Anticoagulant therapy for symptomatic calf deep vein thrombosis (CACTUS): a randomised, double-blind, placebo-controlled trial

The Lancet Haematology

Volumn 3, Issue 12, 2016, Pages e556-e562

  Righini, Marc ^a   Galanaud, Jean Philippe ^b   Guenneguez, Hervé ^c   Brisot, Dominique ^b   Diard, Antoine ^d   Faisse, Pascale ^e   Barrellier, Marie Thérèse ^f   Hamel Desnos, Claudine ^f   Jurus, Christine ^g   Pichot, Olivier ^h   Martin, Myriam ⁱ   Mazzolai, Lucia ^j   Choquenet, Clarisse ^k   Accassat, Sandrine ^l   Robert Ebadi, Helia ^a   Carrier, Marc ^m   Le Gal, Grégoire ^m   Mermilllod, Bernadette ^a   Laroche, Jean Pierre ^b   Bounameaux, Henri ^a,b   Perrier, Arnaud ^a   Kahn, Susan R ⁿ   Quere, Isabelle ^b   more..

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

^c Clinique Megival   (France)

^d Vascular Medicine Unit   (France)

^e Vascular Medicine   (France)

^f CAEN UNIVERSITY HOSPITAL   (France)

^g Department of Nephrology   (France)

^h GRENOBLE UNIVERSITY HOSPITAL   (France)

ⁱ Vascular Medicine   (France)

^j LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^k Vascular Medicine   (France)

^l UNIVERSITÉ JEAN MONNET   (France)

^m OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

ⁿ MCGILL UNIVERSITY   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

NADROPARIN; PLACEBO; ANTICOAGULANT AGENT;

ADULT; ANTICOAGULATION; ARTICLE; BLEEDING; COMMUNITY CARE; COMPRESSION STOCKING; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG WITHDRAWAL; ECHOGRAPHY; EVALUATION AND FOLLOW UP; FEMALE; GASTROCNEMIUS MUSCLE; HUMAN; KIDNEY FUNCTION TEST; LUNG ANGIOGRAPHY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RASH; RESEARCH; THROMBOCYTE COUNT; THROMBOCYTOPENIA; VENOUS THROMBOEMBOLISM; YOUNG ADULT; AGED; CANADA; CHEMICALLY INDUCED; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DOUBLE BLIND PROCEDURE; EARLY TERMINATION OF CLINICAL TRIAL; FRANCE; LEG; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL; PROCEDURES; RISK ASSESSMENT; RISK FACTOR; SECONDARY PREVENTION; STANDARDS; STATISTICS AND NUMERICAL DATA; SWITZERLAND; TREATMENT OUTCOME; VASCULARIZATION; VEIN; VEIN THROMBOSIS;

ADULT; AGED; ANTICOAGULANTS; CANADA; DOUBLE-BLIND METHOD; EARLY TERMINATION OF CLINICAL TRIALS; EXANTHEMA; FEMALE; FRANCE; HEMORRHAGE; HUMANS; LEG; MALE; MIDDLE AGED; NADROPARIN; PULMONARY EMBOLISM; RISK ASSESSMENT; RISK FACTORS; SECONDARY PREVENTION; STOCKINGS, COMPRESSION; SWITZERLAND; THROMBOCYTOPENIA; TREATMENT OUTCOME; ULTRASONOGRAPHY; VEINS; VENOUS THROMBOSIS;

EID: 84997702013     PISSN: None     EISSN: 23523026     Source Type: Journal    
DOI: 10.1016/S2352-3026(16)30131-4     Document Type: Article

References (22)

