The influence and changes in the dosages of concomitantly used psychotropic drugs associated with the discontinuation of donepezil in severe Alzheimer's disease with behavioral and psychological symptoms on dementia: A preliminary open-label trial

Therapeutic Advances in Psychopharmacology

Volumn 4, Issue 1, 2014, Pages 37-42

  Suzuki, Hidenobu ^a   Inoue, Yuichi ^b   Mikami, Katsunaka ^c   Gen, Keishi ^d  

^a Suzuki Clinic   (Japan)

^b Shakomae Kokorono Clinic   (Japan)

^c TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Seimo Hospital   (Japan)

Author keywords

Alzheimer's disease; behavioral and psychological symptoms on dementia; donepezil; psychotropic drugs

Indexed keywords

EID: 84997906982     PISSN: 20451253     EISSN: 20451261     Source Type: Journal    
DOI: 10.1177/2045125313508130     Document Type: Article

References (19)

1. Aisen P. Johanssen D. Marin D. (1993) Trazodone for behavioral disturbance in dementia. Am J Geriatr Psychiatry 1: 349–350.
2. Clerici F. Vanacore N. Elia A. Spila-Alegiani S Pomati S. Da Cas R. (2011) Memantine Lombardy Study Group. Memantine effects on behaviour in moderately severe to severe Alzheimer's disease: a post-marketing surveillance study. Neurol Sci 33: 23–31.
3. Cummings J. Mega M. Gray K. Rosenberg-Thompson S. Carusi D. Gornbein J. (1994). The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44: 2308–2314.
4. Cummings J. Schneider E. Tariot P. Graham S. (2006) Behavioral effects of memantine in Alzheimer's disease patients receiving donepezil treatment. Neurology 67: 57–63.
5. Finkel S. Costa E. Silva J. Cohen G. Miller S. Sartorius N. (1996) Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 8: 497–500.
6. Folstein M. Folstein S. McHugh P. (1975) ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-98.
7. Inagaki A. Inada T. (2006) Dose equivalence of psychotropic drugs. Part XVIII: dose equivalence of psychotropic drugs (in Japanese). Jpn J Psychopharmacol 9: 1443–1447.
8. Inagaki A. Inada T. (2012) Dose equivalence of psychotropic drugs. Part XXIII: dose equivalence of novel antipsychotics (in Japanese). Jpn J Psychopharmacol 15: 397–404.
9. Inoue Y. Suzuki H. Otomo M. Gen K. (2011) Study of the efficacy and safety of risperidone long-acting injection in elderly schizophrenia patients (in Japanese). Jpn J New Clin 60: 109–116.
10. Kimura T. Hayashida H. Miyauchi D. Takamatsu J. (2010) Drug-resistant dementia with Lewy bodies: case report of 3 patients showing good response to aripiprazole treatment (in Japanese). Clin Psychiatry 52: 575–582.
11. Kimura T. Takamatsu J. (2013a) Pilot study of pharmacological treatment for frontotemporal dementia: Risk of donepezil treatment for behavioral and psychological symptoms. J Geriatr Gerontol Int 13: 506–507.
12. Kimura T. Takamatsu J. (2013b) Two cases of Alzheimer's disease showing deterioration of behavioral and psychological symptoms of dementia induced by switching from rivastigmine to donepezil. Neuropsychiatr Dis Treat 9: 49–53.
13. Kudo T. (2012) The effect of mematine on BPSD (in Japanese). Jpn J Psychopharmacol 15: 53–58.
14. Lawlor B. (1990) Serotonin and Alzheimer's disease. Psychiat Ann 20: 567–570.
15. Lawlor B. Radcliffe J. Molchan S. Martinez R. Hill J. Sunderland T. (1994) A pilot placebo-controlled study of trazodone and buspirone in Alzhermer's disease. Int J Geriatr Psychiatry 9: 55–59.
16. McKhann G. Drachman D. Folstein M. Katzman R. Price D. Stadlan E. (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939–944.
17. Pinner E. Rich C. (1988) Effects of trazodone on aggressive behavior in seven patients with organic mental disorders. Am J Psychiatry 145: 1295–1296.
18. Sultzer D. Gray K. Gunay I. Berisford M. Mahler M. (1997) A double-blind comparison of trazodone and haloperidol for treatment of agitation in patients with dementia. Am J Geriatr Psychiatry 5: 60–69.
19. Suzuki H. Inoue Y. Nishiyama A. Mikami K. Gen K. (2013) Clinical efficacy and changes in the dosages of concomitantly used psychotropic drugs in memantine therapy in Alzheimer's disease with behavioral and psychological symptoms on dementia. Ther Adv Psychopharmacol 3: 123–128.