Stroke severity is a crucial predictor of outcome: An international prospective validation study

Journal of the American Heart Association

Volumn 5, Issue 1, 2016, Pages 1-7

  Rost, Natalia S ^a   Bottle, Alex ^b   Lee, Jin Moo ^c,r   Randall, Marc ^d,p   Middleton, Steven ^e   Shaw, Louise ^f   Thijs, Vincent ^g,h,k   Rinkel, Gabriel J E ⁱ   Hemmen, Thomas M ^j   Eleopra, Roberto ^l   van Oostenbrugge, R J ^m   Fenwick, Caroline ⁿ   Pelly, Michael ⁿ   Vaux, Emma ^o   van Wyk, André ^o   Spencer, Mary ^q   Peggy, Gudridur ^r   Matzkiw, H ^r   Newman, Jillian ^r  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e Dr Foster Intelligence   (United Kingdom)

^f ROYAL UNITED HOSPITALS BATH NHS FOUNDATION TRUST   (United Kingdom)

^g UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^h UNIVERSITY OF MELBOURNE   (Australia)

ⁱ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^j UNIVERSITY OF CALIFORNIA SAN DIEGO HEALTH SYSTEM   (United States)

^k University of Leuven   (Italy)

^l SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^m MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁿ CHELSEA AND WESTMINSTER HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^o ROYAL BERKSHIRE NHS FOUNDATION TRUST   (United Kingdom)

^p Sheffield Teaching Hospitals NHS Foundation Trust   (United States)

^q BARNES JEWISH HOSPITAL   (United States)

^r HUNTSVILLE HOSPITAL   (United States)

more..

Author keywords

Mortality; Statistics; Stroke; Survival

Indexed keywords

ADULT; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEALTH CARE SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; RATING SCALE; SCORING SYSTEM; TREATMENT OUTCOME; VALIDATION PROCESS; CLINICAL TRIAL; DECISION SUPPORT SYSTEM; EUROPE; HOSPITAL MORTALITY; MORTALITY; MULTICENTER STUDY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROGNOSIS; REPRODUCIBILITY; RISK ASSESSMENT; RISK FACTOR; SEVERITY OF ILLNESS INDEX; STROKE; TIME FACTOR; UNITED STATES; VALIDATION STUDY;

COMORBIDITY; DECISION SUPPORT TECHNIQUES; EUROPE; HOSPITAL MORTALITY; HUMANS; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STROKE; TIME FACTORS; UNITED STATES;

EID: 84997254307     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.115.002433     Document Type: Article

References (32)

