Identification of small molecule modulators of MicroRNA by library screening

Methods in Molecular Biology

Volumn 1517, Issue , 2017, Pages 169-178

  Xiao, Zhangang ^a   Chen, Yangchao ^a,b  

^a Prince of Wales Hospital   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cancer; Library screening; MicroRNA; Small molecule

Indexed keywords

MICRORNA 34A; ANTINEOPLASTIC AGENT; LUCIFERASE; MICRORNA;

CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MOLECULAR LIBRARY; MOLECULAR WEIGHT; VALIDATION STUDY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MOLECULAR BIOLOGY; NEOPLASM; PROCEDURES; REPORTER GENE; THERAPEUTIC USE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; LUCIFERASES; MICRORNAS; MOLECULAR BIOLOGY; NEOPLASMS; SMALL MOLECULE LIBRARIES;

EID: 85005976051     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-6563-2_12     Document Type: Chapter

References (13)

1. Carthew RW (2006) Gene regulation by microRNAs. Curr Opin Genet Dev 16:203-208
2. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15-20
3. Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455:58-63
4. Hwang HW, Mendell JT (2007) MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 96(Suppl):40-44
5. Kuentz MT, Arnold Y (2009) Influence of molecular properties on oral bioavailability of lipophilic drugs -mapping of bulkiness and different measures of polarity. Pharm Dev Technol 14:312-320
6. Kim HY, Park JW (2014) Clinical trials of combined molecular targeted therapy and locoregional therapy in hepatocellular carcinoma: past, present, and future. Liver Cancer 3:9-17
7. Welch C, Chen Y, Stallings RL (2007) MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26:5017-5022
8. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER (2007) p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17:1298-1307
9. Yamakuchi M, Ferlito M, Lowenstein CJ (2008) miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A105:13421-13426
10. Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, Meister G, Hermeking H (2007) Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6:1586-1593
11. Xiao Z, Li CH, Chan SL, Xu F, Feng L, Wang Y, Jiang JD, Sung JJ, Cheng CH, Chen Y (2014) A small-molecule modulator of the tumor-suppressor miR34a inhibits the growth of hepatocellular carcinoma. Cancer Res 74:6236-6247
12. Gumireddy K, Young DD, Xiong X, Hogenesch JB, Huang Q, Deiters A (2008) Smallmolecule inhibitors of microrna miR-21 function. Angew Chem Int Ed Engl 47:7482-7484
13. Young DD, Connelly CM, Grohmann C, Deiters A (2010) Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma. J Am Chem Soc 132:7976-7981