Comparison of therapy persistence for fixed versus free combination antihypertensives: A retrospective cohort study

BMJ Open

Volumn 6, Issue 11, 2016, Pages

  Grimmsmann, Thomas ^a,b   Himmel, Wolfgang ^c  

^a Health Insurance Medical Service (MDK) Mecklenburg Vorpommern   (Germany)

^b UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ADULT; ANTIHYPERTENSIVE THERAPY; COHORT ANALYSIS; COMPARATIVE STUDY; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MONOTHERAPY; PRESCRIPTION; RETROSPECTIVE STUDY; REVIEW; RISK ASSESSMENT; AGED; COMBINATION DRUG THERAPY; DRUG COMBINATION; MEDICATION COMPLIANCE; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADULT; AGED; ANTIHYPERTENSIVE AGENTS; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPERTENSION; LOGISTIC MODELS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 84998880821     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2016-011650     Document Type: Review

References (27)

1. Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;31:1281-357.
2. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001;23:1296-310.
3. Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension 2010;55:399-407.
4. Dezii CM. A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Manag Care 2001;10(2 Suppl):6-10.
5. Jackson K, Brixner D, Oderda G, et al. Compliance and persistence of fixed dose versus free dose combination therapy with valsartan and HCTZ for patients with hypertension. Value Health 2006;9:A363.
6. Wang TD, Chen YH, Huang CH, et al. Bidirectional adherence changes and associated factors in patients switched from free combinations to equivalent single-pill combinations of antihypertensive drugs. Hypertension 2014;63:958-67.
7. James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-20.
8. Grimmsmann T, Himmel W. Persistence of antihypertensive drug use in German primary care: a follow-up study based on pharmacy claims data. Eur J Clin Pharmacol 2014;70: 295-301.
9. Raebel MA, Schmittdiel J, Karter AJ, et al. Standardizing terminology and definitions of medication adherence and persistence in research employing electronic databases. Med Care 2013;51 (Suppl 3):S11-21.
10. Halpern MT, Khan ZM, Schmier JK, et al. Recommendations for evaluating compliance and persistence with hypertension therapy using retrospective data. Hypertension 2006;47:1039-48.
11. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment 2013. 16th edn. Oslo, 2012, http://www.whocc.no/filearchive/publications/1- 2013guidelines.pdf (accessed 28 Jun 2015).
12. Altman D, Machin D, Bryant T, eds. Statistics with confidence: confidence intervals and statistical guidelines. 2nd edn. London: BMJ Books, 2000.
13. Stokes ME, Davis C, Koch G. Categorical data analysis using SAS. 3rd edn. Cary, NC: SAS Institute, 2012.
14. World Health Organization. Adherence to long-term therapies. Geneva: WHO, 2003:3-93. http://apps.who.int/medicinedocs/pdf/ s4883e/s4883e.pdf (accessed 28 Jun 2015).
15. Selmer R, Blix HS, Landmark K, et al. Choice of initial antihypertensive drugs and persistence of drug use - a 4-year follow-up of 78, 453 incident users. Eur J Clin Pharmacol 2012;68:1435-42.
16. Calderón-Larrañaga A, Diaz E, Poblador-Plou B, et al. Non-adherence to antihypertensive medication: the role of mental and physical comorbidity. Int J Cardiol 2016;207:310-16.
17. Dickinson LM, Basu A. Multilevel modeling and practice-based research. Ann Fam Med 2005;3(Suppl 1):S52-60.
18. Kuritzky L. Module 4: enhancing adherence with antihypertensives: the role of fixed-dose combinations and home blood pressure monitoring. J Fam Pract 2012;61(8 Suppl):S23-6, S35; quiz S33.
19. Corrao G, Zambon A, Parodi A, et al. Discontinuation of and changes in drug therapy for hypertension among newly-treated patients: a population-based study in Italy. J Hypertens 2008;26:819-24.
20. Hasford J, Schröder-Bernhardi D, Rottenkolber M, et al. Persistence with antihypertensive treatments: results of a 3-year follow-up cohort study. Eur J Clin Pharmacol 2007;63:1055-61.
21. Jin J, Sklar GE, Min Sen Oh V, et al. Factors affecting therapeutic compliance: a review from the patient's perspective. Ther Clin Risk Manag 2008;4:269-86.
22. Gradman AH, Basile JN, Carter BL, et al. Combination therapy in hypertension. J Am Soc Hypertens 2010;4:90-8.
23. Burnier M. Antihypertensive combination treatment: state of the art. Curr Hypertens Rep 2015;17:51.
24. Marshall IJ, Wolfe CD, McKevitt C. Lay perspectives on hypertension and drug adherence: systematic review of qualitative research. BMJ 2012;345:e3953.
25. Angeli F, Reboldi G, Mazzotta G, et al. Fixed-dose combination therapy in hypertension: cons. High Blood Press Cardiovasc Prev 2012;19:51-4.
26. Nunes V, Neilson J, O'Flynn N, et al. Clinical guidelines and evidence review for medicines adherence: involving patients in decisions about prescribed medicines and supporting adherence. London: National Collaborating Centre for Primary Care and Royal College of General Practitioners, 2009.
27. McManus RJ, Mant J, Haque M, et al. Effect of self-monitoring and medication self-titration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease: the TASMIN-SR randomized clinical trial. JAMA 2014;312:799-808.