Detection of vaccine-induced antibodies to Ebola virus in oral fluid

Open Forum Infectious Diseases

Volumn 3, Issue 1, 2016, Pages

  Lambe, Teresa ^a   Rampling, Tommy ^a   Samuel, Dhan ^b   Bowyer, Georgina ^a   Ewer, Katie J ^a   Venkatraman, Navin ^a   Edmans, Matthew ^a   Dicks, Steve ^c   Hill, Adrian V S ^a   Tedder, Richard S ^b   Gilbert, Sarah C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Antibodies; Ebola vaccine; Oral fluid; Serology

Indexed keywords

EBOLA VACCINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; VIRUS ANTIBODY; VIRUS GLYCOPROTEIN;

ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BLOOD SAMPLING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; HUMAN; IMMUNOGENICITY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; VACCINATION; VIRUS REPLICATION;

EID: 85000470452     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofw031     Document Type: Article

References (9)

1. Regules JA, Beigel JH, Paolino KM, et al. A recombinant vesicular stomatitis virus Ebola vaccine -preliminary report. N Engl J Med 2015; doi:10.1056/ NEJMoa1414216.
2. Henao-Restrepo AM, Longini IM, Egger M, et al. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial. Lancet 2015; 386: 857-66.
3. Ledgerwood JE, DeZure AD, Stanley DA, et al. Chimpanzee adenovirus vector Ebola vaccine -preliminary report. N Engl J Med 2014; doi:10.1056/NEJMoa 1410863.
4. Rampling T, Ewer K, Bowyer G, et al. A monovalent chimpanzee adenovirus Ebola vaccine -preliminary report. N Engl J Med 2015; doi:10.1056/NEJMoa1411627.
5. Gilbert SC. Adenovirus-vectored Ebola vaccines. Expert Rev Vaccines 2015; 694:216-33.
6. Parry JV. Simple and reliable salivary tests for HIV and hepatitis A and B virus diagnosis and surveillance. Ann N Y Acad Sci 1993; 694:216-33.
7. Perry KR, Brown DW, Parry JV, et al. Detection of measles, mumps, and rubella antibodies in saliva using antibody capture radioimmunoassay. J Med Virol 1993; 40:235-40.
8. Medical training video: oral fluid samples. Available at: https://www.youtube.com/ watch?v=6wDDLp_OaTc. Accessed 1 September 2015.
9. Miura K, Orcutt AC, Muratova OV, et al. Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines. Vaccine 2008; 26: 193-200.