Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

Multiple Sclerosis

Volumn 22, Issue 14, 2016, Pages 1883-1887

  Zinger, Anna ^a   Latham, Sharissa L ^a   Combes, Valery ^a   Byrne, Scott ^a   Barnett, Michael H ^b   Hawke, Simon ^a,b,c   Grau, Georges E ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c Central West Neurology and Neurosurgery   (Australia)

Author keywords

B cells; biological marker; fingolimod; immunology; Multiple sclerosis; plasma microparticles; vascular endothelium

Indexed keywords

BIOLOGICAL MARKER; FINGOLIMOD; TUMOR NECROSIS FACTOR; IMMUNOSUPPRESSIVE AGENT;

ADULT; ARTICLE; B LYMPHOCYTE DERIVED MICROPARTICLE; CELL FUNCTION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIAL MICROPARTICLE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE COUNT; MALE; MEMBRANE MICROPARTICLE; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; TREATMENT DURATION; B LYMPHOCYTE; BLOOD; DRUG EFFECTS; ENDOTHELIUM CELL; MIDDLE AGED; VASCULAR ENDOTHELIUM;

ADULT; B-LYMPHOCYTES; CELL-DERIVED MICROPARTICLES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FEMALE; FINGOLIMOD HYDROCHLORIDE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS;

EID: 85005870097     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458516636959     Document Type: Article

References (13)

1. Combes V, Simon AC, Grau GE, et al. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J Clin Invest 1999; 104: 93-102.
2. Chofflon M, Roth S, Juillard C, et al. Tumor necrosis factor production capacity as a potentially useful parameter to monitor disease activity in multiple sclerosis. Eur Cytokine Netw 1997; 8: 253-257.
3. Schindler SM, Little JP, Klegeris A,. Microparticles: A new perspective in central nervous system disorders. Biomed Res Int 2014; 2014: 756327.
4. Minagar A, Jy W, Jimenez JJ, et al. Elevated plasma endothelial microparticles in multiple sclerosis. Neurology 2001; 56: 1319-1324.
5. Marcos-Ramiro B, Oliva Nacarino P, Serrano-Pertierra E, et al. Microparticles in multiple sclerosis and clinically isolated syndrome: Effect on endothelial barrier function. BMC Neurosci 2014; 15: 110.
6. Jy W, Minagar A, Jimenez JJ, et al. Endothelial microparticles (EMP) bind and activate monocytes: Elevated EMP-monocyte conjugates in multiple sclerosis. Front Biosci 2004; 9: 3137-3144.
7. Jimenez J, Jy W, Mauro LM, et al. Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes. Mult Scler 2005; 11: 310-315.
8. Pankoui Mfonkeu JB, Gouado I, Fotso Kuate H, et al. Elevated cell-specific microparticles are a biological marker for cerebral dysfunctions in human severe malaria. PLoS ONE 2010; 5: e13415.
9. Latham SL, Tiberti N, Gokoolparsadh N, et al. Immuno-analysis of microparticles: Probing at the limits of detection. Sci Rep 2015; 5: 16314.
10. Latham SL, Chaponnier C, Dugina V, et al. Cooperation between beta- and gamma-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation. FASEB J 2013; 27: 672-683.
11. Alexander JS, Chervenak R, Weinstock-Guttman B, et al. Blood circulating microparticle species in relapsing-remitting and secondary progressive multiple sclerosis. A case-control, cross sectional study with conventional MRI and advanced iron content imaging outcomes. J Neurol Sci 2015; 355: 84-89.
12. Saenz-Cuesta M, Irizar H, Castillo-Trivino T, et al. Circulating microparticles reflect treatment effects and clinical status in multiple sclerosis. Biomark Med 2014; 8: 653-661.
13. Faille D, Combes V, Mitchell AJ, et al. Platelet microparticles: A new player in malaria parasite cytoadherence to human brain endothelium. FASEB J 2009; 23: 3449-3458.