D-cycloserine, an NMDA glutamate receptor glycine site partial agonist, induces acute increases in brain glutamate plus glutamine and GABA comparable to ketamine

American Journal of Psychiatry

Volumn 173, Issue 12, 2016, Pages 1241-1242

  Kantrowitz, Joshua T ^a   Milak, Matthew S ^a   Mao, Xiangling ^a   Shungu, Dikoma C ^a   Mann, J John ^a  

^a

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; CYCLOSERINE; GLUTAMIC ACID; GLUTAMINE; KETAMINE; AMINO ACID RECEPTOR STIMULATING AGENT;

DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG POTENCY; HUMAN; LETTER; LOW DRUG DOSE; MAJOR DEPRESSION; MEDIAL PREFRONTAL CORTEX; PRIORITY JOURNAL; BRAIN CHEMISTRY; DRUG EFFECTS; PROTON NUCLEAR MAGNETIC RESONANCE;

BRAIN CHEMISTRY; CYCLOSERINE; EXCITATORY AMINO ACID AGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; GLUTAMINE; HUMANS; KETAMINE; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 85002156911     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2016.16060735     Document Type: Letter

References (4)

1. Milak MS, Proper CJ, Mulhern ST, et al: A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder. Mol Psychiatry 2015; 21:320-327
2. Ren Z, Pribiag H, Jefferson SJ, et al: Bidirectional homeostatic regulation of a depression-related brain state by gamma-aminobutyric acidergic deficits and ketamine treatment. Biol Psychiatry 2016; 80: 457-468
3. Kantrowitz JT, Halberstam B, Gangwisch J: Single-dose ketamine followed by daily D-cycloserine in treatment-resistant bipolar depression. J Clin Psychiatry 2015; 76:737-738
4. Emmett MR, Mick SJ, Cler JA, et al: Actions of D-cycloserine at the N-methyl-D-aspartate-associated glycine receptor site in vivo. Neuropharmacology 1991; 30:1167-1171