1. Feigin VLLC, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8:355-369.
2. Executive summary: heart disease and stroke statistics-2010 update: a report from the American Heart Association; on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2010;121:948-954.
3. Gropen TI, Gagliano PJ, Blake CA, Sacco RL, Kwiatkowski T, Richmond NJ, Leifer D, Libman R, Azhar S, Daley MB; NYSDOH Stroke Center Designation Project Workgroup. Quality improvement in acute stroke: the New York State Stroke Center Designation Project. Neurology. 2006;67:88-93.
4. Fonarow GC, Reeves MJ, Smith EE, Saver JL, Zhao X, Olson DW, Hernandez AF, Peterson ED, Schwamm LH; GWTG-Stroke Steering Committee and Investigators. Characteristics, performance measures, and in-hospital outcomes of the first one million stroke and transient ischemic attack admissions in get with the guidelines-stroke. Circ Cardiovasc Qual Outcomes. 2010;3:291-302.
5. Reeves MJ, Grau-Sepulveda MV, Fonarow GC, Olson DM, Smith EE, Schwamm LH. Are quality improvements in the get with the guidelines-stroke program related to better care or better data documentation? Circ Cardiovasc Qual Outcomes. 2011;4:503-511.
6. Rost NS, Smith EE, Pervez MA, Mello P, Dreyer P, Schwamm LH. Predictors of increased intravenous tissue plasminogen activator use among hospitals participating in the Massachusetts Primary Stroke Service Program. Circ Cardiovasc Qual Outcomes. 2012;5:314-320.
7. Bottle A, Middleton S, Kalkman CJ, Livingston EH, Aylin P. Global comparators project: international comparison of hospital outcomes using administrative data. Health Serv Res. 2013;48:2081-2100.
8. Van Hooff RJ, Nieboer K, De Smedt A, Moens M, De Deyn PP, De Keyser J, Brouns R. Validation assessment of risk tools to predict outcome after thrombolytic therapy for acute ischemic stroke. Clin Neurol Neurosurg. 2014;125C:189-193.
9. Sarraj A, Albright K, Barreto AD, Boehme AK, Sitton CW, Choi J, Lutzker SL, Sun CH, Bibars W, Nguyen CB, Mir O, Vahidy F, Wu TC, Lopez GA, Gonzales NR, Edgell R, Martin-Schild S, Hallevi H, Chen PR, Dannenbaum M, Saver JL, Liebeskind DS, Nogueira RG, Gupta R, Grotta JC, Savitz SI. Optimizing prediction scores for poor outcome after intra-arterial therapy in anterior circulation acute ischemic stroke. Stroke. 2013;44:3324-3330.
10. Shuaib A, Schwab S, Rutledge JN, Starkman S, Liebeskind DS, Bernardini GL, Boulos A, Abou-Chebl A, Huang DY, Vanhooren G, Cruz-Flores S, Klucznik RP, Saver JL; SENTIS trial investigators. Importance of proper patient selection and endpoint selection in evaluation of new therapies in acute stroke: further analysis of the SENTIS trial. J Neurointerv Surg. 2013;5(suppl 1):i21-i24.
11. Bruno A, Shah N, Lin C, Close B, Hess DC, Davis K, Baute V, Switzer JA, Waller JL, Nichols FT. Improving modified Rankin Scale assessment with a simplified questionnaire. Stroke. 2010;41:1048-1050.
12. Bruno A, Akinwuntan AE, Lin C, Close B, Davis K, Baute V, Aryal T, Brooks D, Hess DC, Switzer JA, Nichols FT. Simplified modified Rankin Scale questionnaire: reproducibility over the telephone and validation with quality of life. Stroke. 2011;42:2276-2279.
13. König IR, Ziegler A, Bluhmki E, Hacke W, Bath PMW, Sacco RL, Diener HC, Weimar C; Virtual International Stroke Trials Archive (VISTA) Investigators. Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials. Stroke. 2008;39:1821-1826.
14. Ovbiagele B, Saver JL. Day-90 acute ischemic stroke outcomes can be derived from early functional activity level. Cerebrovasc Dis. 2010;29:50-56.
15. Bray BD, Campbell J, Cloud GC, Hoffman A, James M, Tyrrell PJ, Wolfe CD, Rudd AG; Intercollegiate Stroke Working Party Group. Derivation and external validation of a case mix model for the standardized reporting of 30-day stroke mortality rates. Stroke. 2014;45:3374-3380.
16. Ali M, Atula S, Bath PM, Grotta J, Hacke W, Lyden P, Marler JR, Sacco RL, Lees KR; VISTA Investigators. Stroke outcome in clinical trial patients deriving from different countries. Stroke. 2009;40:35-40.
17. Ovbiagele B, Lyden PD, Saver JL. Disability status at 1 month is a reliable proxy for final ischemic stroke outcome. Neurology. 2010;75:688-692.
18. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1588.
19. Saver JL, Altman H. Relationship between neurologic deficit severity and final functional outcome shifts and strengthens during first hours after onset. Stroke. 2012;43:1537-1541.
20. Heinze GSM. Comparing the importance of prognostic factors in Cox and logistic regression using SAS. Comput Methods Programs Biomed. 2003;71:155-163.
21. Cohen J. Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. Psychol Bull. 1968;70:213-220.
22. Hosmer DW, Lemeshow S. Applied Logistic Regression. New York, NY: John Wiley & Sons; 1989.
23. Rankin J. Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J. 1957;2:200-215.
24. van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke. 1988;19:604-607.
25. Quinn TJ, Dawson J, Walters MR, Lees KR. Reliability of the modified Rankin Scale: a systematic review. Stroke. 2009;40:3393-3395.
26. Janssen PM, Visser NA, Dorhout Mees SM, Klijn CJM, Algra A, Rinkel GJE. Comparison of telephone and face-to-face assessment of the modified Rankin Scale. Cerebrovasc Dis. 2010;29:137-139.
27. Wilson JT, Hareendran A, Hendry A, Potter J, Bone I, Muir KW. Reliability of the modified Rankin Scale across multiple raters: benefits of a structured interview. Stroke. 2005;36:777-781.
28. Banks JL, Marotta CA. Outcomes validity and reliability of the modified Rankin Scale: implications for stroke clinical trials: a literature review and synthesis. Stroke. 2007;38:1091-1096.
29. Saver JL, Yafeh B. Confirmation of tPA treatment effect by baseline severityadjusted end point reanalysis of the NINDS-tPA stroke trials. Stroke. 2007;38:414-416.
30. Garofolo KM, Yeatts SD, Ramakrishnan V, Jauch EC, Johnston KC, Durkalski VL. The effect of covariate adjustment for baseline severity in acute stroke clinical trials with responder analysis outcomes. Trials. 2013;14:98.
31. Fonarow GC, Pan W, Saver JL, Smith EE, Reeves MJ, Broderick JP, Kleindorfer DO, Sacco RL, Olson DM, Hernandez AF, Peterson ED, Schwamm LH. Comparison of 30-day mortality models for profiling hospital performance in acute ischemic stroke with vs without adjustment for stroke severity. JAMA. 2012;308:257-264.
32. Fonarow GC, Alberts MJ, Broderick JP, Jauch EC, Kleindorfer DO, Saver JL, Solis P, Suter R, Schwamm LH. Stroke outcomes measures must be appropriately risk adjusted to ensure quality care of patients: a presidential advisory from the American Heart Association/American Stroke Association. Stroke. 2014;45:1589-1601.