Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

Nature Communications

Volumn 7, Issue , 2016, Pages

  Ungelenk, Sophia ^a,b   Moayed, Fatemeh ^c   Ho, Chi Ting ^a,b   Grousl, Tomas ^a,b   Scharf, Annette ^a   Mashaghi, Alireza ^c   Tans, Sander ^c   Mayer, Matthias P ^a   Mogk, Axel ^a,b   Bukau, Bernd ^a,b  

^a GERMAN CANCER RESEARCH CENTER   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c FOM INSTITUTE AMOLF   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; HEAT SHOCK PROTEIN 100; HEAT SHOCK PROTEIN 70; MALATE DEHYDROGENASE; SMALL HEAT SHOCK PROTEIN; SMALL HEAT SHOCK PROTEIN 26; SMALL HEAT SHOCK PROTEIN 42; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; HSP26 PROTEIN, S CEREVISIAE; HSP42 PROTEIN, S CEREVISIAE; PROTEIN AGGREGATE; SACCHAROMYCES CEREVISIAE PROTEIN;

AGGREGATION; CELLS AND CELL COMPONENTS; COMPARATIVE STUDY; EXPERIMENTAL STUDY; FITNESS; HEAT SHOCK; MOLECULAR ANALYSIS; PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL PROTECTION; COMPARATIVE STUDY; HEAT STRESS; IN VITRO STUDY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN MISFOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN REFOLDING; PROTEIN STABILITY; PROTEIN UNFOLDING; SACCHAROMYCES CEREVISIAE; HEAT SHOCK RESPONSE; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN FOLDING;

CYTOPROTECTION; HEAT-SHOCK PROTEINS; HEAT-SHOCK PROTEINS, SMALL; HEAT-SHOCK RESPONSE; HSP70 HEAT-SHOCK PROTEINS; MALATE DEHYDROGENASE; MUTATION; PROTEIN AGGREGATES; PROTEIN CONFORMATION; PROTEIN FOLDING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84999287036     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13673     Document Type: Article

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