Hypoxanthine: A new paradigm to interpret the origin of transfusion toxicity

Blood Transfusion

Volumn 14, Issue 6, 2016, Pages 555-556

  Casali, Emanuela ^a   Berni, Pamela ^b   Spisni, Alberto ^a   Baricchi, Roberto ^b   Pertinhez, Thelma A ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b S MARIA NUOVA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE; REACTIVE OXYGEN METABOLITE;

BLOOD TRANSFUSION; ERYTHROCYTE PRESERVATION; HUMAN; LETTER; LEUKOCYTE ACTIVATION; METABOLOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; SHELF LIFE; TOXICITY; TRANSFUSION TOXICITY;

EID: 84997418940     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: 10.2450/2015.0177-15     Document Type: Letter

References (6)

1. Neal MD, Raval JS, Triulzi DJ, Simmons RL. Innate immune activation after transfusion of stored red blood cells. Transf Med Rev 2013; 27: 113-8.
2. Pertinhez TA, Casali E, Lindner L, et al. Biochemical assessment of red blood cells during storage by 1H nuclear magnetic resonance spectroscopy. Identification of a biomarker of their level of protection against oxidative stress. Blood Transfus 2014; 12: 548-56.
3. Cantu-Medellin N, Kelley EE. Xanthine oxidoreductasecatalyzed reactive species generation: a process in critical need of reevaluation. Redox Biol 2013; 1: 353-8.
4. Battelli MG, Bolognesi A, Polito L. Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi-tasking enzyme. Biochim Biopys Acta 2014; 1842: 1502-17.
5. Beyer G, Melzig MF. Effects of selected flavonoids and caffeic acid derivatives on hypoxanthine-xanthine oxidaseinduced toxicity in cultivated human cells. Planta Med 2003; 69: 1125-9.
6. Sparrow RL: Time to revisit red blood cell additive solutions and storage conditions: a role for "omics" analyses. Blood Transfus 2012; 10 (Suppl 2): s7-11.