Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease

Neuropathology and Applied Neurobiology

Volumn 43, Issue 5, 2017, Pages 409-418

  Ince, P G ^a   Minett, T ^b,c   Forster, G ^a   Brayne, C ^b   Wharton, S B ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

dementia; epidemiological neuropathology; lacunes; microinfarct; mobility; small vessel disease; vascular risk factors; white matter lesions

Indexed keywords

ADULT; AGED; AGING; ANGINA PECTORIS; ARTERIOSCLEROSIS; ARTICLE; BRAIN INFARCTION; BRAIN REGION; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; CLINICAL OUTCOME; DEMENTIA; DIABETES MELLITUS; FALLING; FEMALE; HEART INFARCTION; HUMAN; IMMOBILITY; MAJOR CLINICAL STUDY; MALE; MICROINFARCTION; NEUROPATHOLOGY; ORGAN DONOR; PREVALENCE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SUBCORTEX; VERY ELDERLY; WHITE MATTER LESION; AUTOPSY; BRAIN; COHORT ANALYSIS; PATHOLOGY; WALKING DIFFICULTY;

AGED; AGED, 80 AND OVER; AUTOPSY; BRAIN; BRAIN INFARCTION; CEREBRAL SMALL VESSEL DISEASES; COHORT STUDIES; DEMENTIA; FEMALE; HUMANS; MALE; MOBILITY LIMITATION; PREVALENCE;

EID: 84998865506     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/nan.12363     Document Type: Article

References (25)

1. Gorelick P, Scuteri A, Black S, Decarli C, Greenberg S, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011; 42: 2672–713
2. Esiri M, Wilcock G, Morris J. Neuropathological assessment of the lesions of significance in vascular dementia. J Neurol Neurosurg Psychiatry 1997; 63: 749–53
3. Smith EE, Schneider JA, Wardlaw JM, Greenberg SM. Cerebral microinfarcts: the invisible lesions. Lancet Neurol 2012; 3: 272–82
4. Auriel E, Edlow B, Reijmer Y, Fotiadis P, Ramirez-Martinez S, Ni J, Reed AK, Vashkevich A, Schwab K, Rosand J, Viswanathan A, Wu O, Gurol ME, Greenberg SM. Microinfarct disruption of white matter structure: A longitudinal diffusion tensor analysis. Neurology 2014; 83: 182–8
5. Lee K, Chambers R, Diamond C, Park C, Thompson NL Jr, Schnapf D, Pripstein S. Evaluation of cerebral infarction by Computed Tomography with special emphasis on microinfarction. Neuroradiology 1978; 16: 156–8
6. Raman M, Preboske G, Przybelski S, Gunter J, Senjem M, Vemuri P, Murphy MC, Murray ME, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Dickson DW, Jack CR Jr, Kantarci K. Antemortem MRI findings associated with microinfarcts at autopsy. Neurology 2014; 82: 1951–8
7. Zheng L, Vinters H, Mack W, Zarow C, Ellis W, Chui HC. Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes. Stroke 2013; 44: 2835–41
8. Gold G, Giannakopoulos P, Herrmann F, Bouras C, Kovari E. Identification of Alzheimer and vascular lesion thresholds for mixed dementia. Brain 2007; 130: 2830–6
9. Launer L, Hughes T, White L. Microinfarcts, brain atrophy, and cognitive function: the Honolulu Asia Aging Study Autopsy Study. Ann Neurol 2011; 70: 774–80
10. White L, Petrovitch H, Hardman J, Nelson J, Davis D, Ross GW, Masaki K, Launer L, Markesbery WR. Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci 2002; 977: 9–23
11. White L, Small B, Petrovitch H, Ross G, Masaki K, Abbott RD, Hardman J, Davis D, Nelson J, Markesbery WR. Recent clinical-pathologic research on the causes of dementia in late life: update from the Honolulu-Asia Aging Study. J Geriatr Psychiatry Neurol 2005; 18: 224–7
12. Ballard C, McKeith I, O'Brien J, Kalaria R, Jaros E, Ince P, Perry R. Neuropathological substrates of dementia and depression in vascular dementia, with a particular focus on cases with small infarct volumes. Dement Geriatr Cogn Disord 2000; 11: 59–65
13. Matthews F, Brayne C, Lowe J, McKeith I, Wharton S, Ince P. Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council cognitive Function and Ageing Study. PLoS Med 2009; 6: e1000180
14. Neuropathology Group of MRC Cognitive Function and Ageing Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001; 357: 169–75
15. Fernando M, Ince P. Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci 2004; 226: 13–17
16. Wharton S, Simpson J, Brayne C, Ince P. Age-associated White Matter Lesions: the MRC Cognitive Function and Ageing Study. Brain Pathol 2015; 25: 35–43
17. Mirra S, Heyman A, McKeel D, Sumi S, Crain B, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991; 41: 479–86.
18. Arvanitakis Z, Leurgans S, Barnes L, Bennet D, Schneider J. Microinfarct pathology, dementia and cognitive systems. Stroke 2011; 42: 722–7
19. Gallacher J, Bayer A, Lowe G, Fish M, Pickering J, Pedro S, Dunstan F, White J, Yarnell J, Ben-Shlomo Y. Is sticky blood bad for the brain?: hemostatic and inflammatory systems and dementia in the Caerphilly Prospective Study. Arterioscler Thromb Vasc Biol 2010; 30: 599–604
20. Deramecourt V, Slade J, Oakley A, Perry R, Ince P, Maurage CN, Kalaria RN. Staging and natural history of cerebrovascular pathology in dementia. Neurology 2011; 78: 1043–50
21. Pantoni L, Sarti C, Alafuzoff I, Jellinger K, Munoz DG, Ogata J, Palumbo V. Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological services. Stroke 2006; 37: 1005–9
22. Vinters H, Ellis W, Zarow C, Zaias B, Jagust W, Mack WJ, Chui HC. Neuropathologic substrates of ischemic vascular dementia. J Neuropathol Exp Neurol 2000; 59: 931–45
23. Westover M, Bianchi M, Yang C, Schneider J, Greenberg S. Estimating cerebral microinfarct burden from autopsy samples. Neurology 2013; 80: 1365–9.
24. Poirier J, Derouesne C. Cerebral lacunae. A proposed new classification. Clin Neuropathol 1984; 3: 266
25. McAleese K, Firbank M, Hunter D, Sun L, Hall R, Neal J, Mann DM, Esiri M, Jellinger KA, O'Brien JT, Attems J. Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter. Neuropathol Appl Neurobiol 2013; 39: 485–97