Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised Trial

PLoS Medicine

Volumn 13, Issue 11, 2016, Pages

  Cissé, Badara ^a,b   Ba, El Hadj ^b,c   Sokhna, Cheikh ^c   NDiaye, Jean Louis ^a   Gomis, Jules F ^a   Dial, Yankhoba ^d   Pitt, Catherine ^b   NDiaye, Mouhamed ^a   Cairns, Matthew ^b   Faye, Ernest ^a   NDiaye, Magatte ^a   Lo, Aminata ^a   Tine, Roger ^a   Faye, Sylvain ^a   Faye, Babacar ^a   Sy, Ousmane ^a   Konate, Lansana ^a   Kouevijdin, Ekoue ^c   Flach, Clare ^b   Faye, Ousmane ^a   Trape, Jean Francois ^c   Sutherland, Colin ^b   Fall, Fatou Ba ^d   Thior, Pape M ^d   Faye, Oumar K ^d   Greenwood, Brian ^b   Gaye, Oumar ^a   Milligan, Paul ^b   more..

^a UNIVERSITÉ CHEIKH ANTA DIOP   (Senegal)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (Senegal)

^d Centre Antipoison du Sénégal   (Senegal)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; DRUG COMBINATION; FANASIL, PYRIMETHAMINE DRUG COMBINATION; PYRIMETHAMINE; SULFADOXINE;

ACUTE DISEASE; ANEMIA; ARTICLE; CHEMOPROPHYLAXIS; CHILD; CLUSTER ANALYSIS; COST BENEFIT ANALYSIS; DNA POLYMORPHISM; FACE EDEMA; GENE SEQUENCE; HUMAN; INSECTICIDE TREATED NET; JAUNDICE; MALARIA; MEDICATION COMPLIANCE; MORTALITY RATE; PARASITEMIA; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RASH; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENEGAL; VOMITING; CONTROLLED STUDY; DRUG COMBINATION; INFANT; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SEASON; STANDARDS;

AMODIAQUINE; ANTIMALARIALS; CHEMOPREVENTION; CHILD; CHILD, PRESCHOOL; DRUG COMBINATIONS; HUMANS; INFANT; MALARIA; PYRIMETHAMINE; SEASONS; SENEGAL; SULFADOXINE;

EID: 84999836714     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002175     Document Type: Article

References (16)

1. World Health Organization (2012) WHO Policy Recommendation: Seasonal Malaria Chemoprevention (SMC) for Plasmodium falciparum malaria control in highly seasonal transmission areas of the Sahel sub-region in Africa. March 2012. (In English and French). http://www.who.int/malaria/publications/atoz/who_smc_policy_recommendation/en/index.html
2. World Health Organization (2011) Report of the Technical consultation on Seasonal Malaria Chemoprevention (SMC) Geneva 4–6 May 2011. http://www.who.int/malaria/publications/atoz/smc_report_teg_meetingmay2011/en/index.html
3. Cairns M, Roca-Feltrer A, Garske T, Wilson AL, Diallo D, Milligan PJM, et al. (2012) Estimating the potential public health impact of seasonal malaria chemoprevention in African children. Nat Commun, 3, 881. doi: 10.1038/ncomms187922673908
4. WHO (2012) Seasonal Malaria Chemoprevention with sulfadoxine-pyrimethamine plus amodiaquine in children. A Field Guide. November 2012. WHO:Geneva.
5. http://impact.ref.ac.uk/CaseStudies/CaseStudy.aspx?Id=41452
6. http://www.malariaconsortium.org/what-we-do/projects/41/access-smc
7. Okiro EA, Al-Taiar A, Reyburn H, Idro R, Berkley JA, Snow RW, (2009) Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. Malaria Journal8:4doi: 10.1186/1475-2875-8-419128453
8. Noor AM, Kibuchi E, Mitto B, Coulibaly D, Doumbo OK, Snow RW, (2015) Sub-National Targeting of Seasonal Malaria Chemoprevention in the Sahelian Countries of the Nouakchott Initiative. PLoS ONE10(8): e0136919. doi: 10.1371/journal.pone.013691926322634
9. NDiaye JL, Cissé B, Ba EH, Gomis JF, Ndour CT, Molez JF, et al. (2016) Safety of Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine when delivered to children under 10 years of age by district health services in Senegal. PLoS ONE11(10): e0162563. doi: 10.1371/journal.pone.016256327764102
10. Cisse B, Sokhna C, Boulanger D, Milet J, Ba EH, Richardson K, et al. (2006) Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial. The Lancet, 367, 659–667.
11. Sokhna C, Cisse B, Ba EH, Milligan P, Hallett R, Sutherland C, et al. (2008) A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment in Senegalese children. PLoS ONE3: e1471. doi: 10.1371/journal.pone.000147118213379
12. Brown CA, Lilford RJ, (2006) The stepped wedge trial design: a systematic review. BMC Medical Research Methodology6:54doi: 10.1186/1471-2288-6-5417092344
13. Heming K, Girling A, (2014) A menu-driven facility for power and detectable-difference calculations in stepped-wedge cluster-randomized trials. Stata Journal14(2):363–380.
14. Lo AC, Faye B, Ba EH, Cisse B, Tine R, Abiola A, et al. (2013) Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal. Malaria Journal12:137doi: 10.1186/1475-2875-12-13723617576
15. David Sinclair, Martin M Meremikwu, and Paul Garner (2012) Seasonal Malaria Chemoprevention for preventing malaria morbidity in children aged less than 5 years living in areas of marked seasonal transmission: GRADE tables to assist guideline development and recommendations—background document for inaugural MPAC meeting 2012. [http://www.who.int/malaria/mpac/feb2012/smc_grade_tables.pdf].
16. Trape J-F, Sauvage C, Ndiaye O, Douillot L, Marra A, Diallo A, et al. (2012) New Malaria-Control Policies and Child Mortality in Senegal: Reaching Millennium Development Goal 4. Journal of Infectious Diseases205:672–679doi: 10.1093/infdis/jir80522238469