Relation of Left Ventricular Mass and Infarct Size in Anterior Wall ST-Segment Elevation Acute Myocardial Infarction (from the EMBRACE STEMI Clinical Trial)

American Journal of Cardiology

Volumn 118, Issue 5, 2016, Pages 625-631

  Daaboul, Yazan ^a   Korjian, Serge ^a   Weaver, W Douglas ^b   Kloner, Robert A ^c,d   Giugliano, Robert P ^a   Carr, Jim ^e   Neal, Brandon J ^a   Chi, Gerald ^a   Cochet, Madeleine ^a   Goodell, Laura ^a   Michalak, Nathan ^a   Rusowicz Orazem, Luke ^a   Alkathery, Turky ^a   Allaham, Haytham ^a   Routray, Sujit ^a   Szlosek, Donald ^a   Jain, Purva ^a   Gibson, C Michael ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e Stealth BioTherapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE MB; ELAMIPRETIDE; PLACEBO; TROPONIN I; ANTIOXIDANT; ARGINYL-2,'6'-DIMETHYLTYROSYL-LYSYL-PHENYLALANINAMIDE; BIOLOGICAL MARKER; OLIGOPEPTIDE;

ADULT; AGE; ANTERIOR MYOCARDIAL INFARCTION; ARTERY OCCLUSION; ARTICLE; BODY MASS; BODY SURFACE; CARDIAC PATIENT; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSLIPIDEMIA; FEMALE; GENDER; HEART INFARCTION SIZE; HEART INJURY; HEART LEFT VENTRICLE MASS; HEART MUSCLE ISCHEMIA; HUMAN; HYPERTENSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MYOCARDIAL SALVAGE INDEX; PERCUTANEOUS CORONARY INTERVENTION; PHASE 2 CLINICAL TRIAL (TOPIC); POST HOC ANALYSIS; PRIORITY JOURNAL; RADIOCARDIOGRAPHY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPERFUSION INJURY; SMOKING; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THROMBUS ASPIRATION; TIME; AGED; ANTERIOR WALL MYOCARDIAL INFARCTION; BLOOD; CARDIAC MUSCLE; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; ENZYMOLOGY; HEART VENTRICLE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHASE 2 CLINICAL TRIAL; PREDICTIVE VALUE; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY AND SPECIFICITY; ST ELEVATION MYOCARDIAL INFARCTION; TIME FACTOR; TREATMENT OUTCOME;

AGED; ANTERIOR WALL MYOCARDIAL INFARCTION; ANTIOXIDANTS; BIOMARKERS; CREATINE KINASE, MB FORM; DOUBLE-BLIND METHOD; FEMALE; HEART VENTRICLES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYOCARDIUM; OLIGOPEPTIDES; PERCUTANEOUS CORONARY INTERVENTION; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; ST ELEVATION MYOCARDIAL INFARCTION; TIME FACTORS; TREATMENT OUTCOME; TROPONIN I;

EID: 84999036739     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2016.06.025     Document Type: Article

References (26)

