Burden of nursing home-onset Clostridium diffficile infection in the United States: Estimates of incidence and patient outcomes

Open Forum Infectious Diseases

Volumn 3, Issue 1, 2016, Pages

  Hunter, Jennifer C ^a,b   Mu, Yi ^a   Dumyati, Ghinwa K ^c   Farley, Monica M ^d,e   Winston, Lisa G ^f   Johnston, Helen L ^g   Meek, James I ^h   Perlmutter, Rebecca ⁱ   Holzbauer, Stacy M ^b,j   Beldavs, Zintars G ^k   Phipps, Erin C ^l   Dunn, John R ^m   Cohen, Jessica A ^a,n   Avillan, Johannetsy ^a   Stone, Nimalie D ^a   Gerding, Dale N ^o,p   McDonald, L Clifford ^a   Lessa, Fernanda C ^a  

^a NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ATLANTA VA MEDICAL CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g Air Pollution Control Division   (United States)

^h YALE UNIVERSITY   (United States)

ⁱ MARYLAND DEPARTMENT OF HEALTH AND MENTAL HYGIENE   (United States)

^j MINNESOTA DEPARTMENT OF HEALTH   (United States)

^k OREGON HEALTH AUTHORITY   (United States)

^l UNIVERSITY OF NEW MEXICO   (United States)

^m TENNESSEE DEPARTMENT OF HEALTH   (United States)

ⁿ Atlanta Research and Education Foundation Inc   (United States)

^o LOYOLA UNIVERSITY CHICAGO   (United States)

^p VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

Clostridium difficile; Long term care facility; Nursing home

Indexed keywords

ANTIBIOTIC AGENT;

ADOLESCENT; ADULT; AGED; ANTIMICROBIAL THERAPY; ARTICLE; CHILD; CLOSTRIDIUM DIFFICILE INFECTION; DEATH; FECES ANALYSIS; FEMALE; HOSPITALIZATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NURSING HOME; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; RECURRENT DISEASE; RISK FACTOR; TREATMENT OUTCOME; UNITED STATES; VERY ELDERLY;

EID: 85000461256     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofv196     Document Type: Article

References (35)

1. Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med 2014; 370:1198-208.
2. Centers for Disease Control and Prevention (CDC). Vital signs: preventing Clostridium difficile infections. MMWR Morb Mortal Wkly Rep 2012;61: "157-62.
3. US Centers for Disease Control and Prevention (CDC). Antibiotic resistance threats in the United States, 2013. Available at: http://www.cdc.gov/drugre sistance/threat-report-2013/index.html. Accessed 1 March 2014.
4. Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015; 372:825-34.
5. Simor AE. Diagnosis, management, and prevention of Clostridium difficile infec- tion in long-term care facilities: a review. N Engl J Med 2010; 58:1556-64.
6. Claesson MJ, Cusack S, O'Sullivan O, et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 2011; 108(Suppl 1):4586-91.
7. Henrich TJ, Krakower D, Bitton A, Yokoe DS. Clinical risk factors for severe Clos- tridium difficile-associated disease. Emerg Infect Dis 2009; 15:415-22.
8. Garey KW, Sethi S, Yadav Y, DuPont HL. Meta-analysis to assess risk factors for recurrent Clostridium difficile infection. J Hosp Infect 2008;70:298-304.
9. American Healthcare Association. 2013 Quality Report: ACHA, 2013.Avail- able at: http://www.ahcancal.org/qualityreport/Documents/AHCA_2013QR_ ONLINE.pdf. Accessed 1 March 2014.
10. Mody L, Bradley SF, Huang SS. Keeping the "home" in nursing home: implications for infection prevention. JAMA internal medicine 2013; 173:853-4.
11. Jones AL, Dwyer LL, Bercovitz AR, Strahan GW. The National Nursing Home Survey: 2004 overview. Vital Health Stat 13 2009;1-155.
12. Pawar D, Tsay R, Nelson DS, et al. Burden of Clostridium difficile infection in long- term care facilities in Monroe County, New York. Infect Control Hosp Epidemiol 2012; 33:1107-12.
13. Campbell RJ, Giljahn L, Machesky K, et al. Clostridium difficile infection in Ohio hospitals and nursing homes during 2006. Infect Control Hosp Epidemiol 2009; 30:526-33.
14. Kim JH, Toy D, Muder RR. Clostridium difficile infection in a long-term care fa- cility: hospital-associated illness compared with long-term care-associated illness. Infect Control Hosp Epidemiol 2011; 32:656-60.
15. Chopra T, Goldstein EJ. Clostridium difficile infection in long-term care facilities: a call to action for antimicrobial stewardship. Clin Infect Dis 2015;60(Suppl2): S72-6.
16. US Centers for Disease Control and Prevention (CDC). Measuring the Scope of Clostridium difficile Infection in the United States. Available at: http://www.cdc. gov/hai/eip/cdiff_techinfo.html. Accessed 1 March 2014.
17. Lessa FC, Mu Y, Winston L, et al. Determinants of Clostridium difficile infection incidence across diverse U.S. geographic locations. Open Forum Infect Dis 2014; 1(2):doi: 10.1093/ofid/ofu048.
18. Area Health Resources Files (AHRF). Rockville, MD: US Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Workforce 2012-2013. Available at: http://ahrf.hrsa.gov/. Accessed 1 March 2014.
19. Lowy I, Molrine DC, Leav BA, et al. Treatment withmonoclonal antibodies against Clostridium difficile toxins. N Engl J Med 2010; 362:197-205.
20. Fawley WN, Knetsch CW, MacCannell DR, et al. Development and validation of an internationally-standardized, high-resolution capillary gel-based electrophore- sis PCR-ribotyping protocol for Clostridium difficile. PLoSOne 2015;10: e0118150.
21. Dubberke ER, Butler AM, Reske KA, et al. Attributable outcomes of endemic Clos- tridium difficile-associated disease in nonsurgical patients. Emerg Infect Dis 2008; 14:1031-8.
22. US Centers forMedicare &Medicaid Services (CMS). Nursing Home Compendium 2013. Edition. Available at: https://www.cms.gov/Medicare/Provider-Enrollment- and-Certification/CertificationandComplianc/Downloads/nursinghomedata compendium_508.pdf. Accessed 1 March 2014.
23. Loo VG, Bourgault AM, Poirier L, et al. Host and pathogen factors for Clostridium difficile infection and colonization. N Engl J Med 2011; 365:1693-703.
24. McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 1989; 320:204-10.
25. Vardakas KZ, Konstantelias AA, Loizidis G, et al. Risk factors for development of Clostridium difficile infection due to BI/NAP1/027 strain: a meta-analysis. Int J In- fect Dis 2012; 16:e768-73.
26. Hensgens MP, Goorhuis A, Notermans DW, et al. Decrease of hypervirulent Clostridium difficile PCR ribotype 027 in the Netherlands. Euro Surveill 2009; 14:pii: 19402.
27. Wilcox MH, Shetty N, Fawley WN, et al. Changing epidemiology of Clostridium difficile infection following the introduction of a national ribotyping-based surveil- lance scheme in England. Clin Infect Dis 2012; 55:1056-63.
28. Bauer MP, Notermans DW, van Benthem BH, et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011; 377:63-73.
29. Keel K, Brazier JS, Post KW, et al. Prevalence of PCR ribotypes among Clostridium difficile isolates from pigs, calves, and other species. J Clin Microbiol 2007; 45:1963-4.
30. Davies KA, Longshaw CM, Davis GL, et al. Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EU- CLID). Lancet Infect Dis 2014; 14:1208-19.
31. Dubberke ER, Han Z, Bobo L, et al. Impact of clinical symptoms on interpretation of diagnostic assays for Clostridium difficile infections. J Clin Microbiol 2011; 49:2887-93.
32. Bouwknegt M, van Dorp S, Kuijper E. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015; 372:2368.
33. Banaei N, Anikst V, Schroeder LF. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015; 372:2368-9.
34. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostrid- ium difficile infection in adults: 2010 update by the Society for Healthcare Epide- miology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010; 31:431-55.
35. Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015; 372(suppl):S1-3.