1. 1 Righini, M, Is it worth diagnosing and treating distal deep vein thrombosis? No. J Thromb Haemost 5:suppl 1 (2007), 55–59.
2. 2 Righini, M, Paris, S, Le Gal, G, Laroche, JP, Perrier, A, Bounameaux, H, Clinical relevance of distal deep vein thrombosis. Review of literature data. Thromb Haemost 95 (2006), 56–64.
3. 3 Galanaud, JP, Sevestre-Pietri, MA, Bosson, JL, et al. Comparative study on risk factors and early outcome of symptomatic distal versus proximal deep vein thrombosis: results from the OPTIMEV study. Thromb Haemost 102 (2009), 493–500.
4. 4 Kearon, C, Akl, EA, Comerota, AJ, et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141 (2012), e419S–e494S.
5. 5 Palareti, G, How I treat isolated distal deep vein thrombosis (IDDVT). Blood 123 (2014), 1802–1809.
6. 6 Schellong, SM, Distal DVT: worth diagnosing? Yes. J Thromb Haemost 5:suppl 1 (2007), 51–54.
7. 7 Almosni, J, Meusy, A, Frances, P, Pontal, D, Quere, I, Galanaud, JP, Practice variation in the management of distal deep vein thrombosis in primary vs. secondary cares: a clinical practice survey. Thromb Res 136 (2015), 526–530.
8. 8 Masuda, EM, Kistner, RL, Musikasinthorn, C, Liquido, F, Geling, O, He, Q, The controversy of managing calf vein thrombosis. J Vasc Surg 55 (2012), 550–561.
9. 9 Johnson, SA, Stevens, SM, Woller, SC, et al. Risk of deep vein thrombosis following a single negative whole-leg compression ultrasound: a systematic review and meta-analysis. Jama 303 (2010), 438–445.
10. 10 Cogo, A, Lensing, AW, Koopman, MM, et al. Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study. BMJ 316 (1998), 17–20.
11. 11 Wells, PS, Hirsh, J, Anderson, DR, et al. A simple clinical model for the diagnosis of deep-vein thrombosis combined with impedance plethysmography: potential for an improvement in the diagnostic process. J Intern Med 243 (1998), 15–23.
12. 12 Bernardi, E, Camporese, G, Buller, HR, et al. Serial 2-point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein thrombosis: a randomized controlled trial. Jama 300 (2008), 1653–1659.
13. 13 Gibson, NS, Schellong, SM, Kheir, DY, et al. Safety and sensitivity of two ultrasound strategies in patients with clinically suspected deep venous thrombosis: a prospective management study. J Thromb Haemost 7 (2009), 2035–2041.
14. 14 Galanaud, JP, Sevestre, MA, Genty, C, et al. Incidence and predictors of venous thromboembolism recurrence after a first isolated distal deep vein thrombosis. J Thromb Haemost 12 (2014), 436–443.
15. 15 Schulman, S, Rhedin, AS, Lindmarker, P, et al. A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism. Duration of Anticoagulation Trial Study Group. N Engl J Med 332 (1995), 1661–1665.
16. 16 Pinede, L, Ninet, J, Duhaut, P, et al. Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Circulation 103 (2001), 2453–2460.
17. 17 Schulman, S, Kearon, C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost 3 (2005), 692–694.
18. 18 Lagerstedt, CI, Olsson, CG, Fagher, BO, Oqvist, BW, Albrechtsson, U, Need for long-term anticoagulant treatment in symptomatic calf-vein thrombosis. Lancet 2 (1985), 515–518.
19. 19 Schwarz, T, Buschmann, L, Beyer, J, Halbritter, K, Rastan, A, Schellong, S, Therapy of isolated calf muscle vein thrombosis: a randomized, controlled study. J Vasc Surg 52 (2010), 1246–1250.
20. 20 Birdwell, BG, Raskob, GE, Whitsett, TL, et al. The clinical validity of normal compression ultrasonography in outpatients suspected of having deep venous thrombosis. Ann Intern Med 128 (1998), 1–7.
21. 21 Kraaijenhagen, RA, Piovella, F, Bernardi, E, et al. Simplification of the diagnostic management of suspected deep vein thrombosis. Arch Intern Med 162 (2002), 907–911.
22. 22 Decousus, H, Prandoni, P, Mismetti, P, et al. Fondaparinux for the treatment of superficial-vein thrombosis in the legs. N Engl J Med 363 (2010), 1222–1232.