1. 1 Geltman, E.M., Ehsani, A.A., Campbell, M.K., Schechtman, K., Roberts, R., Sobel, B.E., The influence of location and extent of myocardial infarction on long- term ventricular dysrhythmia and mortality. Circulation 60 (1979), 805–814.
2. 2 Sobel, B.E., Bresnahan, G.F., Shell, W.E., Yoder, R.D., Estimation of infarct size in man and its relation to prognosis. Circulation 46 (1972), 640–648.
3. 3 Christian, T.F., Schwartz, R.S., Gibbons, R.J., Determinants of infarct size in reperfusion therapy for acute myocardial infarction. Circulation 86 (1992), 81–90.
4. 4 Habib, G.B., Heibig, J., Forman, S.A., Brown, B.G., Roberts, R., Terrin, M.L., Bolli, R., Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I Thrombolysis In Myocardial Infarction (TIMI) trial. The TIMI Investigators. Circulation 83 (1991), 739–746.
5. 5 Hasche, E.T., Fernandes, C., Freedman, S.B., Jeremy, R.W., Relation between ischemia time, infarct size, and left ventricular function in humans. Circulation 92 (1995), 710–719.
6. 6 Reimer, K.A., Jennings, R.B., The “wavefront phenomenon” of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest 40 (1979), 633–644.
7. 7 Herring, M.J., Dai, W., Hale, S.L., Kloner, R.A., Rapid induction of hypothermia by the ThermoSuit System profoundly reduces infarct size and anatomic zone of no reflow following ischemia-reperfusion in rabbit and rat hearts. J Cardiovasc Pharmacol Ther 20 (2015), 193–202.
8. 8 Grande, P., Hansen, B.F., Christiansen, C., Naestoft, J., Estimation of acute myocardial infarct size in man by serum CK-MB measurements. Circulation 65 (1982), 756–764.
9. 9 Hackel, D.B., Reimer, K.A., Ideker, R.E., Mikat, E.M., Hartwell, T.D., Parker, C.B., Braunwald, E.B., Buja, M., Gold, H.K., Jaffe, A.S., Comparison of enzymatic and anatomic estimates of myocardial infarct size in man. Circulation 70 (1984), 824–835.
10. 10 Sandstede, J.J.W., Lipke, C., Beer, M., Harre, K., Pabst, T., Kenn, W., Neubauer, S., Hahn, D., Analysis of first-pass and delayed contrast-enhancement patterns of dysfunctional myocardium on MR imaging. Am J Roentgenol 174 (2000), 1737–1740.
11. 11 Kim, R.J., Fieno, D.S., Parrish, T.B., Harris, K., Chen, E.L., Simonetti, O., Bundy, J., Finn, J.P., Klocke, F.J., Judd, R.M., Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 100 (1999), 1992–2002.
12. 12 Gibbons, R.J., Miller, T.D., Christian, T.F., Infarct size measured by single photon emission computed tomographic imaging with (99m)Tc-sestamibi: a measure of the efficacy of therapy in acute myocardial infarction. Circulation 101 (2000), 101–108.
13. 13 Chakrabarti, A.K., Feeney, K., Abueg, C., Brown, D.A., Czyz, E., Tendera, M., Janosi, A., Giugliano, R.P., Kloner, R.A., Weaver, W.D., Bode, C., Godlewski, J., Merkely, B., Gibson, C.M., Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction. Am Heart J 165 (2013), 509–514.e7.
14. 14 Gibson, C.M., Giugliano, R.P., Kloner, R.A., Bode, C., Tendera, M., Janosi, A., Merkely, B., Godlewski, J., Halaby, R., Korjian, S., Daaboul, Y., Chakrabarti, A.K., Spielman, K., Neal, B.J., Weaver, W.D., EMBRACE STEMI study: a phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention. Eur Heart J 37 (2016), 1296–1303.
15. 15 Eitel, I., Desch, S., Fuernau, G., Hildebrand, L., Gutberlet, M., Schuler, G., Thiele, H., Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J Am Coll Cardiol 55 (2010), 2470–2479.
16. 16 Azen, R., Traxel, N., Using dominance analysis to determine predictor importance in logistic regression. J Educ Behav Stat 34 (2009), 319–347.
17. 17 Johnson, J., Lebreton, J., History and use of relative importance indices in organizational research. Organ Res Meth 7 (2004), 238–257.
18. 18 Budescu, D., Dominance analysis: a new approach to the problem of relative importance of predictors in multiple regression. Psychol Bull 114 (1993), 542–551.
19. 19 Fernandez-Jimenez, R., Silva, J., Martinez-Martinez, S., Lopez-Maderuelo, M.D., Nuno-Ayala, M., Garcia-Ruiz, J.M., Garcia-Alvarez, A., Fernandez-Friera, L., Pizarro, T.G., Garcia-Prieto, J., Sanz-Rosa, D., Lopez-Martin, G., Fernandez-Ortiz, A., Macaya, C., Fuster, V., Redondo, J.M., Ibanez, B., Impact of left ventricular hypertrophy on troponin release during acute myocardial infarction: new insights from a comprehensive translational study. J Am Heart Assoc, 4, 2015, e001218.
20. 20 Stone, G.W., Maehara, A., Witzenbichler, B., Godlewski, J., Parise, H., Dambrink, J.H., Ochala, A., Carlton, T.W., Cristea, E., Wolff, S.D., Brener, S.J., Chowdhary, S., El-Omar, M., Neunteufl, T., Metzger, D.C., Karwoski, T., Dizon, J.M., Mehran, R., Gibson, C.M., Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial. JAMA 307 (2012), 1817–1826.
21. 21 Wu, K.C., Zerhouni, E.A., Judd, R.M., Lugo-Olivieri, C.H., Barouch, L.A., Schulman, S.P., Blumenthal, R.S., Lima, J.A., Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation 97 (1998), 765–772.
22. 22 Sano, M., Minamino, T., Toko, H., Miyauchi, H., Orimo, M., Qin, Y., Akazawa, H., Tateno, K., Kayama, Y., Harada, M., Shimizu, I., Asahara, T., Hamada, H., Tomita, S., Molkentin, J.D., Zou, Y., Komuro, I., p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446 (2007), 444–448.
23. 23 Marchetti, G.V., Merlo, L., Noseda, V., Visioli, O., Myocardial blood flow in experimental cardiac hypertrophy in dogs. Cardiovasc Res 7 (1973), 519–527.
24. 24 Hoffman, J.I., Maximal coronary flow and the concept of coronary vascular reserve. Circulation 70 (1984), 153–159.
25. 25 Strauer, B.E., Myocardial oxygen consumption in chronic heart disease: role of wall stress, hypertrophy and coronary reserve. Am J Cardiol 44 (1979), 730–740.
26. 26 Verma, A., Meris, A., Skali, H., Ghali, J.K., Arnold, J.M., Bourgoun, M., Velazquez, E.J., McMurray, J.J., Kober, L., Pfeffer, M.A., Califf, R.M., Solomon, S.D., Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan in Acute myocardial iNfarcTion) Echocardiographic Study. J Am Coll Cardiol Cardiovasc Imaging 1 (2008), 582–591.