Proof of concept of the preventive efficacy of high-dose recombinant mono-allergen immunotherapy in atopic dogs sensitized to the Dermatophagoides farinae allergen Der f 2

Veterinary Dermatology

Volumn 28, Issue 2, 2017, Pages 183-e40

  Olivry, Thierry ^a   Paps, Judy S ^a   Dunston, Stanley M ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTHROPOD PROTEIN; DERMATOPHAGOIDES FARINAE ANTIGEN F 2; HOUSE DUST ALLERGEN; RECOMBINANT PROTEIN;

ANIMAL; ATOPIC DERMATITIS; DESENSITIZATION; DOG; DOG DISEASE; DOSE RESPONSE; IMMUNOLOGY; INTRACUTANEOUS TEST; SKIN ABSORPTION; VETERINARY;

ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ARTHROPOD PROTEINS; DERMATITIS, ATOPIC; DESENSITIZATION, IMMUNOLOGIC; DOG DISEASES; DOGS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; INTRADERMAL TESTS; RECOMBINANT PROTEINS; SUBCUTANEOUS ABSORPTION;

EID: 85000398800     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/vde.12395     Document Type: Article

References (20)

1. Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 1998; 102: 558–562.
2. Jutel M, Agache I, Bonini S et al. International consensus on allergen immunotherapy II: mechanisms, standardization, and pharmacoeconomics. J Allergy Clin Immunol 2016; 137: 358–368.
3. Yamashita K, Fujiwara C, Azuma R et al. Determination of antigenic proteins of housedust mites in 90 dogs suffering from atopic dermatitis. J Vet Med Sci 2002; 64: 673–676.
4. Pucheu-Haston CM, Jackson HA, Olivry T et al. Epicutaneous sensitization with Dermatophagoides farinae induces generalized allergic dermatitis and elevated mite-specific immunoglobulin E levels in a canine model of atopic dermatitis. Clin Exp Allergy 2008; 38: 667–679.
5. Olivry T, Wofford J, Paps JS et al. Stratum corneum removal facilitates experimental sensitization to allergens in atopic dogs. Vet Dermatol 2011; 22: 188–196.
6. Bizikova P, Papich MG, Olivry T. Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. Vet Dermatol 2008; 19: 348–357.
7. Hammerberg B, Bevier D, DeBoer DJ et al. Auto IgG anti-IgE and IgG x IgE immune complex presence and effects on ELISA-based quantitation of IgE in canine atopic dermatitis, demodectic acariasis and helminthiasis. Vet Immunol Immunopathol 1997; 60: 33–46.
8. Griffin CE, Hillier A. The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy. Vet Immunol Immunopathol 2001; 81: 363–384.
9. Mueller RS, Fieseler KV, Zabel S et al. Conventional and rush allergen-specific immunotherapy in the treatment of canine atopic dermatitis. In: Hillier A, Foster AP, Kwochka KW, eds. Advances in veterinary dermatology, volume 5; Oxford, UK: Blackwell Publishing, 2005: 60–69.`
10. Haugaard L, Dahl R, Jacobsen L. A controlled dose-response study of immunotherapy with standardized, partially purified extract of house dust mite: clinical efficacy and side effects. J Allergy Clin Immunol 1993; 91: 709–722.
11. Olaguibel JM, Tabar AI, Garcia Figueroa BE et al. Immunotherapy with standardized extract of Dermatophagoides pteronyssinus in bronchial asthma: a dose-titration study. Allergy 1997; 52: 168–178.
12. Mehvar R. Recent trends in the use of polysaccharides for improved delivery of therapeutic agents: pharmacokinetic and pharmacodynamic perspectives. Curr Pharm Biotechnol 2003; 4: 283–302.
13. Noss I, Doekes G, Thorne PS et al. Comparison of the potency of a variety of beta-glucans to induce cytokine production in human whole blood. Innate Immun 2013; 19: 10–19.
14. Wang F, Qiao L, Chen L et al. The immunomodulatory activities of pullulan and its derivatives in human pDC-like CAL-1 cell line. Int J Biol Macromol 2016; 86: 764–771.
15. Zhang W, Yu X, Kwak M et al. Maturation of dendritic cells by pullulan promotes anti-cancer effect. Oncotarget 2016; doi: 10.18632/oncotarget.10183
16. Keppel KE, Campbell KL, Zuckermann FA et al. Quantitation of canine regulatory T cell populations, serum interleukin-10 and allergen-specific IgE concentrations in healthy control dogs and canine atopic dermatitis patients receiving allergen-specific immunotherapy. Vet Immunol Immunopathol 2008; 123: 337–344.
17. DeBoer DJ, Verbrugge M, Morris M. Clinical and immunological responses of dust mite sensitive, atopic dogs to treatment with sublingual immunotherapy (SLIT). Vet Dermatol 2016; 27: 82–7e23.
18. Marsella R. Tolerability and clinical efficacy of oral immunotherapy with house dust mites in a model of canine atopic dermatitis: a pilot study. Vet Dermatol 2010; 21: 566–571.
19. Yamaya S, Yamamoto A, Komiya T et al. Preparation of a diphtheria toxin-pullulan conjugate that elicits good IgG antibody production with poor IgE synthesis. Vaccine 1990; 8: 65–69.
20. Uchida T, Ikegami H, Ando S et al. Suppression of murine IgE responses with ovalbumin-pullulan conjugates: comparison of the suppressive effect of different conjugation methods and different molecular weights of pullulan. Int Arch Allergy Immunol 1993; 102: 276–278.