–9.
25. Nunnally JC, Bernstein IH. Psychometric Theory, 3rd edn. New York, McGraw-Hill, 1994.
26. Evans SJ, Sayers M, Mitnitski A, Rockwood K. The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing 2014; 43: 127–32.
27. Widagdo IS, Pratt N, Russell M, Roughead EE. Predictive performance of four frailty measures in an older Australian population. Age Ageing 2015; 44: 967–72.
28. Park SK, Richardson CR, Holleman RG, Larson JL. Frailty in people with COPD, using the National Health and Nutrition Evaluation Survey dataset (2003–2006). Heart Lung 2013; 42: 163–70.
29. du Bois RM, Weycker D, Albera C, Bradford WZ, Costabel U, Kartashov A, Lancaster L, Noble PW, Raghu G, Sahn SA et al. Ascertainment of individual risk of mortality for patients with idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2011; 184: 459–66.
30. Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E, Orwoll ES Osteoporotic Fractures in Men Research Group. Frailty in older men: prevalence, progression, and relationship with mortality. J. Am. Geriatr. Soc. 2007; 55: 1216–23.
31. Galizia G, Cacciatore F, Testa G, Della-Morte D, Mazzella F, Langellotto A, Raucci C, Gargiulo G, Ferrara N, Rengo F et al. Role of clinical frailty on long-term mortality of elderly subjects with and without chronic obstructive pulmonary disease. Aging Clin. Exp. Res. 2011; 23: 118–25.
32. Cacciatore F, Abete P, Mazzella F, Viati L, Della Morte D, D'Ambrosio D, Gargiulo G, Testa G, Santis D, Galizia G et al. Frailty predicts long-term mortality in elderly subjects with chronic heart failure. Eur. J. Clin. Invest. 2005; 35: 723–30.
33. McNallan SM, Chamberlain AM, Gerber Y, Singh M, Kane RL, Weston SA, Dunlay SM, Jiang R, Roger VL. Measuring frailty in heart failure: a community perspective. Am. Heart J. 2013; 166: 768–74.
34. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, Mitnitski A. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005; 173: 489–95.
35. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet 2013; 381: 752–62.
36. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G et al.; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J. Gerontol. A: Biol. Sci. Med. Sci. 2001; 56: M146–56.
37. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J. Gerontol. 1994; 49: M85–94.
38. Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing 2006; 35: 526–9.
39. Kulminski AM, Ukraintseva SV, Kulminskaya IV, Arbeev KG, Land K, Yashin AI. Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. J. Am. Geriatr. Soc. 2008; 56: 898–903.